GO term: negative regulation of transcription from RNA polymerase II promoter 
Ontology: Biological Process (GO:0000122)
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
Synonyms: down regulation of transcription from RNA polymerase II promoter; down-regulation of transcription from RNA polymerase II promoter; downregulation of transcription from RNA polymerase II promoter; inhibition of transcription from RNA polymerase II promoter; negative regulation of transcription from Pol II promoter; down regulation of global transcription from RNA polymerase II promoter; down-regulation of global transcription from RNA polymerase II promoter; downregulation of global transcription from RNA polymerase II promoter; inhibition of global transcription from RNA polymerase II promoter; negative regulation of global transcription from Pol II promoter; negative regulation of gene-specific transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter, global
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(text)
Definition: Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.
Synonyms: down regulation of transcription from RNA polymerase II promoter; down-regulation of transcription from RNA polymerase II promoter; downregulation of transcription from RNA polymerase II promoter; inhibition of transcription from RNA polymerase II promoter; negative regulation of transcription from Pol II promoter; down regulation of global transcription from RNA polymerase II promoter; down-regulation of global transcription from RNA polymerase II promoter; downregulation of global transcription from RNA polymerase II promoter; inhibition of global transcription from RNA polymerase II promoter; negative regulation of global transcription from Pol II promoter; negative regulation of gene-specific transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter, global
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This table lists the methods used to annotate genes either directly to the term
negative regulation of transcription from RNA polymerase II promoter (82 genes)
or to its variants containing one or more
qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.
Links to Additional Annotations:
| Annotation Method | GO Term | # Yeast Genes Annotated |
|---|---|---|
| Manually curated (download data) | negative regulation of transcription from RNA polymerase II promoter | 82 |
| High-throughput (download data) | negative regulation of transcription from RNA polymerase II promoter | 1 |
| Computational | none | none |
Links to Additional Annotations:
- View
annotations in multiple organisms using
- Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.
Annotation details for genes that have been directly annotated to the term
negative regulation of transcription from RNA polymerase II promoter or its variants containing one or more
qualifiers (NOT, contributes to, or colocalizes with).
| negative regulation of transcription from RNA polymerase II promoter 82 genes directly annotated to this term |
||||
|---|---|---|---|---|
| Locus | Evidence | Annotation Method | Reference | Assigned By |
| ABF1/YKL112W | IMP: Inferred from Mutant Phenotype Assigned on 2005-10-20 |
manually curated | Miyake T, et al. (2004) Genome-wide analysis of ARS (autonomously replicating sequence) binding factor 1 (Abf1p)-mediated transcriptional regulation in Saccharomyces cerevisiae. J Biol Chem 279(33):34865-72 |
SGD |
| ADF1/YCL058W-A | IMP: Inferred from Mutant Phenotype Assigned on 2010-03-10 |
manually curated | Li D, et al. (2010) A de novo originated gene depresses budding yeast mating pathway and is repressed by the protein encoded by its antisense strand. Cell Res 20(4):408-20 |
SGD |
| ARG82/YDR173C | IMP: Inferred from Mutant Phenotype Assigned on 2007-12-19 |
manually curated | El Alami M, et al. (2003) Arg82p is a bifunctional protein whose inositol polyphosphate kinase activity is essential for nitrogen and PHO gene expression but not for Mcm1p chaperoning in yeast. Mol Microbiol 49(2):457-68 |
SGD |
| BUR6/YER159C | IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2002-09-18 |
manually curated | Kim S, et al. (2000) Genetic analysis of the YDR1-BUR6 repressor complex reveals an intricate balance among transcriptional regulatory proteins in yeast. Mol Cell Biol 20(7):2455-65 |
SGD |
| BYE1/YKL005C | IGI: Inferred from Genetic Interaction with SGD:DST1, IMP: Inferred from Mutant Phenotype Assigned on 2011-06-06 |
manually curated | Wu X, et al. (2003) The ESS1 prolyl isomerase and its suppressor BYE1 interact with RNA pol II to inhibit transcription elongation in Saccharomyces cerevisiae. Genetics 165(4):1687-702 |
SGD |
| CBF1/YJR060W | IMP: Inferred from Mutant Phenotype Assigned on 2011-08-22 |
manually curated | Dormer UH, et al. (2000) Cadmium-inducible expression of the yeast GSH1 gene requires a functional sulfur-amino acid regulatory network. J Biol Chem 275(42):32611-6 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2013-05-14 |
manually curated | McIsaac RS, et al. (2012) Perturbation-based analysis and modeling of combinatorial regulation in the yeast sulfur assimilation pathway. Mol Biol Cell 23(15):2993-3007 |
SGD | |
| CDC36/YDL165W | TAS: Traceable Author Statement Assigned on 2001-01-18 |
manually curated | Collart MA and Struhl K (1994) NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization. Genes Dev 8(5):525-37 |
SGD |
| CDC39/YCR093W | TAS: Traceable Author Statement Assigned on 2001-01-18 |
manually curated | Collart MA and Struhl K (1994) NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization. Genes Dev 8(5):525-37 |
SGD |
| CSE2/YNR010W | IMP: Inferred from Mutant Phenotype Assigned on 2011-07-18 |
manually curated | Han SJ, et al. (2001) Med9/Cse2 and Gal11 modules are required for transcriptional repression of distinct group of genes. J Biol Chem 276(40):37020-6 |
SGD |
| DAL80/YKR034W | IMP: Inferred from Mutant Phenotype Assigned on 2009-11-17 |
manually curated | Daugherty JR, et al. (1993) Regulatory circuit for responses of nitrogen catabolic gene expression to the GLN3 and DAL80 proteins and nitrogen catabolite repression in Saccharomyces cerevisiae. J Bacteriol 175(1):64-73 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2010-02-04 |
manually curated | Cunningham TS, et al. (1994) The UGA4 UASNTR site required for GLN3-dependent transcriptional activation also mediates DAL80-responsive regulation and DAL80 protein binding in Saccharomyces cerevisiae. J Bacteriol 176(15):4718-25 |
SGD | |
| IMP: Inferred from Mutant Phenotype Assigned on 2010-02-04 |
manually curated | Andre B, et al. (1995) Two mutually exclusive regulatory systems inhibit UASGATA, a cluster of 5'-GAT(A/T)A-3' upstream from the UGA4 gene of Saccharomyces cerevisiae. Nucleic Acids Res 23(4):558-64 |
SGD | |
| DAT1/YML113W | IMP: Inferred from Mutant Phenotype Assigned on 2002-06-17 |
manually curated | Reardon BJ, et al. (1993) A peptide motif that recognizes A.T tracts in DNA. Proc Natl Acad Sci U S A 90(23):11327-31 |
SGD |
| DEP1/YAL013W | IMP: Inferred from Mutant Phenotype Assigned on 2011-07-20 |
manually curated | Carrozza MJ, et al. (2005) Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex. Biochim Biophys Acta 1731(2):77-87; discussion 75-6 |
SGD |
| ESS1/YJR017C | IGI: Inferred from Genetic Interaction with SGD:DST1, SGD:SPT4, SGD:SPT5, IMP: Inferred from Mutant Phenotype Assigned on 2011-06-06 |
manually curated | Wu X, et al. (2003) The ESS1 prolyl isomerase and its suppressor BYE1 interact with RNA pol II to inhibit transcription elongation in Saccharomyces cerevisiae. Genetics 165(4):1687-702 |
SGD |
| GAC1/YOR178C | TAS: Traceable Author Statement Assigned on 2001-01-18 |
manually curated | Tu J and Carlson M (1995) REG1 binds to protein phosphatase type 1 and regulates glucose repression in Saccharomyces cerevisiae. EMBO J 14(23):5939-46 |
SGD |
| GAL11/YOL051W | IMP: Inferred from Mutant Phenotype Assigned on 2011-07-18 |
manually curated | Han SJ, et al. (2001) Med9/Cse2 and Gal11 modules are required for transcriptional repression of distinct group of genes. J Biol Chem 276(40):37020-6 |
SGD |
| GAL80/YML051W | IMP: Inferred from Mutant Phenotype Assigned on 2011-06-22 |
manually curated | Torchia TE, et al. (1984) Disruption of regulatory gene GAL80 in Saccharomyces cerevisiae: effects on carbon-controlled regulation of the galactose/melibiose pathway genes. Mol Cell Biol 4(8):1521-7 |
SGD |
| GCN4/YEL009C | IMP: Inferred from Mutant Phenotype Assigned on 2010-03-26 |
manually curated | Velasco I, et al. (2004) Saccharomyces cerevisiae Aqr1 is an internal-membrane transporter involved in excretion of amino acids. Eukaryot Cell 3(6):1492-503 |
SGD |
| GIS1/YDR096W | IMP: Inferred from Mutant Phenotype Assigned on 2011-07-07 |
manually curated | Jang YK, et al. (1999) RPH1 and GIS1 are damage-responsive repressors of PHR1. Mol Cell Biol 19(11):7630-8 |
SGD |
| GZF3/YJL110C | IMP: Inferred from Mutant Phenotype Assigned on 2010-03-26 |
manually curated | Coffman JA, et al. (1997) Cross regulation of four GATA factors that control nitrogen catabolic gene expression in Saccharomyces cerevisiae. J Bacteriol 179(11):3416-29 |
SGD |
| HDA1/YNL021W | IMP: Inferred from Mutant Phenotype Assigned on 2009-05-15 |
manually curated | Wu J, et al. (2001) TUP1 utilizes histone H3/H2B-specific HDA1 deacetylase to repress gene activity in yeast. Mol Cell 7(1):117-26 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2010-07-12 |
manually curated | Agricola E, et al. (2006) H4 acetylation does not replace H3 acetylation in chromatin remodelling and transcription activation of Adr1-dependent genes. Mol Microbiol 62(5):1433-46 |
SGD | |
| HDA2/YDR295C | IMP: Inferred from Mutant Phenotype Assigned on 2009-05-15 |
manually curated | Wu J, et al. (2001) HDA2 and HDA3 are related proteins that interact with and are essential for the activity of the yeast histone deacetylase HDA1. Proc Natl Acad Sci U S A 98(8):4391-6 |
SGD |
| HDA3/YPR179C | IMP: Inferred from Mutant Phenotype Assigned on 2009-05-15 |
manually curated | Wu J, et al. (2001) HDA2 and HDA3 are related proteins that interact with and are essential for the activity of the yeast histone deacetylase HDA1. Proc Natl Acad Sci U S A 98(8):4391-6 |
SGD |
| HTA1/YDR225W | IMP: Inferred from Mutant Phenotype Assigned on 2007-06-04 |
manually curated | Dobi KC and Winston F (2007) Analysis of transcriptional activation at a distance in Saccharomyces cerevisiae. Mol Cell Biol 27(15):5575-86 |
SGD |
| HTB1/YDR224C | IMP: Inferred from Mutant Phenotype Assigned on 2007-06-04 |
manually curated | Dobi KC and Winston F (2007) Analysis of transcriptional activation at a distance in Saccharomyces cerevisiae. Mol Cell Biol 27(15):5575-86 |
SGD |
| IXR1/YKL032C | IMP: Inferred from Mutant Phenotype Assigned on 2010-02-24 |
manually curated | Bourdineaud JP, et al. (2000) A Rox1-independent hypoxic pathway in yeast. Antagonistic action of the repressor Ord1 and activator Yap1 for hypoxic expression of the SRP1/TIR1 gene. Mol Microbiol 38(4):879-90 |
SGD |
| LAP3/YNL239W | IMP: Inferred from Mutant Phenotype Assigned on 2011-06-23 |
manually curated | Zheng W, et al. (1997) The cysteine-peptidase bleomycin hydrolase is a member of the galactose regulon in yeast. J Biol Chem 272(48):30350-5 |
SGD |
| LEU3/YLR451W | IDA: Inferred from Direct Assay Assigned on 2011-12-13 |
manually curated | Sze JY, et al. (1992) In vitro transcriptional activation by a metabolic intermediate: activation by Leu3 depends on alpha-isopropylmalate. Science 258(5085):1143-5 |
SGD |
| MCM1/YMR043W | IDA: Inferred from Direct Assay Assigned on 2012-01-30 |
manually curated | Acton TB, et al. (1997) DNA-binding specificity of Mcm1: operator mutations that alter DNA-bending and transcriptional activities by a MADS box protein. Mol Cell Biol 17(4):1881-9 |
SGD |
| IMP: Inferred from Mutant Phenotype Assigned on 2012-01-30 |
manually curated | Abraham DS and Vershon AK (2005) N-terminal arm of Mcm1 is required for transcription of a subset of genes involved in maintenance of the cell wall. Eukaryot Cell 4(11):1808-19 |
SGD | |
| MED1/YPR070W | IMP: Inferred from Mutant Phenotype Assigned on 2011-07-27 |
manually curated | Balciunas D, et al. (1999) The Med1 subunit of the yeast mediator complex is involved in both transcriptional activation and repression. Proc Natl Acad Sci U S A 96(2):376-81 |
SGD |
| MED11/YMR112C | IMP: Inferred from Mutant Phenotype Assigned on 2011-08-15 |
manually curated | Han SJ, et al. (1999) Activator-specific requirement of yeast mediator proteins for RNA polymerase II transcriptional activation. Mol Cell Biol 19(2):979-88 |
SGD |
