Ontology: Biological Process (GO:0001300)

Definition: The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state.

Synonyms: chronological cell ageing

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term chronological cell aging (18 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	chronological cell aging	18
High-throughput	none	none
Computational	none	none

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term chronological cell aging or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

chronological cell aging      18 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
AAT1/YKL106W	IMP: Inferred from Mutant Phenotype Assigned on 2008-09-05	manually curated	Easlon E, et al.  (2008) The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast. Genes Dev 22(7):931-44	SGD
ACB1/YGR037C	IMP: Inferred from Mutant Phenotype Assigned on 2011-01-13	manually curated	Fabrizio P, et al.  (2010) Genome-Wide Screen in Saccharomyces cerevisiae Identifies Vacuolar Protein Sorting, Autophagy, Biosynthetic, and tRNA Methylation Genes Involved in Life Span Regulation. PLoS Genet 6(7):e1001024	SGD
ACT1/YFL039C	IMP: Inferred from Mutant Phenotype Assigned on 2004-10-01	manually curated	Gourlay CW, et al.  (2004) A role for the actin cytoskeleton in cell death and aging in yeast. J Cell Biol 164(6):803-9	SGD
ALT1/YLR089C	IMP: Inferred from Mutant Phenotype Assigned on 2013-05-10	manually curated	Yu SL, et al.  (2013) Alanine-Metabolizing Enzyme Alt1 Is Critical in Determining Yeast Life Span, As Revealed by Combined Metabolomic and Genetic Studies. J Proteome Res ()	SGD
CKA2/YOR061W	IMP: Inferred from Mutant Phenotype Assigned on 2011-01-13	manually curated	Fabrizio P, et al.  (2010) Genome-Wide Screen in Saccharomyces cerevisiae Identifies Vacuolar Protein Sorting, Autophagy, Biosynthetic, and tRNA Methylation Genes Involved in Life Span Regulation. PLoS Genet 6(7):e1001024	SGD
DNM1/YLL001W	IMP: Inferred from Mutant Phenotype Assigned on 2008-09-23	manually curated	Palermo V, et al.  (2007) Apoptosis and aging in mitochondrial morphology mutants of S. cerevisiae. Folia Microbiol (Praha) 52(5):479-83	SGD
FIS1/YIL065C	IMP: Inferred from Mutant Phenotype Assigned on 2008-09-23	manually curated	Palermo V, et al.  (2007) Apoptosis and aging in mitochondrial morphology mutants of S. cerevisiae. Folia Microbiol (Praha) 52(5):479-83	SGD
GIS1/YDR096W	IMP: Inferred from Mutant Phenotype Assigned on 2011-07-07	manually curated	Wei M, et al.  (2008) Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9. PLoS Genet 4(1):e13	SGD
HST2/YPL015C	IGI: Inferred from Genetic Interaction with SGD:SIR2, SGD:FOB1, IMP: Inferred from Mutant Phenotype Assigned on 2007-02-15	manually curated	Lamming DW, et al.  (2005) HST2 mediates SIR2-independent life-span extension by calorie restriction. Science 309(5742):1861-4	SGD
MDH1/YKL085W	IMP: Inferred from Mutant Phenotype Assigned on 2008-09-05	manually curated	Easlon E, et al.  (2008) The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast. Genes Dev 22(7):931-44	SGD
MDM30/YLR368W	IMP: Inferred from Mutant Phenotype Assigned on 2008-09-23	manually curated	Palermo V, et al.  (2007) Apoptosis and aging in mitochondrial morphology mutants of S. cerevisiae. Folia Microbiol (Praha) 52(5):479-83	SGD
NDE1/YMR145C	IMP: Inferred from Mutant Phenotype Assigned on 2006-03-02	manually curated	Li W, et al.  (2006) Yeast AMID homologue Ndi1p displays respiration-restricted apoptotic activity and is involved in chronological aging. Mol Biol Cell 17(4):1802-11	SGD
NDI1/YML120C	IMP: Inferred from Mutant Phenotype Assigned on 2006-03-02	manually curated	Li W, et al.  (2006) Yeast AMID homologue Ndi1p displays respiration-restricted apoptotic activity and is involved in chronological aging. Mol Biol Cell 17(4):1802-11	SGD
PGA3/YML125C	IMP: Inferred from Mutant Phenotype Assigned on 2009-03-03	manually curated	Jimenez-Hidalgo M, et al.  (2009) NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast. Aging Cell 8(2):140-51	SGD
SCP1/YOR367W	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2004-10-01	manually curated	Gourlay CW, et al.  (2004) A role for the actin cytoskeleton in cell death and aging in yeast. J Cell Biol 164(6):803-9	SGD
SIR2/YDL042C	IMP: Inferred from Mutant Phenotype Assigned on 2005-12-19	manually curated	Fabrizio P, et al.  (2005) Sir2 blocks extreme life-span extension. Cell 123(4):655-67	SGD
TEC1/YBR083W	IMP: Inferred from Mutant Phenotype Assigned on 2011-09-30	manually curated	Bruckner S, et al.  (2011) The TEA transcription factor Tec1 links TOR and MAPK pathways to coordinate yeast development. Genetics 189(2):479-94	SGD
TRM9/YML014W	IMP: Inferred from Mutant Phenotype Assigned on 2011-01-13	manually curated	Fabrizio P, et al.  (2010) Genome-Wide Screen in Saccharomyces cerevisiae Identifies Vacuolar Protein Sorting, Autophagy, Biosynthetic, and tRNA Methylation Genes Involved in Life Span Regulation. PLoS Genet 6(7):e1001024	SGD

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