Ontology: Cellular Component (GO:0000172)

Definition: A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication.

Synonyms: ribonuclease mitochondrial RNA processing complex; RNase MRP complex

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term ribonuclease MRP complex (11 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	ribonuclease MRP complex	11
High-throughput	none	none
Computational (download data)	ribonuclease MRP complex	1

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term ribonuclease MRP complex or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

ribonuclease MRP complex      11 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
NME1	IDA: Inferred from Direct Assay Assigned on 2007-03-01	manually curated	Schmitt ME and Clayton DA  (1992) Yeast site-specific ribonucleoprotein endoribonuclease MRP contains an RNA component homologous to mammalian RNase MRP RNA and essential for cell viability. Genes Dev 6(10):1975-85	SGD
POP1/YNL221C	TAS: Traceable Author Statement Assigned on 2001-01-18	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
POP3/YNL282W	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
	IPI: Inferred from Physical Interaction with SGD:NME1 Assigned on 2006-11-21	manually curated	Dichtl B and Tollervey D  (1997) Pop3p is essential for the activity of the RNase MRP and RNase P ribonucleoproteins in vivo. EMBO J 16(2):417-29	SGD
POP4/YBR257W	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR016848, EBI:IPR002730 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
POP5/YAL033W	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
POP6/YGR030C	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
POP7/YBR167C	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
POP8/YBL018C	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
RMP1/YLR145W	IDA: Inferred from Direct Assay Assigned on 2005-02-08	manually curated	Salinas K, et al.  (2005) Characterization and purification of Saccharomyces cerevisiae RNase MRP reveals a new unique protein component. J Biol Chem 280(12):11352-60	SGD
RPP1/YHR062C	IDA: Inferred from Direct Assay Assigned on 2006-11-21	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
	IPI: Inferred from Physical Interaction with SGD:NME1 Assigned on 2006-11-21	manually curated	Stolc V and Altman S  (1997) Rpp1, an essential protein subunit of nuclear RNase P required for processing of precursor tRNA and 35S precursor rRNA in Saccharomyces cerevisiae. Genes Dev 11(21):2926-37	SGD
SNM1/YDR478W	TAS: Traceable Author Statement Assigned on 2007-03-01	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD

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