GO term: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 
Ontology: Biological Process (GO:0000184)
Definition: The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
Synonyms: mRNA breakdown, nonsense-mediated decay; mRNA catabolic process, nonsense-mediated; mRNA catabolism, nonsense-mediated; mRNA degradation, nonsense-mediated decay; nonsense-mediated mRNA decay; nuclear mRNA catabolic process, nonsense-mediated decay
View Ontology:
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(text)
Definition: The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
Synonyms: mRNA breakdown, nonsense-mediated decay; mRNA catabolic process, nonsense-mediated; mRNA catabolism, nonsense-mediated; mRNA degradation, nonsense-mediated decay; nonsense-mediated mRNA decay; nuclear mRNA catabolic process, nonsense-mediated decay
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (17 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 7 |
| High-throughput | none | none |
| Computational (download data) | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 14 |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 17 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| CBC2/YPL178W | IEA: Inferred from Electronic Annotation with EBI:KW-0866 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| CDC33/YOL139C | IDA: Inferred from Direct Assay, IPI: Inferred from Physical Interaction Assigned on 2005-03-15 |
manually curated | Gao Q, et al. (2005) Cap-binding protein 1-mediated and eukaryotic translation initiation factor 4E-mediated pioneer rounds of translation in yeast. Proc Natl Acad Sci U S A 102(12):4258-63 |
SGD |
| DBP2/YNL112W | IPI: Inferred from Physical Interaction with SGD:NAM7 Assigned on 2003-09-22 |
manually curated | He F and Jacobson A (1995) Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen. Genes Dev 9(4):437-54 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0866 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| DCP1/YOL149W | IEA: Inferred from Electronic Annotation with EBI:KW-0866 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| DCP2/YNL118C | IEA: Inferred from Electronic Annotation with EBI:KW-0866 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| DCS2/YOR173W | IEA: Inferred from Electronic Annotation with EBI:KW-0866 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| EBS1/YDR206W | IMP: Inferred from Mutant Phenotype Assigned on 2008-01-13 |
manually curated | Luke B, et al. (2007) Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay. Nucleic Acids Res 35(22):7688-97 |
SGD |
| EDC1/YGL222C | IEA: Inferred from Electronic Annotation with EBI:KW-0866 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| EDC2/YER035W | IEA: Inferred from Electronic Annotation with EBI:KW-0866 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| HRP1/YOL123W | IEA: Inferred from Electronic Annotation with EBI:KW-0866 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| NAM7/YMR080C | TAS: Traceable Author Statement Assigned on 2002-01-27 |
manually curated | Culbertson MR (1999) RNA surveillance. Unforeseen consequences for gene expression, inherited genetic disorders and cancer. Trends Genet 15(2):74-80 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR018999 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0866 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| NMD4/YLR363C | IPI: Inferred from Physical Interaction Assigned on 2002-11-19 |
manually curated | He F and Jacobson A (1995) Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen. Genes Dev 9(4):437-54 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0866 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| PUB1/YNL016W | IDA: Inferred from Direct Assay Assigned on 2003-01-10 |
manually curated | Ruiz-Echevarria MJ and Peltz SW (2000) The RNA binding protein Pub1 modulates the stability of transcripts containing upstream open reading frames. Cell 101(7):741-51 |
SGD |
| SKI7/YOR076C | IEA: Inferred from Electronic Annotation with EBI:KW-0866 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| STO1/YMR125W | IDA: Inferred from Direct Assay, IPI: Inferred from Physical Interaction Assigned on 2005-03-15 |
manually curated | Gao Q, et al. (2005) Cap-binding protein 1-mediated and eukaryotic translation initiation factor 4E-mediated pioneer rounds of translation in yeast. Proc Natl Acad Sci U S A 102(12):4258-63 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0866 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| UPF3/YGR072W | IEA: Inferred from Electronic Annotation with EBI:KW-0866 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| XRN1/YGL173C | IEA: Inferred from Electronic Annotation with EBI:KW-0866 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
