This page displays GO annotations in different sections according to the annotation method used to add that annotation to SGD.

Last Reviewed on: 2008-06-18    Molecular Function | Biological Process | Cellular Component

Manually curated Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
RNA binding	IDA: Inferred from Direct Assay Assigned on 2007-09-17 IPI: Inferred from Physical Interaction with SGD:RDN37-2, SGD:RDN37-1 Assigned on 2006-10-24	Tollervey D  (1987) A yeast small nuclear RNA is required for normal processing of pre-ribosomal RNA. EMBO J 6(13):4169-75	SGD
rRNA pseudouridylation guide activity	IMP: Inferred from Mutant Phenotype Assigned on 2006-09-11	Ni J, et al.  (1997) Small nucleolar RNAs direct site-specific synthesis of pseudouridine in ribosomal RNA. Cell 89(4):565-73	SGD

Manually curated Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP: Inferred from Mutant Phenotype Assigned on 2008-06-18	Tollervey D  (1987) A yeast small nuclear RNA is required for normal processing of pre-ribosomal RNA. EMBO J 6(13):4169-75	SGD
endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP: Inferred from Mutant Phenotype Assigned on 2008-06-18	Tollervey D  (1987) A yeast small nuclear RNA is required for normal processing of pre-ribosomal RNA. EMBO J 6(13):4169-75	SGD
rRNA pseudouridine synthesis	IMP: Inferred from Mutant Phenotype Assigned on 2006-09-11	Ni J, et al.  (1997) Small nucleolar RNAs direct site-specific synthesis of pseudouridine in ribosomal RNA. Cell 89(4):565-73	SGD

Manually curated Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
box H/ACA snoRNP complex	IPI: Inferred from Physical Interaction with SGD:NHP2, SGD:GAR1 Assigned on 2006-09-08	Torchet C, et al.  (2005) The complete set of H/ACA snoRNAs that guide rRNA pseudouridylations in Saccharomyces cerevisiae. RNA 11(6):928-38	SGD
	IPI: Inferred from Physical Interaction with SGD:CBF5 Assigned on 2006-09-20	Lafontaine DLJ, et al.  (1998) The box H + ACA snoRNAs carry Cbf5p, the putative rRNA pseudouridine synthase. Genes Dev 12(4):527-37	SGD
nucleolus	IDA: Inferred from Direct Assay Assigned on 2006-09-19	Morrissey JP and Tollervey D  (1993) Yeast snR30 is a small nucleolar RNA required for 18S rRNA synthesis. Mol Cell Biol 13(4):2469-77	SGD
	IPI: Inferred from Physical Interaction with SGD:SBP1 Assigned on 2002-11-18	Clark MW, et al.  (1990) SSB-1 of the yeast Saccharomyces cerevisiae is a nucleolar-specific, silver-binding protein that is associated with the snR10 and snR11 small nuclear RNAs. J Cell Biol 111(5 Pt 1):1741-51	SGD
	IDA: Inferred from Direct Assay Assigned on 2006-10-24	Tollervey D  (1987) A yeast small nuclear RNA is required for normal processing of pre-ribosomal RNA. EMBO J 6(13):4169-75	SGD

* Manually curated GO annotations reflect our best understanding of the basic molecular function, biological process, and cellular component for this gene product. Manually curated annotations are assigned by SGD curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all Manually curated GO annotations for accuracy and completeness. The "Last Reviewed on:" date at the top of this section indicates when these annotations were last reviewed.

There are no High-throughput annotations for SNR10

** GO annotations from High-throughput experiments are made based on a variety of large scale high-throughput experiments, including genome-wide experiments. Many of these annotations are made based on GO annotations (or mappings to GO annotations) assigned by the authors, rather than SGD curators. While SGD curators read these publications and often work closely with authors to incorporate the information, each individual annotation may not necessarily be reviewed by a curator. GO Annotations from high-throughput experiments will be assigned only when this type of data is available, and thus may not be assigned in all three aspects of the Gene Ontologies.

There are no Computational annotations for SNR10

*** Computational GO Annotations are predictions. These annotations are NOT reviewed by a curator. Currently, all computational GO annotations for S. cerevisiae are assigned by an external source (for example, the Gene Ontology Annotation (GOA) project of the European Bioinformatics Institute (EBI)).