GO term: integral to membrane 
Ontology: Cellular Component (GO:0016021)
Definition: Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.
Synonyms: transmembrane
View Ontology:
(graph) | 
(text)
Definition: Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.
Synonyms: transmembrane
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
integral to membrane (1601 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | integral to membrane | 98 |
| High-throughput (download data) | integral to membrane | 842 |
| Computational (download data) | integral to membrane | 1440 |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
integral to membrane or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| integral to membrane 1601 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| AVT2/YEL064C | ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AVT3/YKL146W | ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AVT4/YNL101W | ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AVT5/YBL089W | ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AVT6/YER119C | ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AVT7/YIL088C | ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AXL2/YIL140W | IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| AYR1/YIL124W | ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD |
| AZR1/YGR224W | ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR011701 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| BAP2/YBR068C | ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR004840, EBI:IPR004762 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| BAP3/YDR046C | ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR004840, EBI:IPR004762 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| BCS1/YDR375C | IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| BET1/YIL004C | IDA: Inferred from Direct Assay Assigned on 2010-06-29 |
manually curated | Newman AP, et al. (1992) Bos1p, a membrane protein required for ER to Golgi transport in yeast, co-purifies with the carrier vesicles and with Bet1p and the ER membrane. EMBO J 11(10):3609-17 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| BI2/Q0110 | IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| BI3/Q0115 | IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| BIG1/YHR101C | IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| BIO5/YNR056C | ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| BLM10/YFL007W | ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD |
| BOR1/YNL275W | ISM: Inferred from Sequence Model Assigned on 2011-07-20 |
manually curated | Zhao R and Reithmeier RA (2001) Expression and characterization of the anion transporter homologue YNL275w in Saccharomyces cerevisiae. Am J Physiol Cell Physiol 281(1):C33-45 |
SGD |
| ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:IPR011531 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| BOS1/YLR078C | IDA: Inferred from Direct Assay Assigned on 2010-06-29 |
manually curated | Newman AP, et al. (1992) Bos1p, a membrane protein required for ER to Golgi transport in yeast, co-purifies with the carrier vesicles and with Bet1p and the ER membrane. EMBO J 11(10):3609-17 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| BPT1/YLL015W | ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR001140, EBI:IPR011527 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| BRE4/YDL231C | ISS: Inferred from Sequence or structural Similarity Assigned on 2001-10-18 |
manually curated | Muren E, et al. (2001) Identification of yeast deletion strains that are hypersensitive to brefeldin A or monensin, two drugs that affect intracellular transport. Yeast 18(2):163-72 |
SGD |
| ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| BRL1/YHR036W | IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| BRR6/YGL247W | IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| BSC2/YDR275W | IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| BSC6/YOL137W | ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR011701 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| BSD2/YBR290W | ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| BST1/YFL025C | ISS: Inferred from Sequence or structural Similarity Assigned on 2001-06-26 |
manually curated | Elrod-Erickson MJ and Kaiser CA (1996) Genes that control the fidelity of endoplasmic reticulum to Golgi transport identified as suppressors of vesicle budding mutations. Mol Biol Cell 7(7):1043-58 |
SGD |
| ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| BUD26/YDR241W | IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| BUD8/YLR353W | IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
