GO term: establishment of cell polarity

Ontology: Biological Process (GO:0030010)

Definition: The specification and formation of anisotropic intracellular organization or cell growth patterns.

Synonyms: cell polarization; bud site selection/establishment of cell polarity

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Annotation Summary

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This table lists the methods used to annotate genes either directly to the term establishment of cell polarity (29 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	establishment of cell polarity	29
High-throughput	none	none
Computational	none	none

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Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Genes Annotated with this Term

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Annotation details for genes that have been directly annotated to the term establishment of cell polarity or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

establishment of cell polarity 29 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ACT1/YFL039C	IGI: Inferred from Genetic Interaction with SGD:TPM2, SGD:TPM1 Assigned on 2013-04-10	manually curated	Pruyne DW, et al. (1998) Tropomyosin-containing actin cables direct the Myo2p-dependent polarized delivery of secretory vesicles in budding yeast. J Cell Biol 143(7):1931-45	SGD
BCK1/YJL095W	IMP: Inferred from Mutant Phenotype Assigned on 2001-03-02	manually curated	Costigan C, et al. (1992) A synthetic lethal screen identifies SLK1, a novel protein kinase homolog implicated in yeast cell morphogenesis and cell growth. Mol Cell Biol 12(3):1162-78	SGD
BEM2/YER155C	TAS: Traceable Author Statement Assigned on 2001-03-02	manually curated	Madden K and Snyder M (1998) Cell polarity and morphogenesis in budding yeast. Annu Rev Microbiol 52():687-744	SGD
BEM3/YPL115C	TAS: Traceable Author Statement Assigned on 2001-03-02	manually curated	Madden K and Snyder M (1998) Cell polarity and morphogenesis in budding yeast. Annu Rev Microbiol 52():687-744	SGD
BEM4/YPL161C	IMP: Inferred from Mutant Phenotype Assigned on 2001-03-02	manually curated	Mack D, et al. (1996) Identification of the bud emergence gene BEM4 and its interactions with rho-type GTPases in Saccharomyces cerevisiae. Mol Cell Biol 16(8):4387-95	SGD
BOI2/YER114C	TAS: Traceable Author Statement Assigned on 2001-03-02	manually curated	Pruyne D and Bretscher A (2000) Polarization of cell growth in yeast. I. Establishment and maintenance of polarity states. J Cell Sci 113 ( Pt 3):365-75	SGD
BUD6/YLR319C	IMP: Inferred from Mutant Phenotype Assigned on 2012-11-14	manually curated	Amberg DC, et al. (1997) Aip3p/Bud6p, a yeast actin-interacting protein that is involved in morphogenesis and the selection of bipolar budding sites. Mol Biol Cell 8(4):729-53	SGD
CDC24/YAL041W	TAS: Traceable Author Statement Assigned on 2001-03-02	manually curated	Madden K and Snyder M (1998) Cell polarity and morphogenesis in budding yeast. Annu Rev Microbiol 52():687-744	SGD
CDC42/YLR229C	IMP: Inferred from Mutant Phenotype Assigned on 2013-04-25	manually curated	Meitinger F, et al. (2013) A safeguard mechanism regulates Rho GTPases to coordinate cytokinesis with the establishment of cell polarity. PLoS Biol 11(2):e1001495	SGD
CDC43/YGL155W	TAS: Traceable Author Statement Assigned on 2001-03-02	manually curated	Madden K and Snyder M (1998) Cell polarity and morphogenesis in budding yeast. Annu Rev Microbiol 52():687-744	SGD
CLA4/YNL298W	TAS: Traceable Author Statement Assigned on 2001-03-02	manually curated	Pruyne D and Bretscher A (2000) Polarization of cell growth in yeast. J Cell Sci 113 ( Pt 4):571-85	SGD
GIC1/YHR061C	IGI: Inferred from Genetic Interaction with SGD:GIC2 Assigned on 2008-09-12	manually curated	Brown JL, et al. (1997) Novel Cdc42-binding proteins Gic1 and Gic2 control cell polarity in yeast. Genes Dev 11(22):2972-82	SGD
GIC2/YDR309C	IGI: Inferred from Genetic Interaction with SGD:GIC1 Assigned on 2008-09-12	manually curated	Brown JL, et al. (1997) Novel Cdc42-binding proteins Gic1 and Gic2 control cell polarity in yeast. Genes Dev 11(22):2972-82	SGD
MSB1/YOR188W	IGI: Inferred from Genetic Interaction Assigned on 2002-11-01	manually curated	Bi E, et al. (2000) Identification of novel, evolutionarily conserved Cdc42p-interacting proteins and of redundant pathways linking Cdc24p and Cdc42p to actin polarization in yeast. Mol Biol Cell 11(2):773-93	SGD
MSB2/YGR014W	IGI: Inferred from Genetic Interaction with SGD:CDC24 Assigned on 2011-03-22	manually curated	Bender A and Pringle JR (1989) Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1. Proc Natl Acad Sci U S A 86(24):9976-80	SGD
MSB2/YGR014W	IMP: Inferred from Mutant Phenotype Assigned on 2011-03-22	manually curated	Pitoniak A, et al. (2009) The signaling mucins Msb2 and Hkr1 differentially regulate the filamentation mitogen-activated protein kinase pathway and contribute to a multimodal response. Mol Biol Cell 20(13):3101-14	SGD
PEA2/YER149C	TAS: Traceable Author Statement Assigned on 2001-03-02	manually curated	Pruyne D and Bretscher A (2000) Polarization of cell growth in yeast. I. Establishment and maintenance of polarity states. J Cell Sci 113 ( Pt 3):365-75	SGD
PWP2/YCR057C	IMP: Inferred from Mutant Phenotype Assigned on 2001-03-02	manually curated	Shafaatian R, et al. (1996) PWP2, a member of the WD-repeat family of proteins, is an essential Saccharomyces cerevisiae gene involved in cell separation. Mol Gen Genet 252(1-2):101-14	SGD
RGA1/YOR127W	IMP: Inferred from Mutant Phenotype Assigned on 2008-01-11	manually curated	Tong Z, et al. (2007) Adjacent positioning of cellular structures enabled by a Cdc42 GTPase-activating protein-mediated zone of inhibition. J Cell Biol 179(7):1375-84	SGD
RGA2/YDR379W	TAS: Traceable Author Statement Assigned on 2001-03-02	manually curated	Madden K and Snyder M (1998) Cell polarity and morphogenesis in budding yeast. Annu Rev Microbiol 52():687-744	SGD
RHO2/YNL090W	TAS: Traceable Author Statement Assigned on 2001-03-02	manually curated	Madden K and Snyder M (1998) Cell polarity and morphogenesis in budding yeast. Annu Rev Microbiol 52():687-744	SGD
ROM2/YLR371W	IMP: Inferred from Mutant Phenotype Assigned on 2011-04-23	manually curated	Manning BD, et al. (1997) The Rho-GEF Rom2p localizes to sites of polarized cell growth and participates in cytoskeletal functions in Saccharomyces cerevisiae. Mol Biol Cell 8(10):1829-44	SGD
SHO1/YER118C	IGI: Inferred from Genetic Interaction with SGD:MSB2 Assigned on 2011-03-22	manually curated	Pitoniak A, et al. (2009) The signaling mucins Msb2 and Hkr1 differentially regulate the filamentation mitogen-activated protein kinase pathway and contribute to a multimodal response. Mol Biol Cell 20(13):3101-14	SGD
SLG1/YOR008C	IMP: Inferred from Mutant Phenotype Assigned on 2001-03-02	manually curated	Delley PA and Hall MN (1999) Cell wall stress depolarizes cell growth via hyperactivation of RHO1. J Cell Biol 147(1):163-74	SGD
SRO7/YPR032W	IPI: Inferred from Physical Interaction with SGD:SEC9, SGD:MYO2 Assigned on 2006-01-18	manually curated	Gangar A, et al. (2005) Structurally conserved interaction of Lgl family with SNAREs is critical to their cellular function. Curr Biol 15(12):1136-42	SGD
SWF1/YDR126W	IMP: Inferred from Mutant Phenotype Assigned on 2009-04-06	manually curated	Dighe SA and Kozminski KG (2008) Swf1p, a member of the DHHC-CRD family of palmitoyltransferases, regulates the actin cytoskeleton and polarized secretion independently of its DHHC motif. Mol Biol Cell 19(10):4454-68	SGD
TPM1/YNL079C	TAS: Traceable Author Statement Assigned on 2001-03-02	manually curated	Pruyne D and Bretscher A (2000) Polarization of cell growth in yeast. J Cell Sci 113 ( Pt 4):571-85	SGD
TPM2/YIL138C	TAS: Traceable Author Statement Assigned on 2001-03-02	manually curated	Pruyne D and Bretscher A (2000) Polarization of cell growth in yeast. J Cell Sci 113 ( Pt 4):571-85	SGD
ZDS1/YMR273C	IGI: Inferred from Genetic Interaction with SGD:CDC42, SGD:ZDS2, SGD:CDC24, IMP: Inferred from Mutant Phenotype Assigned on 2010-01-06	manually curated	Bi E and Pringle JR (1996) ZDS1 and ZDS2, genes whose products may regulate Cdc42p in Saccharomyces cerevisiae. Mol Cell Biol 16(10):5264-75	SGD
ZDS2/YML109W	IGI: Inferred from Genetic Interaction with SGD:ZDS1 Assigned on 2010-01-06	manually curated	Bi E and Pringle JR (1996) ZDS1 and ZDS2, genes whose products may regulate Cdc42p in Saccharomyces cerevisiae. Mol Cell Biol 16(10):5264-75	SGD

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