This page displays GO annotations in different sections according to the annotation method used to add that annotation to SGD.

Last Reviewed on: 2006-08-23    Molecular Function | Biological Process | Cellular Component

Manually curated Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
base pairing with rRNA	IGI: Inferred from Genetic Interaction with SGD:RDN18-1, SGD:RDN18-2 Assigned on 2008-06-26 IMP: Inferred from Mutant Phenotype Assigned on 2008-06-26	Liang WQ and Fournier MJ  (1995) U14 base-pairs with 18S rRNA: a novel snoRNA interaction required for rRNA processing. Genes Dev 9(19):2433-43	SGD
rRNA 2'-O-ribose methylation guide activity	ISS: Inferred from Sequence or structural Similarity Assigned on 2006-04-07	Kiss-Laszlo Z, et al.  (1996) Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs. Cell 85(7):1077-88	SGD

Manually curated Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP: Inferred from Mutant Phenotype Assigned on 2008-06-26	Li HD, et al.  (1990) Depletion of U14 small nuclear RNA (snR128) disrupts production of 18S rRNA in Saccharomyces cerevisiae. Mol Cell Biol 10(3):1145-52	SGD
	IGI: Inferred from Genetic Interaction with SGD:RDN18-1, SGD:RDN18-2 Assigned on 2008-06-26 IMP: Inferred from Mutant Phenotype Assigned on 2008-06-26	Liang WQ and Fournier MJ  (1995) U14 base-pairs with 18S rRNA: a novel snoRNA interaction required for rRNA processing. Genes Dev 9(19):2433-43	SGD
rRNA methylation	ISS: Inferred from Sequence or structural Similarity Assigned on 2006-08-23	Kiss-Laszlo Z, et al.  (1996) Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs. Cell 85(7):1077-88	SGD

Manually curated Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
box C/D snoRNP complex	IPI: Inferred from Physical Interaction with SGD:NOP58, SGD:NOP56 Assigned on 2007-05-16	Lafontaine DL and Tollervey D  (2000) Synthesis and assembly of the box C+D small nucleolar RNPs. Mol Cell Biol 20(8):2650-9	SGD
	IDA: Inferred from Direct Assay Assigned on 2008-08-13	Lafontaine DL and Tollervey D  (1999) Nop58p is a common component of the box C+D snoRNPs that is required for snoRNA stability. RNA 5(3):455-67	SGD
	IPI: Inferred from Physical Interaction with SGD:NOP1, SGD:SNU13 Assigned on 2008-07-03	Watkins NJ, et al.  (2000) A common core RNP structure shared between the small nucleoar box C/D RNPs and the spliceosomal U4 snRNP. Cell 103(3):457-66	SGD
nucleolus	IDA: Inferred from Direct Assay Assigned on 2006-04-07	Zagorski J, et al.  (1988) Characterization of an SNR gene locus in Saccharomyces cerevisiae that specifies both dispensible and essential small nuclear RNAs. Mol Cell Biol 8(8):3282-90	SGD

* Manually curated GO annotations reflect our best understanding of the basic molecular function, biological process, and cellular component for this gene product. Manually curated annotations are assigned by SGD curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all Manually curated GO annotations for accuracy and completeness. The "Last Reviewed on:" date at the top of this section indicates when these annotations were last reviewed.

There are no High-throughput annotations for SNR128

** GO annotations from High-throughput experiments are made based on a variety of large scale high-throughput experiments, including genome-wide experiments. Many of these annotations are made based on GO annotations (or mappings to GO annotations) assigned by the authors, rather than SGD curators. While SGD curators read these publications and often work closely with authors to incorporate the information, each individual annotation may not necessarily be reviewed by a curator. GO Annotations from high-throughput experiments will be assigned only when this type of data is available, and thus may not be assigned in all three aspects of the Gene Ontologies.

There are no Computational annotations for SNR128

*** Computational GO Annotations are predictions. These annotations are NOT reviewed by a curator. Currently, all computational GO annotations for S. cerevisiae are assigned by an external source (for example, the Gene Ontology Annotation (GOA) project of the European Bioinformatics Institute (EBI)).