Ontology: Cellular Component (GO:0016021)

Definition: Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

Synonyms: transmembrane

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term integral to membrane (1601 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	integral to membrane	98
High-throughput (download data)	integral to membrane	842
Computational (download data)	integral to membrane	1440

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term integral to membrane or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

integral to membrane      1601 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
FLC2/YAL053W	ISM: Inferred from Sequence Model Assigned on 2011-05-31	high-throughput	De Hertogh B, et al.  (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FLC3/YGL139W	ISS: Inferred from Sequence or structural Similarity Assigned on 2003-04-10	manually curated	Voet M, et al.  (1997) The sequence of a nearly unclonable 22.8 kb segment on the left arm chromosome VII from Saccharomyces cerevisiae reveals ARO2, RPL9A, TIP1, MRF1 genes and six new open reading frames. Yeast 13(2):177-82	SGD
	ISM: Inferred from Sequence Model Assigned on 2011-05-31	high-throughput	De Hertogh B, et al.  (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FLD1/YLR404W	ISM: Inferred from Sequence Model Assigned on 2009-08-26	manually curated	Kim H, et al.  (2003) Topology models for 37 Saccharomyces cerevisiae membrane proteins based on C-terminal reporter fusions and predictions. J Biol Chem 278(12):10208-13	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FLR1/YBR008C	ISM: Inferred from Sequence Model Assigned on 2011-05-31	high-throughput	De Hertogh B, et al.  (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR004734, EBI:IPR011701 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FLX1/YIL134W	ISM: Inferred from Sequence Model Assigned on 2011-05-31	high-throughput	De Hertogh B, et al.  (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FMP10/YER182W	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FMP25/YLR077W	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FMP30/YPL103C	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FMP32/YFL046W	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FMP33/YJL161W	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FMP37/YGL080W	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FMP43/YGR243W	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FMP45/YDL222C	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-06-12	manually curated	Sivadon P, et al.  (1997) Cloning of the multicopy suppressor gene SUR7: evidence for a functional relationship between the yeast actin-binding protein Rvs167 and a putative membranous protein. Yeast 13(8):747-61	SGD
	ISM: Inferred from Sequence Model Assigned on 2011-05-31	high-throughput	De Hertogh B, et al.  (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FPS1/YLL043W	ISM: Inferred from Sequence Model Assigned on 2011-05-31	high-throughput	De Hertogh B, et al.  (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FRE1/YLR214W	ISM: Inferred from Sequence Model Assigned on 2011-05-31	high-throughput	De Hertogh B, et al.  (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FRE2/YKL220C	ISM: Inferred from Sequence Model Assigned on 2011-05-31	high-throughput	De Hertogh B, et al.  (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FRE3/YOR381W	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-03-14	manually curated	Martins LJ, et al.  (1998) Metalloregulation of FRE1 and FRE2 homologs in Saccharomyces cerevisiae. J Biol Chem 273(37):23716-21	SGD
	ISM: Inferred from Sequence Model Assigned on 2011-05-31	high-throughput	De Hertogh B, et al.  (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FRE4/YNR060W	ISM: Inferred from Sequence Model Assigned on 2011-05-31	high-throughput	De Hertogh B, et al.  (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FRE5/YOR384W	ISM: Inferred from Sequence Model Assigned on 2011-05-31	high-throughput	De Hertogh B, et al.  (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FRE6/YLL051C	ISM: Inferred from Sequence Model Assigned on 2011-05-31	high-throughput	De Hertogh B, et al.  (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FRE7/YOL152W	ISM: Inferred from Sequence Model Assigned on 2011-05-31	high-throughput	De Hertogh B, et al.  (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FRE8/YLR047C	ISM: Inferred from Sequence Model Assigned on 2011-05-31	high-throughput	De Hertogh B, et al.  (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FRT1/YOR324C	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FRT2/YAL028W	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FSF1/YOR271C	ISM: Inferred from Sequence Model Assigned on 2011-05-31	high-throughput	De Hertogh B, et al.  (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FTH1/YBR207W	ISM: Inferred from Sequence Model Assigned on 2011-05-31	high-throughput	De Hertogh B, et al.  (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FTR1/YER145C	ISM: Inferred from Sequence Model Assigned on 2011-05-31	high-throughput	De Hertogh B, et al.  (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FUI1/YBL042C	ISM: Inferred from Sequence Model Assigned on 2011-05-31	high-throughput	De Hertogh B, et al.  (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70	SGD
	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FUN14/YAL008W	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
FUN26/YAL022C	ISM: Inferred from Sequence Model Assigned on 2011-05-31	high-throughput	De Hertogh B, et al.  (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR002259 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02	computational	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB

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