Ontology: Molecular Function (GO:0000171)

Definition: Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA.

Synonyms: RNase MRP

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term ribonuclease MRP activity (0 genes) or to its variants containing one or more qualifiers (11 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	contributes_to: ribonuclease MRP activity	11
High-throughput	none	none
Computational	none	none

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term ribonuclease MRP activity or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

contributes_to: ribonuclease MRP activity      11 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
NME1	IMP: Inferred from Mutant Phenotype Assigned on 2007-03-01	manually curated	Chu S, et al.  (1994) The RNA of RNase MRP is required for normal processing of ribosomal RNA. Proc Natl Acad Sci U S A 91(2):659-63	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2007-03-01	manually curated	Lygerou Z, et al.  (1996) Accurate processing of a eukaryotic precursor ribosomal RNA by ribonuclease MRP in vitro. Science 272(5259):268-70	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2007-03-01	manually curated	Schmitt ME and Clayton DA  (1993) Nuclear RNase MRP is required for correct processing of pre-5.8S rRNA in Saccharomyces cerevisiae. Mol Cell Biol 13(12):7935-41	SGD
POP1/YNL221C	IMP: Inferred from Mutant Phenotype Assigned on 2006-11-16	manually curated	Xiao S, et al.  (2006) Functional characterization of the conserved amino acids in Pop1p, the largest common protein subunit of yeast RNases P and MRP. RNA 12(6):1023-37	SGD
POP3/YNL282W	IDA: Inferred from Direct Assay Assigned on 2006-11-21	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2006-11-21	manually curated	Dichtl B and Tollervey D  (1997) Pop3p is essential for the activity of the RNase MRP and RNase P ribonucleoproteins in vivo. EMBO J 16(2):417-29	SGD
POP4/YBR257W	IDA: Inferred from Direct Assay Assigned on 2006-11-21	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2006-11-21	manually curated	Chu S, et al.  (1997) A novel protein shared by RNase MRP and RNase P. RNA 3(4):382-91	SGD
POP5/YAL033W	IMP: Inferred from Mutant Phenotype Assigned on 2006-11-16	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
POP6/YGR030C	IMP: Inferred from Mutant Phenotype Assigned on 2006-11-16	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
POP7/YBR167C	IMP: Inferred from Mutant Phenotype Assigned on 2006-11-16	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
POP8/YBL018C	IMP: Inferred from Mutant Phenotype Assigned on 2006-11-16	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
RMP1/YLR145W	IPI: Inferred from Physical Interaction Assigned on 2007-03-09	manually curated	Salinas K, et al.  (2005) Characterization and purification of Saccharomyces cerevisiae RNase MRP reveals a new unique protein component. J Biol Chem 280(12):11352-60	SGD
RPP1/YHR062C	IDA: Inferred from Direct Assay Assigned on 2006-11-21	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2006-11-21	manually curated	Stolc V and Altman S  (1997) Rpp1, an essential protein subunit of nuclear RNase P required for processing of precursor tRNA and 35S precursor rRNA in Saccharomyces cerevisiae. Genes Dev 11(21):2926-37	SGD
SNM1/YDR478W	TAS: Traceable Author Statement Assigned on 2007-03-01	manually curated	Chamberlain JR, et al.  (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90	SGD

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