This page displays GO annotations in different sections according to the annotation method used to add that annotation to SGD.

Last Reviewed on: 2006-08-23    Molecular Function | Biological Process | Cellular Component

Manually curated Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
rRNA 2'-O-ribose methylation guide activity	ISM: Inferred from Sequence Model Assigned on 2008-04-16 IMP: Inferred from Mutant Phenotype Assigned on 2006-08-18	Lowe TM and Eddy SR  (1999) A computational screen for methylation guide snoRNAs in yeast. Science 283(5405):1168-71	SGD
	ISS: Inferred from Sequence or structural Similarity Assigned on 2006-08-23	Kiss-Laszlo Z, et al.  (1996) Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs. Cell 85(7):1077-88	SGD

Manually curated Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
rRNA methylation	ISM: Inferred from Sequence Model Assigned on 2008-04-16 IMP: Inferred from Mutant Phenotype Assigned on 2006-08-18	Lowe TM and Eddy SR  (1999) A computational screen for methylation guide snoRNAs in yeast. Science 283(5405):1168-71	SGD
	ISS: Inferred from Sequence or structural Similarity Assigned on 2006-08-23	Kiss-Laszlo Z, et al.  (1996) Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs. Cell 85(7):1077-88	SGD

Manually curated Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
box C/D snoRNP complex	IC: Inferred By Curator from rRNA 2'-O-ribose methylation guide activity Assigned on 2006-08-18	Lowe TM and Eddy SR  (1999) A computational screen for methylation guide snoRNAs in yeast. Science 283(5405):1168-71	SGD
	IC: Inferred By Curator from rRNA 2'-O-ribose methylation guide activity Assigned on 2006-08-23	Kiss-Laszlo Z, et al.  (1996) Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs. Cell 85(7):1077-88	SGD
nucleolus	IC: Inferred By Curator from rRNA methylation Assigned on 2006-08-18	Lowe TM and Eddy SR  (1999) A computational screen for methylation guide snoRNAs in yeast. Science 283(5405):1168-71	SGD
	IC: Inferred By Curator from rRNA methylation Assigned on 2006-08-23	Kiss-Laszlo Z, et al.  (1996) Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs. Cell 85(7):1077-88	SGD

* Manually curated GO annotations reflect our best understanding of the basic molecular function, biological process, and cellular component for this gene product. Manually curated annotations are assigned by SGD curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all Manually curated GO annotations for accuracy and completeness. The "Last Reviewed on:" date at the top of this section indicates when these annotations were last reviewed.

There are no High-throughput annotations for SNR40

** GO annotations from High-throughput experiments are made based on a variety of large scale high-throughput experiments, including genome-wide experiments. Many of these annotations are made based on GO annotations (or mappings to GO annotations) assigned by the authors, rather than SGD curators. While SGD curators read these publications and often work closely with authors to incorporate the information, each individual annotation may not necessarily be reviewed by a curator. GO Annotations from high-throughput experiments will be assigned only when this type of data is available, and thus may not be assigned in all three aspects of the Gene Ontologies.

There are no Computational annotations for SNR40

*** Computational GO Annotations are predictions. These annotations are NOT reviewed by a curator. Currently, all computational GO annotations for S. cerevisiae are assigned by an external source (for example, the Gene Ontology Annotation (GOA) project of the European Bioinformatics Institute (EBI)).