This page displays GO annotations in different sections according to the annotation method used to add that annotation to SGD.

Last Reviewed on: 2002-07-15    Molecular Function | Biological Process | Cellular Component

Manually curated Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
pre-mRNA 5'-splice site binding	IDA: Inferred from Direct Assay Assigned on 2008-04-02	McGrail JC and O'Keefe RT  (2008) The U1, U2 and U5 snRNAs crosslink to the 5' exon during yeast pre-mRNA splicing. Nucleic Acids Res 36(3):814-25	SGD
	IGI: Inferred from Genetic Interaction Assigned on 2005-10-27 IMP: Inferred from Mutant Phenotype Assigned on 2005-10-27	Lacadie SA and Rosbash M  (2005) Cotranscriptional spliceosome assembly dynamics and the role of U1 snRNA:5'ss base pairing in yeast. Mol Cell 19(1):65-75	SGD
	IGI: Inferred from Genetic Interaction Assigned on 2005-10-27 IMP: Inferred from Mutant Phenotype Assigned on 2005-10-27	Seraphin B, et al.  (1988) A U1 snRNA:pre-mRNA base pairing interaction is required early in yeast spliceosome assembly but does not uniquely define the 5' cleavage site. EMBO J 7(8):2533-8	SGD

Manually curated Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
mRNA 5'-splice site recognition	IDA: Inferred from Direct Assay Assigned on 2008-04-02	McGrail JC and O'Keefe RT  (2008) The U1, U2 and U5 snRNAs crosslink to the 5' exon during yeast pre-mRNA splicing. Nucleic Acids Res 36(3):814-25	SGD
mRNA splicing, via spliceosome	IDA: Inferred from Direct Assay Assigned on 2002-07-15	Kretzner L, et al.  (1987) S. cerevisiae U1 RNA is large and has limited primary sequence homology to metazoan U1 snRNA. Cell 50(4):593-602	SGD

Manually curated Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
commitment complex	IDA: Inferred from Direct Assay Assigned on 2005-10-31	Seraphin B and Rosbash M  (1989) Identification of functional U1 snRNA-pre-mRNA complexes committed to spliceosome assembly and splicing. Cell 59(2):349-58	SGD
U1 snRNP	IDA: Inferred from Direct Assay Assigned on 2002-07-15	Kretzner L, et al.  (1987) S. cerevisiae U1 RNA is large and has limited primary sequence homology to metazoan U1 snRNA. Cell 50(4):593-602	SGD

* Manually curated GO annotations reflect our best understanding of the basic molecular function, biological process, and cellular component for this gene product. Manually curated annotations are assigned by SGD curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all Manually curated GO annotations for accuracy and completeness. The "Last Reviewed on:" date at the top of this section indicates when these annotations were last reviewed.

There are no High-throughput annotations for SNR19

** GO annotations from High-throughput experiments are made based on a variety of large scale high-throughput experiments, including genome-wide experiments. Many of these annotations are made based on GO annotations (or mappings to GO annotations) assigned by the authors, rather than SGD curators. While SGD curators read these publications and often work closely with authors to incorporate the information, each individual annotation may not necessarily be reviewed by a curator. GO Annotations from high-throughput experiments will be assigned only when this type of data is available, and thus may not be assigned in all three aspects of the Gene Ontologies.

There are no Computational annotations for SNR19

*** Computational GO Annotations are predictions. These annotations are NOT reviewed by a curator. Currently, all computational GO annotations for S. cerevisiae are assigned by an external source (for example, the Gene Ontology Annotation (GOA) project of the European Bioinformatics Institute (EBI)).