GO term: ubiquitin ligase complex

Ontology: Cellular Component (GO:0000151)

Definition: A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex.

Annotation Summary

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This table lists the methods used to annotate genes either directly to the term ubiquitin ligase complex (14 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	ubiquitin ligase complex	10
High-throughput	none	none
Computational (download data)	ubiquitin ligase complex	4

Links to Additional Annotations:

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Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Genes Annotated with this Term

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Annotation details for genes that have been directly annotated to the term ubiquitin ligase complex or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

ubiquitin ligase complex 14 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
BUL1/YMR275C	TAS: Traceable Author Statement Assigned on 2004-11-30	manually curated	Helliwell SB, et al. (2001) Components of a ubiquitin ligase complex specify polyubiquitination and intracellular trafficking of the general amino acid permease. J Cell Biol 153(4):649-62	SGD
BUL1/YMR275C	IDA: Inferred from Direct Assay Assigned on 2005-10-09	manually curated	Yashiroda H, et al. (1998) The PY-motif of Bul1 protein is essential for growth of Saccharomyces cerevisiae under various stress conditions. Gene 225(1-2):39-46	SGD
BUL2/YML111W	IMP: Inferred from Mutant Phenotype Assigned on 2005-10-10	manually curated	Helliwell SB, et al. (2001) Components of a ubiquitin ligase complex specify polyubiquitination and intracellular trafficking of the general amino acid permease. J Cell Biol 153(4):649-62	SGD
MFB1/YDR219C	ISS: Inferred from Sequence or structural Similarity Assigned on 2003-02-05	manually curated	Patton EE, et al. (1998) Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis. Trends Genet 14(6):236-43	SGD
PRP19/YLL036C	IEA: Inferred from Electronic Annotation with EBI:IPR003613 Last Updated 2009-11-20	computational	DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms.	UniProtKB
RCY1/YJL204C	RCA: Reviewed Computational Analysis Assigned on 2009-09-03	computational	Tian W, et al. (2008) Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1:S7	YeastFunc
RSP5/YER125W	IPI: Inferred from Physical Interaction with SGD:BUL1 Assigned on 2008-10-13	manually curated	Yashiroda H, et al. (1998) The PY-motif of Bul1 protein is essential for growth of Saccharomyces cerevisiae under various stress conditions. Gene 225(1-2):39-46	SGD
RTT101/YJL047C	RCA: Reviewed Computational Analysis Assigned on 2009-09-03	computational	Tian W, et al. (2008) Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function. Genome Biol 9 Suppl 1:S7	YeastFunc
SGT1/YOR057W	IDA: Inferred from Direct Assay Assigned on 2002-06-30	manually curated	Kitagawa K, et al. (1999) SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex. Mol Cell 4(1):21-33	SGD
SLX5/YDL013W	IDA: Inferred from Direct Assay Assigned on 2007-09-21	manually curated	Xie Y, et al. (2007) The Yeast Hex3{middle dot}Slx8 Heterodimer Is a Ubiquitin Ligase Stimulated by Substrate Sumoylation. J Biol Chem 282(47):34176-84	SGD
SLX8/YER116C	IDA: Inferred from Direct Assay Assigned on 2007-09-21	manually curated	Xie Y, et al. (2007) The Yeast Hex3{middle dot}Slx8 Heterodimer Is a Ubiquitin Ligase Stimulated by Substrate Sumoylation. J Biol Chem 282(47):34176-84	SGD
UFD2/YDL190C	IEA: Inferred from Electronic Annotation with EBI:IPR003613, EBI:IPR019474 Last Updated 2009-11-20	computational	DDB, et al. (2001) Gene Ontology annotation through association of InterPro records with GO terms.	UniProtKB
YDR306C	ISS: Inferred from Sequence or structural Similarity Assigned on 2003-02-05	manually curated	Patton EE, et al. (1998) Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis. Trends Genet 14(6):236-43	SGD
YLR224W	ISS: Inferred from Sequence or structural Similarity with SGD:MET30, SGD:CDC4, SGD:GRR1 Assigned on 2006-04-10	manually curated	Patton EE, et al. (1998) Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis. Trends Genet 14(6):236-43	SGD
YLR224W	IPI: Inferred from Physical Interaction with SGD:SKP1, SGD:CDC53, SGD:HRT1, SGD:UBC4 Assigned on 2006-04-10	manually curated	Kus BM, et al. (2004) Functional interaction of 13 yeast SCF complexes with a set of yeast E2 enzymes in vitro. Proteins 54(3):455-67	SGD
YNL311C	ISS: Inferred from Sequence or structural Similarity Assigned on 2003-02-05	manually curated	Patton EE, et al. (1998) Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis. Trends Genet 14(6):236-43	SGD

Graphical Display

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This diagram shows the local area of the Gene Ontology and the numbers of yeast genes annotated to each term in the diagram. Within the diagram, click on the blue arrow to navigate up the tree and click on a GO term name to go to its GO term page.

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