GO term: histone acetylation 
Ontology: Biological Process (GO:0016573)
Definition: The modification of a histone by the addition of an acetyl group.
View Ontology:
(graph) | 
(text)
Definition: The modification of a histone by the addition of an acetyl group.
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
histone acetylation (43 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | histone acetylation | 40 |
| High-throughput (download data) | histone acetylation | 1 |
| Computational (download data) | histone acetylation | 4 |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
histone acetylation or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| histone acetylation 43 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| ACS1/YAL054C | IGI: Inferred from Genetic Interaction with SGD:ACS2 Assigned on 2006-11-07 |
manually curated | Takahashi H, et al. (2006) Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription. Mol Cell 23(2):207-17 |
SGD |
| ACS2/YLR153C | IMP: Inferred from Mutant Phenotype Assigned on 2006-11-07 |
manually curated | Takahashi H, et al. (2006) Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription. Mol Cell 23(2):207-17 |
SGD |
| ACT1/YFL039C | IDA: Inferred from Direct Assay Assigned on 2002-09-18 |
manually curated | Galarneau L, et al. (2000) Multiple links between the NuA4 histone acetyltransferase complex and epigenetic control of transcription. Mol Cell 5(6):927-37 |
SGD |
| AHC1/YOR023C | IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2005-05-12 |
manually curated | Eberharter A, et al. (1999) The ADA complex is a distinct histone acetyltransferase complex in Saccharomyces cerevisiae. Mol Cell Biol 19(10):6621-31 |
SGD |
| AHC2/YCR082W | IPI: Inferred from Physical Interaction with SGD:NGG1, SGD:AHC1, SGD:GCN5, SGD:ADA2, SGD:SGF29 Assigned on 2011-07-28 |
manually curated | Lee KK, et al. (2011) Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes. Mol Syst Biol 7():503 |
SGD |
| ARD1/YHR013C | IMP: Inferred from Mutant Phenotype Assigned on 2007-08-03 |
manually curated | Jiang L, et al. (2007) Global assessment of combinatorial post-translational modification of core histones in yeast using contemporary mass spectrometry. LYS4 trimethylation correlates with degree of acetylation on the same H3 tail. J Biol Chem 282(38):27923-34 |
SGD |
| ARP4/YJL081C | IDA: Inferred from Direct Assay Assigned on 2002-09-18 |
manually curated | Galarneau L, et al. (2000) Multiple links between the NuA4 histone acetyltransferase complex and epigenetic control of transcription. Mol Cell 5(6):927-37 |
SGD |
| ASF1/YJL115W | IMP: Inferred from Mutant Phenotype Assigned on 2006-09-21 |
manually curated | Recht J, et al. (2006) Histone chaperone Asf1 is required for histone H3 lysine 56 acetylation, a modification associated with S phase in mitosis and meiosis. Proc Natl Acad Sci U S A 103(18):6988-93 |
SGD |
| EAF3/YPR023C | IDA: Inferred from Direct Assay Assigned on 2002-09-18 |
manually curated | Eisen A, et al. (2001) The yeast NuA4 and Drosophila MSL complexes contain homologous subunits important for transcription regulation. J Biol Chem 276(5):3484-91 |
SGD |
| EAF6/YJR082C | IPI: Inferred from Physical Interaction with SGD:YNG1 Assigned on 2007-03-27 |
manually curated | Taverna SD, et al. (2006) Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs. Mol Cell 24(5):785-96 |
SGD |
| EAF7/YNL136W | IPI: Inferred from Physical Interaction with SGD:EAF7 Assigned on 2004-09-22 |
manually curated | Krogan NJ, et al. (2004) Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4. Proc Natl Acad Sci U S A 101(37):13513-8 |
SGD |
| ELP3/YPL086C | IEA: Inferred from Electronic Annotation with IUBMB:2.3.1.48 Last Updated 2013-03-02 |
computational | GOA curators and MGI curators (2001) Gene Ontology annotation based on Enzyme Commission mapping. |
GOC |
| EPL1/YFL024C | IDA: Inferred from Direct Assay Assigned on 2002-09-18 |
manually curated | Galarneau L, et al. (2000) Multiple links between the NuA4 histone acetyltransferase complex and epigenetic control of transcription. Mol Cell 5(6):927-37 |
SGD |
| ESA1/YOR244W | IDA: Inferred from Direct Assay Assigned on 2007-03-30 |
manually curated | Allard S, et al. (1999) NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. EMBO J 18(18):5108-19 |
SGD |
| IDA: Inferred from Direct Assay Assigned on 2002-07-31 |
manually curated | Clarke AS, et al. (1999) Esa1p is an essential histone acetyltransferase required for cell cycle progression. Mol Cell Biol 19(4):2515-26 |
SGD | |
| GCN5/YGR252W | IMP: Inferred from Mutant Phenotype Assigned on 2007-01-08 |
manually curated | Ruiz-Garcia AB, et al. (1997) Gcn5p is involved in the acetylation of histone H3 in nucleosomes. FEBS Lett 403(2):186-90 |
SGD |
| IGI: Inferred from Genetic Interaction with SGD:RTT109, SGD:ASF1, SGD:VPS75, IMP: Inferred from Mutant Phenotype Assigned on 2008-08-27 |
manually curated | Fillingham J, et al. (2008) Chaperone control of the activity and specificity of the histone H3 acetyltransferase Rtt109. Mol Cell Biol 28(13):4342-53 |
SGD | |
| IDA: Inferred from Direct Assay Assigned on 2009-09-03 |
manually curated | Grant PA, et al. (1998) A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation. Cell 94(1):45-53 |
SGD | |
| HAT1/YPL001W | IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2007-02-16 |
manually curated | Parthun MR, et al. (1996) The major cytoplasmic histone acetyltransferase in yeast: links to chromatin replication and histone metabolism. Cell 87(1):85-94 |
SGD |
| IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2007-02-16 |
manually curated | Kleff S, et al. (1995) Identification of a gene encoding a yeast histone H4 acetyltransferase. J Biol Chem 270(42):24674-7 |
SGD | |
| IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2007-02-16 |
manually curated | Ruiz-Garcia AB, et al. (1998) HAT1 and HAT2 proteins are components of a yeast nuclear histone acetyltransferase enzyme specific for free histone H4. J Biol Chem 273(20):12599-605 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:IPR013523, EBI:IPR017380 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| HAT2/YEL056W | IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2007-02-16 |
manually curated | Parthun MR, et al. (1996) The major cytoplasmic histone acetyltransferase in yeast: links to chromatin replication and histone metabolism. Cell 87(1):85-94 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2007-02-16 |
manually curated | Ruiz-Garcia AB, et al. (1998) HAT1 and HAT2 proteins are components of a yeast nuclear histone acetyltransferase enzyme specific for free histone H4. J Biol Chem 273(20):12599-605 |
SGD | |
| HFI1/YPL254W | IDA: Inferred from Direct Assay Assigned on 2009-09-03 |
manually curated | Grant PA, et al. (1998) A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation. Cell 94(1):45-53 |
SGD |
| HIF1/YLL022C | IDA: Inferred from Direct Assay, IPI: Inferred from Physical Interaction with SGD:HAT1 Assigned on 2007-02-16 |
manually curated | Poveda A, et al. (2004) Hif1 is a component of yeast histone acetyltransferase B, a complex mainly localized in the nucleus. J Biol Chem 279(16):16033-43 |
SGD |
| HPA2/YPR193C | ISS: Inferred from Sequence or structural Similarity with SGD:HAT1 Assigned on 2010-08-10 |
manually curated | Angus-Hill ML, et al. (1999) Crystal structure of the histone acetyltransferase Hpa2: A tetrameric member of the Gcn5-related N-acetyltransferase superfamily. J Mol Biol 294(5):1311-25 |
SGD |
| NAT4/YMR069W | IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2006-10-27 |
manually curated | Song OK, et al. (2003) An Nalpha-acetyltransferase responsible for acetylation of the N-terminal residues of histones H4 and H2A. J Biol Chem 278(40):38109-12 |
SGD |
| NGG1/YDR176W | IDA: Inferred from Direct Assay Assigned on 2009-09-03 |
manually curated | Grant PA, et al. (1998) A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation. Cell 94(1):45-53 |
SGD |
| NTO1/YPR031W | IPI: Inferred from Physical Interaction with SGD:YNG1 Assigned on 2007-03-27 |
manually curated | Taverna SD, et al. (2006) Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs. Mol Cell 24(5):785-96 |
SGD |
| RTT109/YLL002W | IMP: Inferred from Mutant Phenotype Assigned on 2007-02-07 |
manually curated | Schneider J, et al. (2006) Rtt109 is required for proper H3K56 acetylation: a chromatin mark associated with the elongating RNA polymerase II. J Biol Chem 281(49):37270-4 |
SGD |
| IGI: Inferred from Genetic Interaction with SGD:HST4, SGD:HST3, IMP: Inferred from Mutant Phenotype Assigned on 2007-02-07 |
manually curated | Driscoll R, et al. (2007) Yeast Rtt109 promotes genome stability by acetylating histone H3 on lysine 56. Science 315(5812):649-52 |
SGD | |
| IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2007-02-07 |
manually curated | Han J, et al. (2007) Rtt109 acetylates histone H3 lysine 56 and functions in DNA replication. Science 315(5812):653-5 |
SGD | |
| IGI: Inferred from Genetic Interaction with SGD:GCN5, IMP: Inferred from Mutant Phenotype Assigned on 2008-08-27 |
manually curated | Fillingham J, et al. (2008) Chaperone control of the activity and specificity of the histone H3 acetyltransferase Rtt109. Mol Cell Biol 28(13):4342-53 |
SGD | |
| SAS2/YMR127C | IMP: Inferred from Mutant Phenotype Assigned on 2008-08-26 |
manually curated | Altaf M, et al. (2007) Interplay of chromatin modifiers on a short basic patch of histone H4 tail defines the boundary of telomeric heterochromatin. Mol Cell 28(6):1002-14 |
SGD |
| SAS3/YBL052C | IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype Assigned on 2007-03-29 |
manually curated | John S, et al. (2000) The something about silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAF(II)30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)-FACT complex. Genes Dev 14(10):1196-208 |
SGD |
| SGF73/YGL066W | IPI: Inferred from Physical Interaction Assigned on 2002-12-16 |
manually curated | Sanders SL, et al. (2002) Proteomics of the eukaryotic transcription machinery: identification of proteins associated with components of yeast TFIID by multidimensional mass spectrometry. Mol Cell Biol 22(13):4723-38 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2006-04-14 |
manually curated | McMahon SJ, et al. (2005) Polyglutamine-expanded spinocerebellar ataxia-7 protein disrupts normal SAGA and SLIK histone acetyltransferase activity. Proc Natl Acad Sci U S A 102(24):8478-82 |
SGD | |
| SPT10/YJL127C | IMP: Inferred from Mutant Phenotype Assigned on 2013-03-19 |
manually curated | Shen CH, et al. (2002) Targeted histone acetylation at the yeast CUP1 promoter requires the transcriptional activator, the TATA boxes, and the putative histone acetylase encoded by SPT10. Mol Cell Biol 22(18):6406-16 |
SGD |
| SPT20/YOL148C | IDA: Inferred from Direct Assay Assigned on 2009-09-03 |
manually curated | Grant PA, et al. (1998) A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation. Cell 94(1):45-53 |
SGD |
| SPT3/YDR392W | IDA: Inferred from Direct Assay Assigned on 2009-09-03 |
manually curated | Grant PA, et al. (1998) A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation. Cell 94(1):45-53 |
SGD |
