This page displays GO annotations in different sections according to the annotation method used to add that annotation to SGD.

Last Reviewed on: 2003-06-19    Molecular Function | Biological Process | Cellular Component

Manually curated Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
contributes_to telomerase activity	IDA: Inferred from Direct Assay Assigned on 2005-04-21	Liao XH, et al.  (2005) Characterization of recombinant Saccharomyces cerevisiae telomerase core enzyme purified from yeast. Biochem J 390(Pt 1):169-76	SGD
template for synthesis of G-rich strand of telomere DNA activity	TAS: Traceable Author Statement Assigned on 2002-06-25	Livengood AJ, et al.  (2002) Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction. Mol Cell Biol 22(7):2366-74	SGD

Manually curated Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
telomere maintenance via telomerase	IMP: Inferred from Mutant Phenotype Assigned on 2005-04-21 IDA: Inferred from Direct Assay Assigned on 2005-04-21	Liao XH, et al.  (2005) Characterization of recombinant Saccharomyces cerevisiae telomerase core enzyme purified from yeast. Biochem J 390(Pt 1):169-76	SGD
	TAS: Traceable Author Statement Assigned on 2002-06-25	Livengood AJ, et al.  (2002) Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction. Mol Cell Biol 22(7):2366-74	SGD

Manually curated Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
cytoplasm	IDA: Inferred from Direct Assay Assigned on 2002-08-28	Teixeira MT, et al.  (2002) Intracellular trafficking of yeast telomerase components. EMBO Rep 3(7):652-9	SGD
nucleus	IDA: Inferred from Direct Assay Assigned on 2002-08-28	Teixeira MT, et al.  (2002) Intracellular trafficking of yeast telomerase components. EMBO Rep 3(7):652-9	SGD
telomerase catalytic core complex	IDA: Inferred from Direct Assay Assigned on 2005-04-21 IPI: Inferred from Physical Interaction Assigned on 2005-04-21	Liao XH, et al.  (2005) Characterization of recombinant Saccharomyces cerevisiae telomerase core enzyme purified from yeast. Biochem J 390(Pt 1):169-76	SGD
	TAS: Traceable Author Statement Assigned on 2002-06-25	Livengood AJ, et al.  (2002) Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction. Mol Cell Biol 22(7):2366-74	SGD
telomerase holoenzyme complex	IDA: Inferred from Direct Assay Assigned on 2003-06-19 IPI: Inferred from Physical Interaction Assigned on 2003-06-19	Hughes TR, et al.  (2000) The Est3 protein is a subunit of yeast telomerase. Curr Biol 10(13):809-12	SGD

* Manually curated GO annotations reflect our best understanding of the basic molecular function, biological process, and cellular component for this gene product. Manually curated annotations are assigned by SGD curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all Manually curated GO annotations for accuracy and completeness. The "Last Reviewed on:" date at the top of this section indicates when these annotations were last reviewed.

There are no High-throughput annotations for TLC1

** GO annotations from High-throughput experiments are made based on a variety of large scale high-throughput experiments, including genome-wide experiments. Many of these annotations are made based on GO annotations (or mappings to GO annotations) assigned by the authors, rather than SGD curators. While SGD curators read these publications and often work closely with authors to incorporate the information, each individual annotation may not necessarily be reviewed by a curator. GO Annotations from high-throughput experiments will be assigned only when this type of data is available, and thus may not be assigned in all three aspects of the Gene Ontologies.

There are no Computational annotations for TLC1

*** Computational GO Annotations are predictions. These annotations are NOT reviewed by a curator. Currently, all computational GO annotations for S. cerevisiae are assigned by an external source (for example, the Gene Ontology Annotation (GOA) project of the European Bioinformatics Institute (EBI)).