Ontology: Biological Process (GO:0030846)

Definition: The process in which transcription of polyadenylated RNA polymerase II transcripts is terminated; cleavage and polyadenylylation of the mRNA 3' end is coupled to transcription termination.

Synonyms: transcription termination from Pol II promoter, poly(A) coupled; transcription termination from Pol II promoter, RNA polymerase(A) coupled; termination of RNA polymerase II transcription, polyadenylation-coupled

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This table lists the methods used to annotate genes either directly to the term termination of RNA polymerase II transcription, poly(A)-coupled (9 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	termination of RNA polymerase II transcription, poly(A)-coupled	9
High-throughput	none	none
Computational	none	none

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term termination of RNA polymerase II transcription, poly(A)-coupled or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

termination of RNA polymerase II transcription, poly(A)-coupled      9 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
GLC7/YER133W	IPI: Inferred from Physical Interaction Assigned on 2003-10-13	manually curated	Nedea E, et al.  (2003) Organization and function of APT, a subcomplex of the yeast cleavage and polyadenylation factor involved in the formation of mRNA and small nucleolar RNA 3'-ends. J Biol Chem 278(35):33000-10	SGD
PTA1/YAL043C	IPI: Inferred from Physical Interaction Assigned on 2003-10-13	manually curated	Nedea E, et al.  (2003) Organization and function of APT, a subcomplex of the yeast cleavage and polyadenylation factor involved in the formation of mRNA and small nucleolar RNA 3'-ends. J Biol Chem 278(35):33000-10	SGD
PTI1/YGR156W	IPI: Inferred from Physical Interaction Assigned on 2003-10-13	manually curated	Nedea E, et al.  (2003) Organization and function of APT, a subcomplex of the yeast cleavage and polyadenylation factor involved in the formation of mRNA and small nucleolar RNA 3'-ends. J Biol Chem 278(35):33000-10	SGD
RAI1/YGL246C	IMP: Inferred from Mutant Phenotype Assigned on 2005-07-18	manually curated	Kim M, et al.  (2004) The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II. Nature 432(7016):517-22	SGD
RAT1/YOR048C	IMP: Inferred from Mutant Phenotype Assigned on 2005-02-08	manually curated	Kim M, et al.  (2004) The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II. Nature 432(7016):517-22	SGD
REF2/YDR195W	IMP: Inferred from Mutant Phenotype Assigned on 2012-04-05	manually curated	Nedea E, et al.  (2003) Organization and function of APT, a subcomplex of the yeast cleavage and polyadenylation factor involved in the formation of mRNA and small nucleolar RNA 3'-ends. J Biol Chem 278(35):33000-10	SGD
SSU72/YNL222W	IMP: Inferred from Mutant Phenotype Assigned on 2003-10-10	manually curated	Steinmetz EJ and Brow DA  (2003) Ssu72 protein mediates both poly(A)-coupled and poly(A)-independent termination of RNA polymerase II transcription. Mol Cell Biol 23(18):6339-49	SGD
	IPI: Inferred from Physical Interaction Assigned on 2003-10-13	manually curated	Nedea E, et al.  (2003) Organization and function of APT, a subcomplex of the yeast cleavage and polyadenylation factor involved in the formation of mRNA and small nucleolar RNA 3'-ends. J Biol Chem 278(35):33000-10	SGD
SWD2/YKL018W	IPI: Inferred from Physical Interaction Assigned on 2003-10-13	manually curated	Nedea E, et al.  (2003) Organization and function of APT, a subcomplex of the yeast cleavage and polyadenylation factor involved in the formation of mRNA and small nucleolar RNA 3'-ends. J Biol Chem 278(35):33000-10	SGD
SYC1/YOR179C	IPI: Inferred from Physical Interaction Assigned on 2003-10-13	manually curated	Nedea E, et al.  (2003) Organization and function of APT, a subcomplex of the yeast cleavage and polyadenylation factor involved in the formation of mRNA and small nucleolar RNA 3'-ends. J Biol Chem 278(35):33000-10	SGD

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