Ontology: Cellular Component (GO:0000123)

Definition: A protein complex that possesses histone acetyltransferase activity.

Synonyms: histone acetylase complex

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term histone acetyltransferase complex (9 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	histone acetyltransferase complex	9
High-throughput	none	none
Computational (download data)	histone acetyltransferase complex	1

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term histone acetyltransferase complex or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

histone acetyltransferase complex      9 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ACT1/YFL039C	IDA: Inferred from Direct Assay Assigned on 2002-09-18	manually curated	Galarneau L, et al.  (2000) Multiple links between the NuA4 histone acetyltransferase complex and epigenetic control of transcription. Mol Cell 5(6):927-37	SGD
EAF1/YDR359C	IPI: Inferred from Physical Interaction Assigned on 2004-01-05	manually curated	Nourani A, et al.  (2003) Opposite role of yeast ING family members in p53-dependent transcriptional activation. J Biol Chem 278(21):19171-5	SGD
EAF3/YPR023C	IDA: Inferred from Direct Assay Assigned on 2002-09-18	manually curated	Eisen A, et al.  (2001) The yeast NuA4 and Drosophila MSL complexes contain homologous subunits important for transcription regulation. J Biol Chem 276(5):3484-91	SGD
EAF7/YNL136W	IDA: Inferred from Direct Assay Assigned on 2004-09-22	manually curated	Krogan NJ, et al.  (2004) Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4. Proc Natl Acad Sci U S A 101(37):13513-8	SGD
HAT1/YPL001W	IDA: Inferred from Direct Assay, IPI: Inferred from Physical Interaction with SGD:HAT2 Assigned on 2007-02-16	manually curated	Parthun MR, et al.  (1996) The major cytoplasmic histone acetyltransferase in yeast: links to chromatin replication and histone metabolism. Cell 87(1):85-94	SGD
	IDA: Inferred from Direct Assay Assigned on 2007-02-16	manually curated	Ruiz-Garcia AB, et al.  (1998) HAT1 and HAT2 proteins are components of a yeast nuclear histone acetyltransferase enzyme specific for free histone H4. J Biol Chem 273(20):12599-605	SGD
	IPI: Inferred from Physical Interaction Assigned on 2004-04-27	manually curated	Poveda A, et al.  (2004) Hif1 is a component of yeast histone acetyltransferase B, a complex mainly localized in the nucleus. J Biol Chem 279(16):16033-43	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR013523 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
HAT2/YEL056W	IDA: Inferred from Direct Assay, IPI: Inferred from Physical Interaction with SGD:HAT1 Assigned on 2007-02-16	manually curated	Parthun MR, et al.  (1996) The major cytoplasmic histone acetyltransferase in yeast: links to chromatin replication and histone metabolism. Cell 87(1):85-94	SGD
	IDA: Inferred from Direct Assay Assigned on 2007-02-16	manually curated	Ruiz-Garcia AB, et al.  (1998) HAT1 and HAT2 proteins are components of a yeast nuclear histone acetyltransferase enzyme specific for free histone H4. J Biol Chem 273(20):12599-605	SGD
	IPI: Inferred from Physical Interaction Assigned on 2004-04-27	manually curated	Poveda A, et al.  (2004) Hif1 is a component of yeast histone acetyltransferase B, a complex mainly localized in the nucleus. J Biol Chem 279(16):16033-43	SGD
HIF1/YLL022C	IDA: Inferred from Direct Assay, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:HAT1 Assigned on 2007-02-16	manually curated	Poveda A, et al.  (2004) Hif1 is a component of yeast histone acetyltransferase B, a complex mainly localized in the nucleus. J Biol Chem 279(16):16033-43	SGD
	IDA: Inferred from Direct Assay Assigned on 2007-02-16	manually curated	Ai X and Parthun MR  (2004) The nuclear Hat1p/Hat2p complex: a molecular link between type B histone acetyltransferases and chromatin assembly. Mol Cell 14(2):195-205	SGD
SWC4/YGR002C	IPI: Inferred from Physical Interaction Assigned on 2004-01-05	manually curated	Nourani A, et al.  (2003) Opposite role of yeast ING family members in p53-dependent transcriptional activation. J Biol Chem 278(21):19171-5	SGD
TRA1/YHR099W	IPI: Inferred from Physical Interaction Assigned on 2002-09-18	manually curated	Galarneau L, et al.  (2000) Multiple links between the NuA4 histone acetyltransferase complex and epigenetic control of transcription. Mol Cell 5(6):927-37	SGD

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