Ontology: Cellular Component (GO:0000784)

Definition: The terminal region of a linear chromosome in the nucleus that includes the telomeric DNA repeats and associated proteins.

Synonyms: nuclear chromosome, telomere

View Ontology: (graph) | (text)

This table lists the methods used to annotate genes either directly to the term nuclear chromosome, telomeric region (13 genes) or to its variants containing one or more qualifiers (0 genes). Note that some genes may have been annotated by more than one method so the numbers in the table below may not add up to the totals given here.

Annotation Method	GO Term	# Yeast Genes Annotated
Manually curated (download data)	nuclear chromosome, telomeric region	12
High-throughput	none	none
Computational (download data)	nuclear chromosome, telomeric region	1

Links to Additional Annotations:

• View annotations in multiple organisms using
• Search for S. cerevisiae genes annotated, by the Manually curated or High-throughput methods, to this term or to any terms that are descended from this term, i.e., child terms representing more specific biology than this term.

Annotation details for genes that have been directly annotated to the term nuclear chromosome, telomeric region or its variants containing one or more qualifiers (NOT, contributes to, or colocalizes with).

nuclear chromosome, telomeric region      13 genes directly annotated to this term
Locus	Evidence	Annotation Method	Reference	Assigned By
ASF2/YDL197C	IDA: Inferred from Direct Assay Assigned on 2004-10-08	manually curated	Sundin BA, et al.  (2004) Localization of proteins that are coordinately expressed with Cln2 during the cell cycle. Yeast 21(9):793-800	SGD
CDC13/YDL220C	IEA: Inferred from Electronic Annotation with EBI:IPR011564 Last Updated 2013-03-02	computational	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
CSM4/YPL200W	IDA: Inferred from Direct Assay Assigned on 2008-08-01	manually curated	Conrad MN, et al.  (2008) Rapid telomere movement in meiotic prophase is promoted by NDJ1, MPS3, and CSM4 and is modulated by recombination. Cell 133(7):1175-87	SGD
DNA2/YHR164C	IDA: Inferred from Direct Assay Assigned on 2004-11-07	manually curated	Choe W, et al.  (2002) Dynamic localization of an Okazaki fragment processing protein suggests a novel role in telomere replication. Mol Cell Biol 22(12):4202-17	SGD
HEK2/YBL032W	IDA: Inferred from Direct Assay Assigned on 2003-04-03	manually curated	Denisenko O and Bomsztyk K  (2002) Yeast hnRNP K-like genes are involved in regulation of the telomeric position effect and telomere length. Mol Cell Biol 22(1):286-97	SGD
MCM5/YLR274W	IDA: Inferred from Direct Assay Assigned on 2009-01-23	manually curated	Rehman MA, et al.  (2009) Subtelomeric ACS-containing proto-silencers act as antisilencers in replication factors mutants in Saccharomyces cerevisiae. Mol Biol Cell 20(2):631-41	SGD
MPS3/YJL019W	IDA: Inferred from Direct Assay Assigned on 2008-08-01	manually curated	Conrad MN, et al.  (2007) MPS3 mediates meiotic bouquet formation in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 104(21):8863-8	SGD
NDJ1/YOL104C	IDA: Inferred from Direct Assay Assigned on 2003-04-03	manually curated	Conrad MN, et al.  (1997) Ndj1p, a meiotic telomere protein required for normal chromosome synapsis and segregation in yeast. Science 276(5316):1252-5	SGD
	IDA: Inferred from Direct Assay Assigned on 2008-08-04	manually curated	Chua PR and Roeder GS  (1997) Tam1, a telomere-associated meiotic protein, functions in chromosome synapsis and crossover interference. Genes Dev 11(14):1786-800	SGD
RAP1/YNL216W	IDA: Inferred from Direct Assay Assigned on 2012-05-02	manually curated	Clement M, et al.  (2006) The nuclear GTPase Gsp1p can affect proper telomeric function through the Sir4 protein in Saccharomyces cerevisiae. Mol Microbiol 62(2):453-468	SGD
SAS2/YMR127C	IC: Inferred By Curator from chromatin silencing at telomere Assigned on 2003-04-03	manually curated	Osada S, et al.  (2001) The yeast SAS (something about silencing) protein complex contains a MYST-type putative acetyltransferase and functions with chromatin assembly factor ASF1. Genes Dev 15(23):3155-68	SGD
SAS4/YDR181C	IC: Inferred By Curator from chromatin silencing at telomere Assigned on 2003-04-03	manually curated	Osada S, et al.  (2001) The yeast SAS (something about silencing) protein complex contains a MYST-type putative acetyltransferase and functions with chromatin assembly factor ASF1. Genes Dev 15(23):3155-68	SGD
SAS5/YOR213C	IC: Inferred By Curator from chromatin silencing at telomere Assigned on 2003-04-03	manually curated	Osada S, et al.  (2001) The yeast SAS (something about silencing) protein complex contains a MYST-type putative acetyltransferase and functions with chromatin assembly factor ASF1. Genes Dev 15(23):3155-68	SGD
TBF1/YPL128C	IDA: Inferred from Direct Assay Assigned on 2011-09-19	manually curated	Preti M, et al.  (2010) The Telomere-Binding Protein Tbf1 Demarcates snoRNA Gene Promoters in Saccharomyces cerevisiae. Mol Cell 38(4):614-620	SGD

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