GO term: integral to membrane 
Ontology: Cellular Component (GO:0016021)
Definition: Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.
Synonyms: transmembrane
View Ontology:
(graph) | 
(text)
Definition: Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.
Synonyms: transmembrane
View Ontology:
(graph) | (text)
This table lists the methods used to annotate genes either directly to the term
integral to membrane (1601 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | integral to membrane | 98 |
| High-throughput (download data) | integral to membrane | 842 |
| Computational (download data) | integral to membrane | 1440 |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
integral to membrane or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| integral to membrane 1601 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| AAC1/YMR056C | ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AAC3/YBR085W | ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| ACS1/YAL054C | ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD |
| ADP1/YCR011C | ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| ADY2/YCR010C | ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AFG3/YER017C | IEA: Inferred from Electronic Annotation with EBI:IPR011546 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AGC1/YPR021C | ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AGP1/YCL025C | ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR004762, EBI:IPR004840 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AGP2/YBR132C | ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR004840 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AGP3/YFL055W | ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:IPR004840 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AI2/Q0055 | IEA: Inferred from Electronic Annotation with EBI:IPR000883 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| AI3/Q0060 | IEA: Inferred from Electronic Annotation with EBI:IPR000883 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AI4/Q0065 | IEA: Inferred from Electronic Annotation with EBI:IPR000883 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| AI5_ALPHA/Q0070 | IEA: Inferred from Electronic Annotation with EBI:IPR000883 Last Updated 2013-03-02 |
computational | DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms. |
InterPro |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AIF1/YNR074C | IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| AIM11/YER093C-A | IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| AIM14/YGL160W | ISM: Inferred from Sequence Model Assigned on 2011-05-27 |
high-throughput | Georgatsou E and Alexandraki D (1999) Regulated expression of the Saccharomyces cerevisiae Fre1p/Fre2p Fe/Cu reductase related genes. Yeast 15(7):573-84 |
SGD |
| ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AIM19/YIL087C | IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| AIM20/YIL158W | IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| AIM26/YKL037W | ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AIM33/YML087C | IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| AIM34/YMR003W | IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| AIM36/YMR157C | IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| AIM37/YNL100W | IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| AIM39/YOL053W | IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| AIM43/YPL099C | IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| AIM5/YBR262C | IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB |
| AKR1/YDR264C | ISM: Inferred from Sequence Model Assigned on 2011-04-22 |
high-throughput | Politis EG, et al. (2005) Transmembrane topology of the protein palmitoyl transferase Akr1. J Biol Chem 280(11):10156-63 |
SGD |
| ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD | |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| AKR2/YOR034C | ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
| ALE1/YOR175C | ISM: Inferred from Sequence Model Assigned on 2011-05-31 |
high-throughput | De Hertogh B, et al. (2002) Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae. Funct Integr Genomics 2(4-5):154-70 |
SGD |
| IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last Updated 2013-03-02 |
computational | UniProt-GOA (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries. |
UniProtKB | |
