Ontology: Molecular Function (GO:0000250)

Definition: Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus.

Synonyms: 2,3-epoxysqualene--lanosterol cyclase activity; OSC; oxidosqualene--lanosterol cyclase activity; squalene-2,3-oxide-lanosterol cyclase activity; (S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming); 2,3-oxidosqualene-lanosterol cyclase activity; 2,3-epoxysqualene lanosterol cyclase activity; 2,3-epoxysqualene-lanosterol cyclase activity; 2,3-oxidosqualene sterol cyclase activity; squalene epoxidase-cyclase activity; lanosterol 2,3-oxidosqualene cyclase activity; oxidosqualene-lanosterol cyclase activity; squalene 2,3-epoxide:lanosterol cyclase activity; oxidosqualene:lanosterol cyclase activity

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term lanosterol synthase activity (1 gene) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	lanosterol synthase activity	1
High-throughput	none	none
Computational (download data)	lanosterol synthase activity	1

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term lanosterol synthase activity or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

lanosterol synthase activity      1 gene directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ERG7/YHR072W	IMP: Inferred from Mutant Phenotype Assigned on 2009-02-20	manually curated	Wu TK, et al.  (2008) Importance of Saccharomyces cerevisiae Oxidosqualene-Lanosterol Cyclase Tyrosine 707 Residue for Chair-Boat Bicyclic Ring Formation and Deprotonation Reactions. Org Lett 10(21):4959-62	SGD
	IEA: Inferred from Electronic Annotation with IUBMB:5.4.99.7 Last Updated 2013-03-02	computational	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB

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