Ontology: Biological Process (GO:0030036)

Definition: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.

Synonyms: actin modulating activity; actin cytoskeleton organization and biogenesis; actin cytoskeleton organisation

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term actin cytoskeleton organization (31 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	actin cytoskeleton organization	26
High-throughput	none	none
Computational (download data)	actin cytoskeleton organization	6

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term actin cytoskeleton organization or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

actin cytoskeleton organization      31 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ACF2/YLR144C	IDA: Inferred from Direct Assay Assigned on 2002-08-07	manually curated	Lechler T and Li R  (1997) In vitro reconstitution of cortical actin assembly sites in budding yeast. J Cell Biol 138(1):95-103	SGD
AKL1/YBR059C	IMP: Inferred from Mutant Phenotype Assigned on 2004-05-20	manually curated	Henry KR, et al.  (2003) The actin-regulating kinase Prk1p negatively regulates Scd5p, a suppressor of clathrin deficiency, in actin organization and endocytosis. Curr Biol 13(17):1564-9	SGD
APP1/YNL094W	IPI: Inferred from Physical Interaction Assigned on 2002-07-18	manually curated	Bon E, et al.  (2000) A network of proteins around Rvs167p and Rvs161p, two proteins related to the yeast actin cytoskeleton. Yeast 16(13):1229-41	SGD
ARC35/YNR035C	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2004-10-31	manually curated	Schaerer-Brodbeck C and Riezman H  (2003) Genetic and biochemical interactions between the Arp2/3 complex, Cmd1p, casein kinase II, and Tub4p in yeast. FEMS Yeast Res 4(1):37-49	SGD
BBC1/YJL020C	IGI: Inferred from Genetic Interaction, IPI: Inferred from Physical Interaction Assigned on 2002-11-26	manually curated	Mochida J, et al.  (2002) The novel adaptor protein, Mti1p, and Vrp1p, a homolog of Wiskott-Aldrich syndrome protein-interacting protein (WIP), may antagonistically regulate type I myosins in Saccharomyces cerevisiae. Genetics 160(3):923-34	SGD
BEM2/YER155C	IGI: Inferred from Genetic Interaction Assigned on 2001-07-05	manually curated	Wang T and Bretscher A  (1995) The rho-GAP encoded by BEM2 regulates cytoskeletal structure in budding yeast. Mol Biol Cell 6(8):1011-24	SGD
	TAS: Traceable Author Statement Assigned on 2001-07-05	manually curated	Madden K and Snyder M  (1998) Cell polarity and morphogenesis in budding yeast. Annu Rev Microbiol 52():687-744	SGD
BEM4/YPL161C	TAS: Traceable Author Statement Assigned on 2002-01-03	manually curated	Madden K and Snyder M  (1998) Cell polarity and morphogenesis in budding yeast. Annu Rev Microbiol 52():687-744	SGD
BNI1/YNL271C	IEA: Inferred from Electronic Annotation with EBI:IPR003104, EBI:IPR010473 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
BNR1/YIL159W	IEA: Inferred from Electronic Annotation with EBI:IPR003104 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CAP1/YKL007W	IEA: Inferred from Electronic Annotation with EBI:IPR002189, EBI:IPR017865 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CAP2/YIL034C	IEA: Inferred from Electronic Annotation with EBI:IPR019771, EBI:IPR001698 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CDC1/YDR182W	IMP: Inferred from Mutant Phenotype Assigned on 2003-09-17	manually curated	Rossanese OW, et al.  (2001) A role for actin, Cdc1p, and Myo2p in the inheritance of late Golgi elements in Saccharomyces cerevisiae. J Cell Biol 153(1):47-62	SGD
GEA1/YJR031C	IGI: Inferred from Genetic Interaction with SGD:PFY1 Assigned on 2005-01-03	manually curated	Zakrzewska E, et al.  (2003) A role for GEA1 and GEA2 in the organization of the actin cytoskeleton in Saccharomyces cerevisiae. Genetics 165(3):985-95	SGD
GEA2/YEL022W	IGI: Inferred from Genetic Interaction with SGD:PFY1 Assigned on 2005-01-03	manually curated	Zakrzewska E, et al.  (2003) A role for GEA1 and GEA2 in the organization of the actin cytoskeleton in Saccharomyces cerevisiae. Genetics 165(3):985-95	SGD
GRX3/YDR098C	IMP: Inferred from Mutant Phenotype Assigned on 2011-03-18	manually curated	Pujol-Carrion N and de la Torre-Ruiz MA  (2010) Glutaredoxins Grx4 and Grx3 of Saccharomyces cerevisiae Play a Role in Actin Dynamics through Their Trx Domains, Which Contributes to Oxidative Stress Resistance. Appl Environ Microbiol 76(23):7826-7835	SGD
GRX4/YER174C	IMP: Inferred from Mutant Phenotype Assigned on 2011-03-18	manually curated	Pujol-Carrion N and de la Torre-Ruiz MA  (2010) Glutaredoxins Grx4 and Grx3 of Saccharomyces cerevisiae Play a Role in Actin Dynamics through Their Trx Domains, Which Contributes to Oxidative Stress Resistance. Appl Environ Microbiol 76(23):7826-7835	SGD
LSB5/YCL034W	IGI: Inferred from Genetic Interaction with SGD:YSC84 Assigned on 2009-09-25	manually curated	Dewar H, et al.  (2002) Novel proteins linking the actin cytoskeleton to the endocytic machinery in Saccharomyces cerevisiae. Mol Biol Cell 13(10):3646-61	SGD
PFY1/YOR122C	IEA: Inferred from Electronic Annotation with EBI:IPR005455 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
RHO1/YPR165W	IMP: Inferred from Mutant Phenotype Assigned on 2009-11-13	manually curated	Marelli M, et al.  (2004) Quantitative mass spectrometry reveals a role for the GTPase Rho1p in actin organization on the peroxisome membrane. J Cell Biol 167(6):1099-112	SGD
RVS161/YCR009C	IMP: Inferred from Mutant Phenotype Assigned on 2009-03-13	manually curated	Sivadon P, et al.  (1995) Actin cytoskeleton and budding pattern are altered in the yeast rvs161 mutant: the Rvs161 protein shares common domains with the brain protein amphiphysin. Mol Gen Genet 246(4):485-95	SGD
SDA1/YGR245C	IMP: Inferred from Mutant Phenotype Assigned on 2002-10-01	manually curated	Buscemi G, et al.  (2000) The Saccharomyces cerevisiae SDA1 gene is required for actin cytoskeleton organization and cell cycle progression. J Cell Sci 113 ( Pt 7)():1199-211	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR027312 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
SFK1/YKL051W	IGI: Inferred from Genetic Interaction with SGD:STT4 Assigned on 2006-11-08	manually curated	Audhya A and Emr SD  (2002) Stt4 PI 4-kinase localizes to the plasma membrane and functions in the Pkc1-mediated MAP kinase cascade. Dev Cell 2(5):593-605	SGD
SHE4/YOR035C	TAS: Traceable Author Statement Assigned on 2003-06-16	manually curated	Takizawa PA and Vale RD  (2000) The myosin motor, Myo4p, binds Ash1 mRNA via the adapter protein, She3p. Proc Natl Acad Sci U S A 97(10):5273-8	SGD
SIT4/YDL047W	IMP: Inferred from Mutant Phenotype Assigned on 2002-12-11	manually curated	Angeles de la Torre-Ruiz M, et al.  (2002) Sit4 is required for proper modulation of the biological functions mediated by Pkc1 and the cell integrity pathway in Saccharomyces cerevisiae. J Biol Chem 277(36):33468-76	SGD
SLG1/YOR008C	IMP: Inferred from Mutant Phenotype Assigned on 2003-01-16	manually curated	Delley PA and Hall MN  (1999) Cell wall stress depolarizes cell growth via hyperactivation of RHO1. J Cell Biol 147(1):163-74	SGD
SLM1/YIL105C	IGI: Inferred from Genetic Interaction with SGD:SLM2 Assigned on 2005-01-06	manually curated	Audhya A, et al.  (2004) Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton. EMBO J 23(19):3747-57	SGD
	IGI: Inferred from Genetic Interaction with SGD:SLM2 Assigned on 2005-04-18	manually curated	Fadri M, et al.  (2005) The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2. Mol Biol Cell 16(4):1883-900	SGD
SLM2/YNL047C	IGI: Inferred from Genetic Interaction with SGD:SLM1 Assigned on 2005-01-06	manually curated	Audhya A, et al.  (2004) Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton. EMBO J 23(19):3747-57	SGD
	IGI: Inferred from Genetic Interaction Assigned on 2005-04-18	manually curated	Fadri M, et al.  (2005) The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2. Mol Biol Cell 16(4):1883-900	SGD
SSK2/YNR031C	IDA: Inferred from Direct Assay Assigned on 2003-02-14	manually curated	Yuzyuk T, et al.  (2002) The MEK kinase Ssk2p promotes actin cytoskeleton recovery after osmotic stress. Mol Biol Cell 13(8):2869-80	SGD
VPS1/YKR001C	IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2004-10-18	manually curated	Yu X and Cai M  (2004) The yeast dynamin-related GTPase Vps1p functions in the organization of the actin cytoskeleton via interaction with Sla1p. J Cell Sci 117(Pt 17):3839-53	SGD
VRP1/YLR337C	IGI: Inferred from Genetic Interaction with SGD:ACT1, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction with SGD:ACT1 Assigned on 2007-08-10	manually curated	Vaduva G, et al.  (1997) Actin-binding verprolin is a polarity development protein required for the morphogenesis and function of the yeast actin cytoskeleton. J Cell Biol 139(7):1821-33	SGD

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