Ontology: Biological Process (GO:0031145)

Definition: The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome.

Synonyms: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein breakdown; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolism; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein degradation; APC-dependent proteasomal ubiquitin-dependent protein catabolic process; APC-dependent proteasomal ubiquitin-dependent protein catabolism

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (12 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	12
High-throughput	none	none
Computational (download data)	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	2

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process      12 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
APC1/YNL172W	IMP: Inferred from Mutant Phenotype Assigned on 2011-06-01	manually curated	Thornton BR, et al.  (2006) An architectural map of the anaphase-promoting complex. Genes Dev 20(4):449-60	SGD
APC11/YDL008W	IMP: Inferred from Mutant Phenotype Assigned on 2011-06-01	manually curated	Thornton BR, et al.  (2006) An architectural map of the anaphase-promoting complex. Genes Dev 20(4):449-60	SGD
APC2/YLR127C	IMP: Inferred from Mutant Phenotype Assigned on 2011-06-01	manually curated	Thornton BR, et al.  (2006) An architectural map of the anaphase-promoting complex. Genes Dev 20(4):449-60	SGD
APC4/YDR118W	IMP: Inferred from Mutant Phenotype Assigned on 2011-06-01	manually curated	Thornton BR, et al.  (2006) An architectural map of the anaphase-promoting complex. Genes Dev 20(4):449-60	SGD
APC5/YOR249C	IMP: Inferred from Mutant Phenotype Assigned on 2011-06-01	manually curated	Thornton BR, et al.  (2006) An architectural map of the anaphase-promoting complex. Genes Dev 20(4):449-60	SGD
CDC16/YKL022C	IDA: Inferred from Direct Assay Assigned on 2005-04-04	manually curated	Zachariae W, et al.  (1996) Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae. Science 274(5290):1201-4	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2011-06-01	manually curated	Thornton BR, et al.  (2006) An architectural map of the anaphase-promoting complex. Genes Dev 20(4):449-60	SGD
CDC23/YHR166C	IDA: Inferred from Direct Assay Assigned on 2005-04-04	manually curated	Zachariae W, et al.  (1996) Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae. Science 274(5290):1201-4	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2011-06-01	manually curated	Thornton BR, et al.  (2006) An architectural map of the anaphase-promoting complex. Genes Dev 20(4):449-60	SGD
CDC26/YFR036W	IDA: Inferred from Direct Assay Assigned on 2005-04-04	manually curated	Zachariae W, et al.  (1996) Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae. Science 274(5290):1201-4	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR018860 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CDC27/YBL084C	IDA: Inferred from Direct Assay Assigned on 2005-04-04	manually curated	Zachariae W, et al.  (1996) Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae. Science 274(5290):1201-4	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2011-06-01	manually curated	Thornton BR, et al.  (2006) An architectural map of the anaphase-promoting complex. Genes Dev 20(4):449-60	SGD
DOC1/YGL240W	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2005-04-04	manually curated	Carroll CW and Morgan DO  (2002) The Doc1 subunit is a processivity factor for the anaphase-promoting complex. Nat Cell Biol 4(11):880-7	SGD
MND2/YIR025W	IPI: Inferred from Physical Interaction Assigned on 2005-04-07	manually curated	Hall MC, et al.  (2003) Mnd2 and Swm1 are core subunits of the Saccharomyces cerevisiae anaphase-promoting complex. J Biol Chem 278(19):16698-705	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR008402, EBI:IPR016807 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SWM1/YDR260C	IPI: Inferred from Physical Interaction Assigned on 2005-04-07	manually curated	Hall MC, et al.  (2003) Mnd2 and Swm1 are core subunits of the Saccharomyces cerevisiae anaphase-promoting complex. J Biol Chem 278(19):16698-705	SGD

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