Ontology: Biological Process (GO:0000011)

Definition: The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton.

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term vacuole inheritance (18 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	vacuole inheritance	18
High-throughput	none	none
Computational (download data)	vacuole inheritance	1

Links to Additional Annotations:

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• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term vacuole inheritance or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

vacuole inheritance      18 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ACT1/YFL039C	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2006-10-19	manually curated	Hill KL, et al.  (1996) Actin and myosin function in directed vacuole movement during cell division in Saccharomyces cerevisiae. J Cell Biol 135(6 Pt 1):1535-49	SGD
CLA4/YNL298W	IGI: Inferred from Genetic Interaction with SGD:VAC17, IMP: Inferred from Mutant Phenotype Assigned on 2009-04-02	manually curated	Bartholomew CR and Hardy CF  (2009) p21-activated kinases Cla4 and Ste20 regulate vacuole inheritance in Saccharomyces cerevisiae. Eukaryot Cell 8(4):560-72	SGD
MYO2/YOR326W	IGI: Inferred from Genetic Interaction with SGD:VAC17, IPI: Inferred from Physical Interaction with SGD:VAC17 Assigned on 2006-10-19	manually curated	Tang F, et al.  (2003) Regulated degradation of a class V myosin receptor directs movement of the yeast vacuole. Nature 422(6927):87-92	SGD
	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype Assigned on 2006-10-19	manually curated	Hill KL, et al.  (1996) Actin and myosin function in directed vacuole movement during cell division in Saccharomyces cerevisiae. J Cell Biol 135(6 Pt 1):1535-49	SGD
PEP12/YOR036W	IMP: Inferred from Mutant Phenotype Assigned on 2010-05-21	manually curated	Raymond CK, et al.  (1992) Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants. Mol Biol Cell 3(12):1389-402	SGD
PEP7/YDR323C	IMP: Inferred from Mutant Phenotype Assigned on 2010-05-21	manually curated	Raymond CK, et al.  (1992) Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants. Mol Biol Cell 3(12):1389-402	SGD
STE20/YHL007C	IGI: Inferred from Genetic Interaction with SGD:VAC17, IMP: Inferred from Mutant Phenotype Assigned on 2009-04-02	manually curated	Bartholomew CR and Hardy CF  (2009) p21-activated kinases Cla4 and Ste20 regulate vacuole inheritance in Saccharomyces cerevisiae. Eukaryot Cell 8(4):560-72	SGD
TPM1/YNL079C	TAS: Traceable Author Statement Assigned on 2001-01-18	manually curated	Pruyne D and Bretscher A  (2000) Polarization of cell growth in yeast. J Cell Sci 113 ( Pt 4):571-85	SGD
TPM2/YIL138C	TAS: Traceable Author Statement Assigned on 2001-01-18	manually curated	Pruyne D and Bretscher A  (2000) Polarization of cell growth in yeast. J Cell Sci 113 ( Pt 4):571-85	SGD
TRX1/YLR043C	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Xu Z and Wickner W  (1996) Thioredoxin is required for vacuole inheritance in Saccharomyces cerevisiae. J Cell Biol 132(5):787-94	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Xu Z, et al.  (1997) A heterodimer of thioredoxin and I(B)2 cooperates with Sec18p (NSF) to promote yeast vacuole inheritance. J Cell Biol 136(2):299-306	SGD
TRX2/YGR209C	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Xu Z and Wickner W  (1996) Thioredoxin is required for vacuole inheritance in Saccharomyces cerevisiae. J Cell Biol 132(5):787-94	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Xu Z, et al.  (1997) A heterodimer of thioredoxin and I(B)2 cooperates with Sec18p (NSF) to promote yeast vacuole inheritance. J Cell Biol 136(2):299-306	SGD
VAC17/YCL063W	IEP: Inferred from Expression Pattern, IGI: Inferred from Genetic Interaction with SGD:MYO2, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:MYO2, SGD:VAC8 Assigned on 2006-10-19	manually curated	Tang F, et al.  (2003) Regulated degradation of a class V myosin receptor directs movement of the yeast vacuole. Nature 422(6927):87-92	SGD
VAC8/YEL013W	IMP: Inferred from Mutant Phenotype Assigned on 2010-01-25	manually curated	Wang YX, et al.  (1996) Multiple classes of yeast mutants are defective in vacuole partitioning yet target vacuole proteins correctly. Mol Biol Cell 7(9):1375-89	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2007-10-10	manually curated	Hou H, et al.  (2005) The DHHC protein Pfa3 affects vacuole-associated palmitoylation of the fusion factor Vac8. Proc Natl Acad Sci U S A 102(48):17366-71	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR026958 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
VPS15/YBR097W	IMP: Inferred from Mutant Phenotype Assigned on 2010-05-21	manually curated	Raymond CK, et al.  (1992) Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants. Mol Biol Cell 3(12):1389-402	SGD
VPS21/YOR089C	IMP: Inferred from Mutant Phenotype Assigned on 2010-05-21	manually curated	Raymond CK, et al.  (1992) Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants. Mol Biol Cell 3(12):1389-402	SGD
VPS3/YDR495C	IMP: Inferred from Mutant Phenotype Assigned on 2010-05-21	manually curated	Raymond CK, et al.  (1992) Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants. Mol Biol Cell 3(12):1389-402	SGD
VPS45/YGL095C	IMP: Inferred from Mutant Phenotype Assigned on 2010-05-21	manually curated	Raymond CK, et al.  (1992) Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants. Mol Biol Cell 3(12):1389-402	SGD
VPS9/YML097C	IMP: Inferred from Mutant Phenotype Assigned on 2010-05-21	manually curated	Raymond CK, et al.  (1992) Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants. Mol Biol Cell 3(12):1389-402	SGD
YPT7/YML001W	IDA: Inferred from Direct Assay Assigned on 2001-01-18	manually curated	Haas A, et al.  (1995) The GTPase Ypt7p of Saccharomyces cerevisiae is required on both partner vacuoles for the homotypic fusion step of vacuole inheritance. EMBO J 14(21):5258-70	SGD

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