GO term: chronological cell aging 
Ontology: Biological Process (GO:0001300)
Definition: The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state.
Synonyms: chronological cell ageing
Definition: The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state.
Synonyms: chronological cell ageing
This table lists the methods used to annotate genes either directly to the term
chronological cell aging (15 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | chronological cell aging | 15 |
| High-throughput | none | none |
| Computational | none | none |
Links to Additional Annotations:
Annotation details for genes that have been directly annotated to the term
chronological cell aging or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| chronological cell aging 15 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| AAT1/YKL106W | IMP: Inferred from Mutant Phenotype Assigned on 2008-09-05 |
manually curated | Easlon E, et al. (2008) The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast. Genes Dev 22(7):931-44 |
SGD |
| ACT1/YFL039C | IMP: Inferred from Mutant Phenotype Assigned on 2004-10-01 |
manually curated | Gourlay CW, et al. (2004) A role for the actin cytoskeleton in cell death and aging in yeast. J Cell Biol 164(6):803-9 |
SGD |
| DNM1/YLL001W | IMP: Inferred from Mutant Phenotype Assigned on 2008-09-23 |
manually curated | Palermo V, et al. (2007) Apoptosis and aging in mitochondrial morphology mutants of S. cerevisiae. Folia Microbiol (Praha) 52(5):479-83 |
SGD |
| FIS1/YIL065C | IMP: Inferred from Mutant Phenotype Assigned on 2008-09-23 |
manually curated | Palermo V, et al. (2007) Apoptosis and aging in mitochondrial morphology mutants of S. cerevisiae. Folia Microbiol (Praha) 52(5):479-83 |
SGD |
| GTS1/YGL181W | IMP: Inferred from Mutant Phenotype Assigned on 2003-08-14 |
manually curated | Yaguchi S, et al. (1996) The pleiotropic effect of the GTS1 gene product on heat tolerance, sporulation and the life span of Saccharomyces cerevisiae. Biochem Biophys Res Commun 218(1):234-7 |
SGD |
| HST2/YPL015C | IGI: Inferred from Genetic Interaction with SGD:SIR2, SGD:FOB1, IMP: Inferred from Mutant Phenotype Assigned on 2007-02-15 |
manually curated | Lamming DW, et al. (2005) HST2 mediates SIR2-independent life-span extension by calorie restriction. Science 309(5742):1861-4 |
SGD |
| MDH1/YKL085W | IMP: Inferred from Mutant Phenotype Assigned on 2008-09-05 |
manually curated | Easlon E, et al. (2008) The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast. Genes Dev 22(7):931-44 |
SGD |
| MDM30/YLR368W | IMP: Inferred from Mutant Phenotype Assigned on 2008-09-23 |
manually curated | Palermo V, et al. (2007) Apoptosis and aging in mitochondrial morphology mutants of S. cerevisiae. Folia Microbiol (Praha) 52(5):479-83 |
SGD |
| NDE1/YMR145C | IMP: Inferred from Mutant Phenotype Assigned on 2006-03-02 |
manually curated | Li W, et al. (2006) Yeast AMID homologue Ndi1p displays respiration-restricted apoptotic activity and is involved in chronological aging. Mol Biol Cell 17(4):1802-11 |
SGD |
| NDI1/YML120C | IMP: Inferred from Mutant Phenotype Assigned on 2006-03-02 |
manually curated | Li W, et al. (2006) Yeast AMID homologue Ndi1p displays respiration-restricted apoptotic activity and is involved in chronological aging. Mol Biol Cell 17(4):1802-11 |
SGD |
| PGA3/YML125C | IMP: Inferred from Mutant Phenotype Assigned on 2009-03-03 |
manually curated | Jimenez-Hidalgo M, et al. (2009) NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast. Aging Cell 8(2):140-51 |
SGD |
| SCP1/YOR367W | IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2004-10-01 |
manually curated | Gourlay CW, et al. (2004) A role for the actin cytoskeleton in cell death and aging in yeast. J Cell Biol 164(6):803-9 |
SGD |
| SIR2/YDL042C | IMP: Inferred from Mutant Phenotype Assigned on 2005-12-19 |
manually curated | Fabrizio P, et al. (2005) Sir2 blocks extreme life-span extension. Cell 123(4):655-67 |
SGD |
| SSD1/YDR293C | IMP: Inferred from Mutant Phenotype Assigned on 2009-07-13 |
manually curated | Li L, et al. (2009) Budding yeast SSD1-V regulates transcript levels of many longevity genes and extends chronological life span in purified quiescent cells. Mol Biol Cell 20(17):3851-64 |
SGD |
| YME1/YPR024W | IMP: Inferred from Mutant Phenotype Assigned on 2008-09-23 |
manually curated | Palermo V, et al. (2007) Apoptosis and aging in mitochondrial morphology mutants of S. cerevisiae. Folia Microbiol (Praha) 52(5):479-83 |
SGD |
This diagram shows the local area of the Gene Ontology and the numbers of yeast genes annotated to each term in the diagram. Within the diagram, click on the blue arrow to navigate up the tree and click on a GO term name to go to its GO term page.
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