This page displays GO annotations in different sections according to the annotation method used to add that annotation to SGD.

Last Reviewed on: 2007-03-08    Molecular Function | Biological Process | Cellular Component

Manually curated Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
contributes_to ribonuclease MRP activity	IMP: Inferred from Mutant Phenotype Assigned on 2007-03-01	Lygerou Z, et al.  (1996) Accurate processing of a eukaryotic precursor ribosomal RNA by ribonuclease MRP in vitro. Science 272(5259):268-70	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2007-03-01	Schmitt ME and Clayton DA  (1993) Nuclear RNase MRP is required for correct processing of pre-5.8S rRNA in Saccharomyces cerevisiae. Mol Cell Biol 13(12):7935-41	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2007-03-01	Chu S, et al.  (1994) The RNA of RNase MRP is required for normal processing of ribosomal RNA. Proc Natl Acad Sci U S A 91(2):659-63	SGD

Manually curated Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
mRNA cleavage	IPI: Inferred from Physical Interaction Assigned on 2007-03-08	Gill T, et al.  (2004) RNase MRP cleaves the CLB2 mRNA to promote cell cycle progression: novel method of mRNA degradation. Mol Cell Biol 24(3):945-53	SGD
positive regulation of cell cycle	IMP: Inferred from Mutant Phenotype Assigned on 2007-03-01	Cai T, et al.  (2002) The Saccharomyces cerevisiae RNase mitochondrial RNA processing is critical for cell cycle progression at the end of mitosis. Genetics 161(3):1029-42	SGD
rRNA processing	IMP: Inferred from Mutant Phenotype Assigned on 2007-03-01	Schmitt ME and Clayton DA  (1993) Nuclear RNase MRP is required for correct processing of pre-5.8S rRNA in Saccharomyces cerevisiae. Mol Cell Biol 13(12):7935-41	SGD
	IDA: Inferred from Direct Assay Assigned on 2007-03-01	Lygerou Z, et al.  (1996) Accurate processing of a eukaryotic precursor ribosomal RNA by ribonuclease MRP in vitro. Science 272(5259):268-70	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2007-03-01	Chu S, et al.  (1994) The RNA of RNase MRP is required for normal processing of ribosomal RNA. Proc Natl Acad Sci U S A 91(2):659-63	SGD

Manually curated Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
ribonuclease MRP complex	IDA: Inferred from Direct Assay Assigned on 2007-03-01	Schmitt ME and Clayton DA  (1992) Yeast site-specific ribonucleoprotein endoribonuclease MRP contains an RNA component homologous to mammalian RNase MRP RNA and essential for cell viability. Genes Dev 6(10):1975-85	SGD

* Manually curated GO annotations reflect our best understanding of the basic molecular function, biological process, and cellular component for this gene product. Manually curated annotations are assigned by SGD curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all Manually curated GO annotations for accuracy and completeness. The "Last Reviewed on:" date at the top of this section indicates when these annotations were last reviewed.

There are no High-throughput annotations for NME1

** GO annotations from High-throughput experiments are made based on a variety of large scale high-throughput experiments, including genome-wide experiments. Many of these annotations are made based on GO annotations (or mappings to GO annotations) assigned by the authors, rather than SGD curators. While SGD curators read these publications and often work closely with authors to incorporate the information, each individual annotation may not necessarily be reviewed by a curator. GO Annotations from high-throughput experiments will be assigned only when this type of data is available, and thus may not be assigned in all three aspects of the Gene Ontologies.

There are no Computational annotations for NME1

*** Computational GO Annotations are predictions. These annotations are NOT reviewed by a curator. Currently, all computational GO annotations for S. cerevisiae are assigned by an external source (for example, the Gene Ontology Annotation (GOA) project of the European Bioinformatics Institute (EBI)).