Ontology: Biological Process (GO:0031167)

Definition: The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule.

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term rRNA methylation (48 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	rRNA methylation	46
High-throughput	none	none
Computational (download data)	rRNA methylation	2

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term rRNA methylation or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

rRNA methylation      48 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
DIM1/YPL266W	IEA: Inferred from Electronic Annotation with EBI:IPR001737, EBI:IPR020596, EBI:IPR020598 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	GOC
MRM2/YGL136C	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2006-05-12	manually curated	Pintard L, et al.  (2002) MRM2 encodes a novel yeast mitochondrial 21S rRNA methyltransferase. EMBO J 21(5):1139-47	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2006-05-12	manually curated	Bonnerot C, et al.  (2003) Functional redundancy of Spb1p and a snR52-dependent mechanism for the 2'-O-ribose methylation of a conserved rRNA position in yeast. Mol Cell 12(5):1309-15	SGD
MTF1/YMR228W	IEA: Inferred from Electronic Annotation with EBI:IPR001737 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	GOC
NOP1/YDL014W	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2012-08-06	manually curated	Galardi S, et al.  (2002) Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro. Mol Cell Biol 22(19):6663-8	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2008-08-13	manually curated	Tollervey D, et al.  (1993) Temperature-sensitive mutations demonstrate roles for yeast fibrillarin in pre-rRNA processing, pre-rRNA methylation, and ribosome assembly. Cell 72(3):443-57	SGD
RRP8/YDR083W	IMP: Inferred from Mutant Phenotype Assigned on 2013-02-20	manually curated	Peifer C, et al.  (2013) Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA. Nucleic Acids Res 41(2):1151-63	SGD
SNR128/snR128	ISS: Inferred from Sequence or structural Similarity Assigned on 2006-08-23	manually curated	Kiss-Laszlo Z, et al.  (1996) Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs. Cell 85(7):1077-88	SGD
SNR13/snR13	IMP: Inferred from Mutant Phenotype, ISM: Inferred from Sequence Model Assigned on 2008-04-16	manually curated	Lowe TM and Eddy SR  (1999) A computational screen for methylation guide snoRNAs in yeast. Science 283(5405):1168-71	SGD
SNR18/snR18	ISS: Inferred from Sequence or structural Similarity Assigned on 2006-08-23	manually curated	Kiss-Laszlo Z, et al.  (1996) Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs. Cell 85(7):1077-88	SGD
SNR24/snR24	IMP: Inferred from Mutant Phenotype, ISS: Inferred from Sequence or structural Similarity Assigned on 2006-08-23	manually curated	Kiss-Laszlo Z, et al.  (1996) Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs. Cell 85(7):1077-88	SGD
SNR38/snR38	ISS: Inferred from Sequence or structural Similarity Assigned on 2006-08-23	manually curated	Kiss-Laszlo Z, et al.  (1996) Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs. Cell 85(7):1077-88	SGD
SNR39/snR39	ISS: Inferred from Sequence or structural Similarity Assigned on 2006-08-23	manually curated	Kiss-Laszlo Z, et al.  (1996) Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs. Cell 85(7):1077-88	SGD
SNR39B/snR39B	IMP: Inferred from Mutant Phenotype, ISM: Inferred from Sequence Model Assigned on 2008-04-16	manually curated	Lowe TM and Eddy SR  (1999) A computational screen for methylation guide snoRNAs in yeast. Science 283(5405):1168-71	SGD
SNR40/snR40	IMP: Inferred from Mutant Phenotype, ISM: Inferred from Sequence Model Assigned on 2008-04-16	manually curated	Lowe TM and Eddy SR  (1999) A computational screen for methylation guide snoRNAs in yeast. Science 283(5405):1168-71	SGD
	ISS: Inferred from Sequence or structural Similarity Assigned on 2006-08-23	manually curated	Kiss-Laszlo Z, et al.  (1996) Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs. Cell 85(7):1077-88	SGD
SNR41/snR41	IMP: Inferred from Mutant Phenotype, ISM: Inferred from Sequence Model Assigned on 2008-04-16	manually curated	Lowe TM and Eddy SR  (1999) A computational screen for methylation guide snoRNAs in yeast. Science 283(5405):1168-71	SGD
	ISS: Inferred from Sequence or structural Similarity Assigned on 2006-08-23	manually curated	Kiss-Laszlo Z, et al.  (1996) Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs. Cell 85(7):1077-88	SGD
SNR47/snR47	IMP: Inferred from Mutant Phenotype, ISM: Inferred from Sequence Model Assigned on 2008-04-16	manually curated	Lowe TM and Eddy SR  (1999) A computational screen for methylation guide snoRNAs in yeast. Science 283(5405):1168-71	SGD
SNR48/snR48	IMP: Inferred from Mutant Phenotype, ISM: Inferred from Sequence Model Assigned on 2008-04-16	manually curated	Lowe TM and Eddy SR  (1999) A computational screen for methylation guide snoRNAs in yeast. Science 283(5405):1168-71	SGD
SNR50/snR50	IMP: Inferred from Mutant Phenotype, ISM: Inferred from Sequence Model Assigned on 2008-04-16	manually curated	Lowe TM and Eddy SR  (1999) A computational screen for methylation guide snoRNAs in yeast. Science 283(5405):1168-71	SGD
SNR51/snR51	IMP: Inferred from Mutant Phenotype, ISM: Inferred from Sequence Model Assigned on 2008-04-16	manually curated	Lowe TM and Eddy SR  (1999) A computational screen for methylation guide snoRNAs in yeast. Science 283(5405):1168-71	SGD
SNR52/snR52	IMP: Inferred from Mutant Phenotype, ISM: Inferred from Sequence Model Assigned on 2008-04-16	manually curated	Lowe TM and Eddy SR  (1999) A computational screen for methylation guide snoRNAs in yeast. Science 283(5405):1168-71	SGD
	IGI: Inferred from Genetic Interaction with SGD:SPB1, IMP: Inferred from Mutant Phenotype Assigned on 2006-05-16	manually curated	Lapeyre B and Purushothaman SK  (2004) Spb1p-directed formation of Gm2922 in the ribosome catalytic center occurs at a late processing stage. Mol Cell 16(4):663-9	SGD
SNR53/snR53	IMP: Inferred from Mutant Phenotype, ISM: Inferred from Sequence Model Assigned on 2008-04-16	manually curated	Lowe TM and Eddy SR  (1999) A computational screen for methylation guide snoRNAs in yeast. Science 283(5405):1168-71	SGD
SNR54/snR54	IMP: Inferred from Mutant Phenotype, ISM: Inferred from Sequence Model Assigned on 2008-04-16	manually curated	Lowe TM and Eddy SR  (1999) A computational screen for methylation guide snoRNAs in yeast. Science 283(5405):1168-71	SGD
SNR55/snR55	ISM: Inferred from Sequence Model Assigned on 2008-04-16	manually curated	Lowe TM and Eddy SR  (1999) A computational screen for methylation guide snoRNAs in yeast. Science 283(5405):1168-71	SGD
SNR56/snR56	IMP: Inferred from Mutant Phenotype, ISM: Inferred from Sequence Model Assigned on 2008-04-16	manually curated	Lowe TM and Eddy SR  (1999) A computational screen for methylation guide snoRNAs in yeast. Science 283(5405):1168-71	SGD
SNR57/snR57	IMP: Inferred from Mutant Phenotype, ISM: Inferred from Sequence Model Assigned on 2008-04-16	manually curated	Lowe TM and Eddy SR  (1999) A computational screen for methylation guide snoRNAs in yeast. Science 283(5405):1168-71	SGD
SNR58/snR58	IMP: Inferred from Mutant Phenotype, ISM: Inferred from Sequence Model Assigned on 2008-04-16	manually curated	Lowe TM and Eddy SR  (1999) A computational screen for methylation guide snoRNAs in yeast. Science 283(5405):1168-71	SGD
SNR59/snR59	ISM: Inferred from Sequence Model Assigned on 2008-04-16	manually curated	Lowe TM and Eddy SR  (1999) A computational screen for methylation guide snoRNAs in yeast. Science 283(5405):1168-71	SGD
SNR60/snR60	IMP: Inferred from Mutant Phenotype, ISM: Inferred from Sequence Model Assigned on 2008-04-16	manually curated	Lowe TM and Eddy SR  (1999) A computational screen for methylation guide snoRNAs in yeast. Science 283(5405):1168-71	SGD
SNR61/snR61	IMP: Inferred from Mutant Phenotype, ISM: Inferred from Sequence Model Assigned on 2008-04-16	manually curated	Lowe TM and Eddy SR  (1999) A computational screen for methylation guide snoRNAs in yeast. Science 283(5405):1168-71	SGD
SNR62/snR62	IMP: Inferred from Mutant Phenotype, ISM: Inferred from Sequence Model Assigned on 2008-04-16	manually curated	Lowe TM and Eddy SR  (1999) A computational screen for methylation guide snoRNAs in yeast. Science 283(5405):1168-71	SGD
SNR63/snR63	IMP: Inferred from Mutant Phenotype, ISM: Inferred from Sequence Model Assigned on 2008-04-16	manually curated	Lowe TM and Eddy SR  (1999) A computational screen for methylation guide snoRNAs in yeast. Science 283(5405):1168-71	SGD

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