Ontology: Biological Process (GO:0009408)

Definition: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.

Synonyms: response to heat shock

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term response to heat (17 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	response to heat	16
High-throughput	none	none
Computational (download data)	response to heat	2

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term response to heat or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

response to heat      17 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
GAC1/YOR178C	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2001-01-18	manually curated	Lin JT and Lis JT  (1999) Glycogen synthase phosphatase interacts with heat shock factor to activate CUP1 gene transcription in Saccharomyces cerevisiae. Mol Cell Biol 19(5):3237-45	SGD
GET3/YDL100C	IMP: Inferred from Mutant Phenotype Assigned on 2004-01-07	manually curated	Shen J, et al.  (2003) The Saccharomyces cerevisiae Arr4p is involved in metal and heat tolerance. Biometals 16(3):369-78	SGD
GLC7/YER133W	IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction Assigned on 2001-01-18	manually curated	Lin JT and Lis JT  (1999) Glycogen synthase phosphatase interacts with heat shock factor to activate CUP1 gene transcription in Saccharomyces cerevisiae. Mol Cell Biol 19(5):3237-45	SGD
HSF1/YGL073W	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Nwaka S, et al.  (1996) The heat shock factor and mitochondrial Hsp70 are necessary for survival of heat shock in Saccharomyces cerevisiae. FEBS Lett 399(3):259-63	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Wiederrecht G, et al.  (1988) Isolation of the gene encoding the S. cerevisiae heat shock transcription factor. Cell 54(6):841-53	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Smith BJ and Yaffe MP  (1991) A mutation in the yeast heat-shock factor gene causes temperature-sensitive defects in both mitochondrial protein import and the cell cycle. Mol Cell Biol 11(5):2647-55	SGD
LCB5/YLR260W	IDA: Inferred from Direct Assay Assigned on 2002-08-30	manually curated	Ferguson-Yankey SR, et al.  (2002) Mutant analysis reveals complex regulation of sphingolipid long chain base phosphates and long chain bases during heat stress in yeast. Yeast 19(7):573-86	SGD
LSP1/YPL004C	IMP: Inferred from Mutant Phenotype Assigned on 2004-06-30	manually curated	Zhang X, et al.  (2004) Pil1p and Lsp1p negatively regulate the 3-phosphoinositide-dependent protein kinase-like kinase Pkh1p and downstream signaling pathways Pkc1p and Ypk1p. J Biol Chem 279(21):22030-8	SGD
MDJ1/YFL016C	IMP: Inferred from Mutant Phenotype Assigned on 2008-06-03	manually curated	Prip-Buus C, et al.  (1996) Role of the mitochondrial DnaJ homologue, Mdj1p, in the prevention of heat-induced protein aggregation. FEBS Lett 380(1-2):142-6	SGD
	IEA: Inferred from Electronic Annotation with EBI:IPR012724 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
NBP2/YDR162C	IMP: Inferred from Mutant Phenotype Assigned on 2004-10-14	manually curated	Ohkuni K, et al.  (2003) Yeast Nap1-binding protein Nbp2p is required for mitotic growth at high temperatures and for cell wall integrity. Genetics 165(2):517-29	SGD
PIL1/YGR086C	IMP: Inferred from Mutant Phenotype Assigned on 2004-06-30	manually curated	Zhang X, et al.  (2004) Pil1p and Lsp1p negatively regulate the 3-phosphoinositide-dependent protein kinase-like kinase Pkh1p and downstream signaling pathways Pkc1p and Ypk1p. J Biol Chem 279(21):22030-8	SGD
SGT2/YOR007C	IMP: Inferred from Mutant Phenotype Assigned on 2006-08-07	manually curated	Angeletti PC, et al.  (2002) Small glutamine-rich protein/viral protein U-binding protein is a novel cochaperone that affects heat shock protein 70 activity. Cell Stress Chaperones 7(3):258-68	SGD
SLG1/YOR008C	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Delley PA and Hall MN  (1999) Cell wall stress depolarizes cell growth via hyperactivation of RHO1. J Cell Biol 147(1):163-74	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	manually curated	Ketela T, et al.  (1999) Saccharomyces cerevisiae mid2p is a potential cell wall stress sensor and upstream activator of the PKC1-MPK1 cell integrity pathway. J Bacteriol 181(11):3330-40	SGD
WHI2/YOR043W	IMP: Inferred from Mutant Phenotype Assigned on 2004-10-19	manually curated	Kaida D, et al.  (2002) Yeast Whi2 and Psr1-phosphatase form a complex and regulate STRE-mediated gene expression. Genes Cells 7(6):543-52	UniProtKB
WSC2/YNL283C	ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18	manually curated	Delley PA and Hall MN  (1999) Cell wall stress depolarizes cell growth via hyperactivation of RHO1. J Cell Biol 147(1):163-74	SGD
	IGI: Inferred from Genetic Interaction Assigned on 2001-01-18	manually curated	Ketela T, et al.  (1999) Saccharomyces cerevisiae mid2p is a potential cell wall stress sensor and upstream activator of the PKC1-MPK1 cell integrity pathway. J Bacteriol 181(11):3330-40	SGD
WSC3/YOL105C	ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18	manually curated	Delley PA and Hall MN  (1999) Cell wall stress depolarizes cell growth via hyperactivation of RHO1. J Cell Biol 147(1):163-74	SGD
	IGI: Inferred from Genetic Interaction Assigned on 2001-01-18	manually curated	Ketela T, et al.  (1999) Saccharomyces cerevisiae mid2p is a potential cell wall stress sensor and upstream activator of the PKC1-MPK1 cell integrity pathway. J Bacteriol 181(11):3330-40	SGD
WSC4/YHL028W	IGI: Inferred from Genetic Interaction with SGD:SLG1 Assigned on 2005-07-11	manually curated	Zu T, et al.  (2001) Mutations in WSC genes for putative stress receptors result in sensitivity to multiple stress conditions and impairment of Rlm1-dependent gene expression in Saccharomyces cerevisiae. Mol Genet Genomics 266(1):142-55	SGD
YAP1/YML007W	IMP: Inferred from Mutant Phenotype Assigned on 2006-12-11	manually curated	Sugiyama K, et al.  (2000) The Yap1p-dependent induction of glutathione synthesis in heat shock response of Saccharomyces cerevisiae. J Biol Chem 275(20):15535-40	SGD
YDJ1/YNL064C	IEA: Inferred from Electronic Annotation with EBI:IPR012724 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro

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