Ontology: Biological Process (GO:0030163)

Definition: The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.

Synonyms: protein breakdown; protein catabolism; protein degradation; pheromone catabolism; pheromone catabolic process

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term protein catabolic process (16 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	protein catabolic process	6
High-throughput	none	none
Computational (download data)	protein catabolic process	10

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term protein catabolic process or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

protein catabolic process      16 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
AFG3/YER017C	IEA: Inferred from Electronic Annotation with EBI:IPR005936 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CIC1/YHR052W	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2001-10-26	manually curated	Jager S, et al.  (2001) Cic1, an adaptor protein specifically linking the 26S proteasome to its substrate, the SCF component Cdc4. EMBO J 20(16):4423-31	SGD
LAP2/YNL045W	IDA: Inferred from Direct Assay Assigned on 2003-02-21	manually curated	Kull F, et al.  (1999) Cloning and characterization of a bifunctional leukotriene A(4) hydrolase from Saccharomyces cerevisiae. J Biol Chem 274(49):34683-90	SGD
NMA111/YNL123W	IMP: Inferred from Mutant Phenotype Assigned on 2008-12-02	manually curated	Padmanabhan N, et al.  (2009) The Yeast HtrA Orthologue Ynm3 Is a Protease with Chaperone Activity that Aids Survival Under Heat Stress. Mol Biol Cell 20(1):68-77	SGD
NTA1/YJR062C	IMP: Inferred from Mutant Phenotype Assigned on 2002-06-05	manually curated	Baker RT and Varshavsky A  (1995) Yeast N-terminal amidase. A new enzyme and component of the N-end rule pathway. J Biol Chem 270(20):12065-74	SGD
RPT1/YKL145W	IEA: Inferred from Electronic Annotation with EBI:IPR005937 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
RPT2/YDL007W	IEA: Inferred from Electronic Annotation with EBI:IPR005937 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
RPT3/YDR394W	IEA: Inferred from Electronic Annotation with EBI:IPR005937 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
RPT4/YOR259C	IEA: Inferred from Electronic Annotation with EBI:IPR005937 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
RPT5/YOR117W	IEA: Inferred from Electronic Annotation with EBI:IPR005937 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
RPT6/YGL048C	IEA: Inferred from Electronic Annotation with EBI:IPR005937 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SUE1/YPR151C	IMP: Inferred from Mutant Phenotype Assigned on 2004-09-17	manually curated	Wei J and Sherman F  (2004) Sue1p is required for degradation of labile forms of altered cytochromes C in yeast mitochondria. J Biol Chem 279(29):30449-58	SGD
UBR1/YGR184C	IEA: Inferred from Electronic Annotation with EBI:IPR003769 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
YME1/YPR024W	IEA: Inferred from Electronic Annotation with EBI:IPR005936 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
YSP3/YOR003W	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-08-30	manually curated	Sterky F, et al.  (1996) The sequence of a 30 kb fragment on the left arm of chromosome XV from Saccharomyces cerevisiae reveals 15 open reading frames, five of which correspond to previously identified genes. Yeast 12(10B Suppl):1091-5	SGD
YTA12/YMR089C	IEA: Inferred from Electronic Annotation with EBI:IPR005936 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro

SGD Home About Blog Site Map Help Terms of Use
© Stanford University, Stanford, CA 94305.