GO term: ATPase activity 
Ontology: Molecular Function (GO:0016887)
Definition: Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
Synonyms: ATP monophosphatase activity; adenosinetriphosphatase activity; ATP phosphohydrolase activity; ATP hydrolase activity; (Ca2+ + Mg2+)-ATPase; adenosine 5'-triphosphatase activity; adenosine triphosphatase activity; complex V (mitochondrial electron transport); HCO3--ATPase; SV40 T-antigen
View Ontology:
(graph) | 
(text)
Definition: Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
Synonyms: ATP monophosphatase activity; adenosinetriphosphatase activity; ATP phosphohydrolase activity; ATP hydrolase activity; (Ca2+ + Mg2+)-ATPase; adenosine 5'-triphosphatase activity; adenosine triphosphatase activity; complex V (mitochondrial electron transport); HCO3--ATPase; SV40 T-antigen
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
ATPase activity (98 genes)
or to its variants containing one or more
qualifiers (17 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | ATPase activity | 67 |
| contributes_to: ATPase activity | 17 | |
| High-throughput | none | none |
| Computational (download data) | ATPase activity | 41 |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
ATPase activity or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| ATPase activity 98 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| ADP1/YCR011C | IEA: Inferred from Electronic Annotation with EBI:IPR017871, EBI:IPR003439 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| AFG2/YLR397C | IDA: Inferred from Direct Assay Assigned on 2002-10-09 |
manually curated | Zakalskiy A, et al. (2002) Structural and enzymatic properties of the AAA protein Drg1p from Saccharomyces cerevisiae. Decoupling of intracellular function from ATPase activity and hexamerization. J Biol Chem 277(30):26788-95 |
SGD |
| AFG3/YER017C | ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18 |
manually curated | Guelin E, et al. (1994) Sequence of the AFG3 gene encoding a new member of the FtsH/Yme1/Tma subfamily of the AAA-protein family. Yeast 10(10):1389-94 |
SGD |
| IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2011-03-03 |
manually curated | Augustin S, et al. (2009) An intersubunit signaling network coordinates ATP hydrolysis by m-AAA proteases. Mol Cell 35(5):574-85 |
SGD | |
| ARB1/YER036C | IEA: Inferred from Electronic Annotation with EBI:IPR017871, EBI:IPR003439 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| ARP2/YDL029W | IMP: Inferred from Mutant Phenotype Assigned on 2008-12-01 |
manually curated | Martin AC, et al. (2006) Arp2/3 ATP hydrolysis-catalysed branch dissociation is critical for endocytic force generation. Nat Cell Biol 8(8):826-33 |
SGD |
| ATM1/YMR301C | IDA: Inferred from Direct Assay Assigned on 2009-04-10 |
manually curated | Kuhnke G, et al. (2006) Stimulation of the ATPase activity of the yeast mitochondrial ABC transporter Atm1p by thiol compounds. Mol Membr Biol 23(2):173-84 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR017871, EBI:IPR003439 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| AUS1/YOR011W | IEA: Inferred from Electronic Annotation with EBI:IPR017871, EBI:IPR003439 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| BCS1/YDR375C | ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18 |
manually curated | Nobrega FG, et al. (1992) BCS1, a novel gene required for the expression of functional Rieske iron-sulfur protein in Saccharomyces cerevisiae. EMBO J 11(11):3821-9 |
SGD |
| BPT1/YLL015W | IEA: Inferred from Electronic Annotation with EBI:IPR003439, EBI:IPR017871 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| CAF16/YFL028C | ISS: Inferred from Sequence or structural Similarity Assigned on 2005-07-26 |
manually curated | Bauer BE, et al. (1999) Inventory and function of yeast ABC proteins: about sex, stress, pleiotropic drug and heavy metal resistance. Biochim Biophys Acta 1461(2):217-36 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR003439 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| CDC48/YDL126C | IDA: Inferred from Direct Assay Assigned on 2001-01-18 |
manually curated | Frohlich KU, et al. (1995) The ATPase activity of purified CDC48p from Saccharomyces cerevisiae shows complex dependence on ATP-, ADP-, and NADH-concentrations and is completely inhibited by NEM. Biochim Biophys Acta 1253(1):25-32 |
SGD |
| CDC6/YJL194W | IDA: Inferred from Direct Assay Assigned on 2007-08-10 |
manually curated | Zwerschke W, et al. (1994) The Saccharomyces cerevisiae CDC6 gene is transcribed at late mitosis and encodes a ATP/GTPase controlling S phase initiation. J Biol Chem 269(37):23351-6 |
SGD |
| CFD1/YIL003W | TAS: Traceable Author Statement Assigned on 2003-12-29 |
manually curated | Roy A, et al. (2003) A novel eukaryotic factor for cytosolic Fe-S cluster assembly. EMBO J 22(18):4826-35 |
SGD |
| DBP8/YHR169W | IDA: Inferred from Direct Assay Assigned on 2008-05-16 |
manually curated | Granneman S, et al. (2006) The nucleolar protein Esf2 interacts directly with the DExD/H box RNA helicase, Dbp8, to stimulate ATP hydrolysis. Nucleic Acids Res 34(10):3189-99 |
SGD |
| DDR48/YMR173W | IDA: Inferred from Direct Assay Assigned on 2004-04-19 |
manually curated | Sheng S and Schuster SM (1993) Purification and characterization of Saccharomyces cerevisiae DNA damage-responsive protein 48 (DDRP 48). J Biol Chem 268(7):4752-8 |
SGD |
| DYN1/YKR054C | IEA: Inferred from Electronic Annotation with EBI:IPR011704 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| ECM3/YOR092W | ISS: Inferred from Sequence or structural Similarity Assigned on 2003-02-06 |
manually curated | Voss H, et al. (1997) DNA sequencing and analysis of 130 kb from yeast chromosome XV. Yeast 13(7):655-72 |
SGD |
| GCN20/YFR009W | ISS: Inferred from Sequence or structural Similarity Assigned on 2005-03-10 |
manually curated | Vazquez de Aldana CR, et al. (1995) GCN20, a novel ATP binding cassette protein, and GCN1 reside in a complex that mediates activation of the eIF-2 alpha kinase GCN2 in amino acid-starved cells. EMBO J 14(13):3184-99 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR017871, EBI:IPR003439 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| GET3/YDL100C | IDA: Inferred from Direct Assay Assigned on 2004-01-07 |
manually curated | Shen J, et al. (2003) The Saccharomyces cerevisiae Arr4p is involved in metal and heat tolerance. Biometals 16(3):369-78 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR016300 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| HEF3/YNL014W | IDA: Inferred from Direct Assay Assigned on 2002-10-09 |
manually curated | Sarthy AV, et al. (1998) Identification and kinetic analysis of a functional homolog of elongation factor 3, YEF3 in Saccharomyces cerevisiae. Yeast 14(3):239-53 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR003439, EBI:IPR017871 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| HSC82/YMR186W | IDA: Inferred from Direct Assay Assigned on 2011-03-16 |
manually curated | Cunningham CN, et al. (2008) Intra- and intermonomer interactions are required to synergistically facilitate ATP hydrolysis in Hsp90. J Biol Chem 283(30):21170-8 |
SGD |
| HSP150/YJL159W | IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2011-04-18 |
manually curated | Suntio T, et al. (2011) ATPase activity of a yeast secretory glycoprotein allows ER exit during inactivation of COPII components Sec24p and Sec13p. Yeast 28(6):453-65 |
SGD |
| HSP60/YLR259C | IDA: Inferred from Direct Assay Assigned on 2008-07-17 |
manually curated | Dubaquie Y, et al. (1997) Significance of chaperonin 10-mediated inhibition of ATP hydrolysis by chaperonin 60. Proc Natl Acad Sci U S A 94(17):9011-6 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2008-07-16 |
manually curated | Rospert S, et al. (1993) Identification and functional analysis of chaperonin 10, the groES homolog from yeast mitochondria. Proc Natl Acad Sci U S A 90(23):10967-71 |
SGD | |
| HSP78/YDR258C | IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2009-01-23 |
manually curated | Krzewska J, et al. (2001) Importance of two ATP-binding sites for oligomerization, ATPase activity and chaperone function of mitochondrial Hsp78 protein. J Mol Biol 314(4):901-10 |
SGD |
| INO80/YGL150C | IDA: Inferred from Direct Assay Assigned on 2002-10-11 |
manually curated | Shen X, et al. (2000) A chromatin remodelling complex involved in transcription and DNA processing. Nature 406(6795):541-4 |
SGD |
| KAR2/YJL034W | IDA: Inferred from Direct Assay Assigned on 2002-11-26 |
manually curated | Tokunaga M, et al. (1992) Purification and characterization of BiP/Kar2 protein from Saccharomyces cerevisiae. J Biol Chem 267(25):17553-9 |
SGD |
| LHS1/YKL073W | IEA: Inferred from Electronic Annotation with IUBMB:3.6.1.3 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
UniProtKB |
| MDL1/YLR188W | IDA: Inferred from Direct Assay Assigned on 2003-07-30 |
manually curated | Janas E, et al. (2003) The ATP hydrolysis cycle of the nucleotide-binding domain of the mitochondrial ATP-binding cassette transporter Mdl1p. J Biol Chem 278(29):26862-9 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR017871, EBI:IPR003439 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| MDL2/YPL270W | IEA: Inferred from Electronic Annotation with EBI:IPR017871, EBI:IPR003439 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| MDN1/YLR106C | ISS: Inferred from Sequence or structural Similarity Assigned on 2002-07-15 |
manually curated | Garbarino J and Gibbons I (2002) Expression and genomic analysis of midasin, a novel and highly conserved AAA protein distantly related to dynein. BMC Genomics 3(1):18 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR011704 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| contributes_to: ATPase activity 17 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| ATP1/YBL099W | IDA: Inferred from Direct Assay Assigned on 2008-09-05 |
manually curated | Lau WC, et al. (2008) Cryo-EM structure of the yeast ATP synthase. J Mol Biol 382(5):1256-64 |
SGD |
| ATP14/YLR295C | IDA: Inferred from Direct Assay Assigned on 2008-09-05 |
manually curated | Lau WC, et al. (2008) Cryo-EM structure of the yeast ATP synthase. J Mol Biol 382(5):1256-64 |
SGD |
| ATP15/YPL271W | IDA: Inferred from Direct Assay Assigned on 2008-09-05 |
manually curated | Lau WC, et al. (2008) Cryo-EM structure of the yeast ATP synthase. J Mol Biol 382(5):1256-64 |
SGD |
| ATP16/YDL004W | IDA: Inferred from Direct Assay Assigned on 2008-09-05 |
manually curated | Lau WC, et al. (2008) Cryo-EM structure of the yeast ATP synthase. J Mol Biol 382(5):1256-64 |
SGD |
| ATP17/YDR377W | IDA: Inferred from Direct Assay Assigned on 2008-09-05 |
manually curated | Lau WC, et al. (2008) Cryo-EM structure of the yeast ATP synthase. J Mol Biol 382(5):1256-64 |
SGD |
| ATP2/YJR121W | IDA: Inferred from Direct Assay Assigned on 2008-09-05 |
manually curated | Lau WC, et al. (2008) Cryo-EM structure of the yeast ATP synthase. J Mol Biol 382(5):1256-64 |
SGD |
| ATP6/Q0085 | IDA: Inferred from Direct Assay Assigned on 2008-09-05 |
manually curated | Lau WC, et al. (2008) Cryo-EM structure of the yeast ATP synthase. J Mol Biol 382(5):1256-64 |
SGD |
| ATP7/YKL016C | IDA: Inferred from Direct Assay Assigned on 2008-09-05 |
manually curated | Lau WC, et al. (2008) Cryo-EM structure of the yeast ATP synthase. J Mol Biol 382(5):1256-64 |
SGD |
| ELP4/YPL101W | IDA: Inferred from Direct Assay Assigned on 2012-03-07 |
manually curated | Glatt S, et al. (2012) The Elongator subcomplex Elp456 is a hexameric RecA-like ATPase.LID - 10.1038/nsmb.2234 [doi] Nat Struct Mol Biol () |
SGD |
| ELP6/YMR312W | IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2012-03-07 |
manually curated | Glatt S, et al. (2012) The Elongator subcomplex Elp456 is a hexameric RecA-like ATPase.LID - 10.1038/nsmb.2234 [doi] Nat Struct Mol Biol () |
SGD |
| IKI1/YHR187W | IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2012-03-07 |
manually curated | Glatt S, et al. (2012) The Elongator subcomplex Elp456 is a hexameric RecA-like ATPase.LID - 10.1038/nsmb.2234 [doi] Nat Struct Mol Biol () |
SGD |
| IOC2/YLR095C | IDA: Inferred from Direct Assay Assigned on 2009-03-20 |
manually curated | Vary JC Jr, et al. (2003) Yeast Isw1p forms two separable complexes in vivo. Mol Cell Biol 23(1):80-91 |
SGD |
| IOC3/YFR013W | IDA: Inferred from Direct Assay Assigned on 2009-03-20 |
manually curated | Vary JC Jr, et al. (2003) Yeast Isw1p forms two separable complexes in vivo. Mol Cell Biol 23(1):80-91 |
SGD |
| IOC4/YMR044W | IDA: Inferred from Direct Assay Assigned on 2009-03-20 |
manually curated | Vary JC Jr, et al. (2003) Yeast Isw1p forms two separable complexes in vivo. Mol Cell Biol 23(1):80-91 |
SGD |
| ISW1/YBR245C | IDA: Inferred from Direct Assay Assigned on 2009-03-20 |
manually curated | Vary JC Jr, et al. (2003) Yeast Isw1p forms two separable complexes in vivo. Mol Cell Biol 23(1):80-91 |
SGD |
| MCM3/YEL032W | IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2007-08-15 |
manually curated | Davey MJ, et al. (2003) Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture. J Biol Chem 278(7):4491-9 |
SGD |
| OLI1/Q0130 | IDA: Inferred from Direct Assay Assigned on 2008-09-05 |
manually curated | Lau WC, et al. (2008) Cryo-EM structure of the yeast ATP synthase. J Mol Biol 382(5):1256-64 |
SGD |
