Ontology: Biological Process (GO:0000132)

Definition: A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.

Synonyms: establishment of spindle orientation during mitosis; mitotic spindle orientation; orienting of mitotic spindle; establishment of spindle orientation involved in mitotic cell cycle

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term establishment of mitotic spindle orientation (12 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	establishment of mitotic spindle orientation	12
High-throughput	none	none
Computational	none	none

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term establishment of mitotic spindle orientation or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

establishment of mitotic spindle orientation      12 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ACT1/YFL039C	TAS: Traceable Author Statement Assigned on 2004-01-28	manually curated	Pruyne D and Bretscher A  (2000) Polarization of cell growth in yeast. J Cell Sci 113 ( Pt 4):571-85	SGD
ARP1/YHR129C	IMP: Inferred from Mutant Phenotype Assigned on 2005-05-12	manually curated	Muhua L, et al.  (1994) A yeast actin-related protein homologous to that in vertebrate dynactin complex is important for spindle orientation and nuclear migration. Cell 78(4):669-79	SGD
BNI1/YNL271C	IMP: Inferred from Mutant Phenotype Assigned on 2004-01-28	manually curated	Lee L, et al.  (1999) Control of mitotic spindle position by the Saccharomyces cerevisiae formin Bni1p. J Cell Biol 144(5):947-61	SGD
CIK1/YMR198W	TAS: Traceable Author Statement Assigned on 2004-01-28	manually curated	Cottingham FR, et al.  (1999) Novel roles for saccharomyces cerevisiae mitotic spindle motors. J Cell Biol 147(2):335-50	SGD
DMA1/YHR115C	IGI: Inferred from Genetic Interaction with SGD:DMA2 Assigned on 2004-09-21	manually curated	Fraschini R, et al.  (2004) Functional characterization of Dma1 and Dma2, the budding yeast homologues of Schizosaccharomyces pombe Dma1 and human Chfr. Mol Biol Cell 15(8):3796-810	SGD
	IGI: Inferred from Genetic Interaction with SGD:DMA2 Assigned on 2012-12-12	manually curated	Merlini L, et al.  (2012) Budding yeast dma proteins control septin dynamics and the spindle position checkpoint by promoting the recruitment of the elm1 kinase to the bud neck. PLoS Genet 8(4):e1002670	SGD
DMA2/YNL116W	IGI: Inferred from Genetic Interaction with SGD:DMA1 Assigned on 2004-09-21	manually curated	Fraschini R, et al.  (2004) Functional characterization of Dma1 and Dma2, the budding yeast homologues of Schizosaccharomyces pombe Dma1 and human Chfr. Mol Biol Cell 15(8):3796-810	SGD
	IGI: Inferred from Genetic Interaction with SGD:DMA1 Assigned on 2012-12-12	manually curated	Merlini L, et al.  (2012) Budding yeast dma proteins control septin dynamics and the spindle position checkpoint by promoting the recruitment of the elm1 kinase to the bud neck. PLoS Genet 8(4):e1002670	SGD
DYN1/YKR054C	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2004-01-28	manually curated	Cottingham FR and Hoyt MA  (1997) Mitotic spindle positioning in Saccharomyces cerevisiae is accomplished by antagonistically acting microtubule motor proteins. J Cell Biol 138(5):1041-53	SGD
JNM1/YMR294W	IMP: Inferred from Mutant Phenotype Assigned on 2010-10-21	manually curated	McMillan JN and Tatchell K  (1994) The JNM1 gene in the yeast Saccharomyces cerevisiae is required for nuclear migration and spindle orientation during the mitotic cell cycle. J Cell Biol 125(1):143-58	SGD
KIP3/YGL216W	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2004-01-28	manually curated	Cottingham FR and Hoyt MA  (1997) Mitotic spindle positioning in Saccharomyces cerevisiae is accomplished by antagonistically acting microtubule motor proteins. J Cell Biol 138(5):1041-53	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2009-02-27	manually curated	Gupta ML Jr, et al.  (2006) Plus end-specific depolymerase activity of Kip3, a kinesin-8 protein, explains its role in positioning the yeast mitotic spindle. Nat Cell Biol 8(9):913-23	SGD
LDB18/YLL049W	IMP: Inferred from Mutant Phenotype Assigned on 2009-05-21	manually curated	Amaro IA, et al.  (2008) The Saccharomyces cerevisiae Homolog of p24 Is Essential for Maintaining the Association of p150Glued With the Dynactin Complex. Genetics 178(2):703-9	SGD
MYO2/YOR326W	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:KAR9 Assigned on 2006-10-19	manually curated	Yin H, et al.  (2000) Myosin V orientates the mitotic spindle in yeast. Nature 406(6799):1013-5	SGD
NIP100/YPL174C	IMP: Inferred from Mutant Phenotype Assigned on 2005-05-12	manually curated	Kahana JA, et al.  (1998) The yeast dynactin complex is involved in partitioning the mitotic spindle between mother and daughter cells during anaphase B. Mol Biol Cell 9(7):1741-56	SGD

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