Ontology: Molecular Function (GO:0015662)

Definition: Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate.

Synonyms: zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity; P-type ATPase activity

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism (7 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism	7
High-throughput	none	none
Computational	none	none

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism      7 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
DNF1/YER166W	ISS: Inferred from Sequence or structural Similarity with SGD:PMR1, SGD:ENA1 Assigned on 2006-10-12	manually curated	Catty P, et al.  (1997) The complete inventory of the yeast Saccharomyces cerevisiae P-type transport ATPases. FEBS Lett 409(3):325-32	SGD
ENA2/YDR039C	IGI: Inferred from Genetic Interaction with SGD:ENA1 Assigned on 2006-10-17	manually curated	Haro R, et al.  (1991) A novel P-type ATPase from yeast involved in sodium transport. FEBS Lett 291(2):189-91	SGD
	ISS: Inferred from Sequence or structural Similarity with SGD:ENA1 Assigned on 2006-10-20	manually curated	Garciadeblas B, et al.  (1993) Differential expression of two genes encoding isoforms of the ATPase involved in sodium efflux in Saccharomyces cerevisiae. Mol Gen Genet 236(2-3):363-8	SGD
ENA5/YDR038C	ISS: Inferred from Sequence or structural Similarity with SGD:ENA1 Assigned on 2006-10-13	manually curated	Wieland J, et al.  (1995) The PMR2 gene cluster encodes functionally distinct isoforms of a putative Na+ pump in the yeast plasma membrane. EMBO J 14(16):3870-82	SGD
ENA6	IMP: Inferred from Mutant Phenotype, ISA: Inferred from Sequence Alignment with SGD:ENA1, SGD:ENA2, SGD:ENA5 Assigned on 2009-06-23	manually curated	Daran-Lapujade P, et al.  (2009) An atypical PMR2 locus is responsible for hypersensitivity to sodium and lithium cations in the laboratory strain Saccharomyces cerevisiae CEN.PK113-7D. FEMS Yeast Res 9(5):789-92	SGD
NEO1/YIL048W	ISS: Inferred from Sequence or structural Similarity with SGD:PMR1, SGD:ENA1 Assigned on 2007-03-01	manually curated	Catty P, et al.  (1997) The complete inventory of the yeast Saccharomyces cerevisiae P-type transport ATPases. FEBS Lett 409(3):325-32	SGD
PCA1/YBR295W	ISS: Inferred from Sequence or structural Similarity with EBI:Q47839 Assigned on 2006-10-12	manually curated	Rad MR, et al.  (1994) A putative P-type Cu(2+)-transporting ATPase gene on chromosome II of Saccharomyces cerevisiae. Yeast 10(9):1217-25	SGD
SPF1/YEL031W	IDA: Inferred from Direct Assay Assigned on 2002-10-03	manually curated	Cronin SR, et al.  (2002) Cod1p/Spf1p is a P-type ATPase involved in ER function and Ca2+ homeostasis. J Cell Biol 157(6):1017-28	SGD

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