Ontology: Cellular Component (GO:0030686)

Definition: A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term 90S preribosome (79 genes) or to its variants containing one or more qualifiers (1 gene). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	90S preribosome	14
	colocalizes_with: 90S preribosome	1
High-throughput (download data)	90S preribosome	69
Computational (download data)	90S preribosome	2

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term 90S preribosome or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

colocalizes_with: 90S preribosome      1 gene directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ESF2/YNR054C	IDA: Inferred from Direct Assay Assigned on 2008-05-16	manually curated	Hoang T, et al.  (2005) Esf2p, a U3-associated factor required for small-subunit processome assembly and compaction. Mol Cell Biol 25(13):5523-34	SGD

90S preribosome      79 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
PRP43/YGL120C	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
PWP2/YCR057C	IDA: Inferred from Direct Assay Assigned on 2005-01-26	manually curated	Dosil M and Bustelo XR  (2004) Functional characterization of Pwp2, a WD family protein essential for the assembly of the 90 S pre-ribosomal particle. J Biol Chem 279(36):37385-97	SGD
	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
RCL1/YOL010W	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
ROK1/YGL171W	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
RPP0/YLR340W	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
RPS0A/YGR214W	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
RPS0B/YLR048W	IBA: Inferred from Biological Aspect of Ancestor with PANTHER:PTHR11489_AN0 Assigned on 2011-01-05	computational	Gaudet P, et al.  (2011) Annotation inferences using phylogenetic trees.	RefGenome
RPS11A/YDR025W	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
RPS11B/YBR048W	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
RPS13/YDR064W	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
RPS14A/YCR031C	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
RPS16A/YMR143W	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
RPS1A/YLR441C	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
RPS1B/YML063W	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
RPS3/YNL178W	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
RPS4A/YJR145C	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
RPS4B/YHR203C	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
RPS5/YJR123W	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
RPS6A/YPL090C	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
RPS7A/YOR096W	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
RPS7B/YNL096C	IBA: Inferred from Biological Aspect of Ancestor with PANTHER:PTHR11278_AN0 Assigned on 2011-01-05	computational	Gaudet P, et al.  (2011) Annotation inferences using phylogenetic trees.	RefGenome
RPS8A/YBL072C	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
RPS8B/YER102W	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
RPS9A/YPL081W	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
RPS9B/YBR189W	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
RRP12/YPL012W	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
RRP36/YOR287C	IDA: Inferred from Direct Assay Assigned on 2010-03-31	manually curated	Gerus M, et al.  (2010) Evolutionarily conserved function of RRP36 in early cleavages of the pre-rRNA and production of the 40S ribosomal subunit. Mol Cell Biol 30(5):1130-44	SGD
RRP5/YMR229C	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
RRP9/YPR137W	IDA: Inferred from Direct Assay Assigned on 2012-02-08	high-throughput	Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15	SGD
SLX9/YGR081C	IDA: Inferred from Direct Assay Assigned on 2007-01-30	manually curated	Bax R, et al.  (2006) Slx9p facilitates efficient ITS1 processing of pre-rRNA in Saccharomyces cerevisiae. RNA 12(11):2005-13	SGD

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