Ontology: Biological Process (GO:0019354)

Definition: The chemical reactions and pathways resulting in the formation of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings.

Synonyms: sirohaem biosynthesis; sirohaem biosynthetic process; siroheme anabolism; siroheme biosynthesis; siroheme formation; siroheme synthase activity; siroheme synthesis

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term siroheme biosynthetic process (2 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	siroheme biosynthetic process	2
High-throughput	none	none
Computational (download data)	siroheme biosynthetic process	2

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term siroheme biosynthetic process or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

siroheme biosynthetic process      2 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
MET1/YKR069W	IGI: Inferred from Genetic Interaction, ISS: Inferred from Sequence or structural Similarity Assigned on 2003-09-22	manually curated	Hansen J, et al.  (1997) Siroheme biosynthesis in Saccharomyces cerevisiae requires the products of both the MET1 and MET8 genes. FEBS Lett 401(1):20-4	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR012066 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
MET8/YBR213W	IMP: Inferred from Mutant Phenotype Assigned on 2002-11-14	manually curated	Hansen J, et al.  (1997) Siroheme biosynthesis in Saccharomyces cerevisiae requires the products of both the MET1 and MET8 genes. FEBS Lett 401(1):20-4	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR006367 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with UniPathway:UPA00262 Last Updated 2013-03-02	computational	UniProt-GOA  (2012) Gene Ontology annotation based on UniPathway vocabulary mapping.	UniPathway

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