Ontology: Cellular Component (GO:0030686)

Definition: A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term 90S preribosome (79 genes) or to its variants containing one or more qualifiers (1 gene). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	90S preribosome	14
	colocalizes_with: 90S preribosome	1
High-throughput (download data)	90S preribosome	69
Computational (download data)	90S preribosome	2

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term 90S preribosome or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

colocalizes_with: 90S preribosome      1 gene directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ESF2/YNR054C	IDA: Inferred from Direct Assay Assigned on 2008-05-16	manually curated	Hoang T, et al.  (2005) Esf2p, a U3-associated factor required for small-subunit processome assembly and compaction. Mol Cell Biol 25(13):5523-34	SGD

90S preribosome      79 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
SNR17A/snR17a	IDA: Inferred from Direct Assay Assigned on 2007-09-18	manually curated	Dosil M and Bustelo XR  (2004) Functional characterization of Pwp2, a WD family protein essential for the assembly of the 90 S pre-ribosomal particle. J Biol Chem 279(36):37385-97	SGD
	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
SNR17B/snR17b	IDA: Inferred from Direct Assay Assigned on 2007-09-18	manually curated	Dosil M and Bustelo XR  (2004) Functional characterization of Pwp2, a WD family protein essential for the assembly of the 90 S pre-ribosomal particle. J Biol Chem 279(36):37385-97	SGD
	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
SOF1/YLL011W	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
SPB4/YFL002C	IDA: Inferred from Direct Assay, IPI: Inferred from Physical Interaction with SGD:PWP2, SGD:NOP58 Assigned on 2011-08-25	manually curated	Garcia-Gomez JJ, et al.  (2011) Dynamics of the putative RNA helicase Spb4 during ribosome assembly in Saccharomyces cerevisiae. Mol Cell Biol 31(20):4156-64	SGD
SQS1/YNL224C	IDA: Inferred from Direct Assay Assigned on 2009-12-09	manually curated	Lebaron S, et al.  (2009) The ATPase and helicase activities of Prp43p are stimulated by the G-patch protein Pfa1p during yeast ribosome biogenesis. EMBO J 28(24):3808-19	SGD
TSR1/YDL060W	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
UTP10/YJL109C	IDA: Inferred from Direct Assay Assigned on 2009-06-05	manually curated	Dez C, et al.  (2007) Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation. RNA 13(9):1516-27	SGD
	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
UTP13/YLR222C	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
UTP15/YMR093W	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
UTP18/YJL069C	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
UTP20/YBL004W	IDA: Inferred from Direct Assay Assigned on 2009-06-05	manually curated	Dez C, et al.  (2007) Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation. RNA 13(9):1516-27	SGD
	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
UTP21/YLR409C	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
UTP22/YGR090W	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
UTP30/YKR060W	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
UTP4/YDR324C	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
UTP6/YDR449C	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
UTP7/YER082C	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
UTP8/YGR128C	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
UTP9/YHR196W	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD

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