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This page displays GO annotations in different sections according to the annotation method used to add that annotation to SGD.

Last Reviewed on: 2003-12-19    Molecular Function | Biological Process

Manually curated Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
phosphoribosylaminoimidazole carboxylase activity	IMP: Inferred from Mutant Phenotype Assigned on 2009-04-17	Silver JM and Eaton NR  (1969) Functional blocks of the ad-1 and ad-2 mutants of Saccharomyces cerevisiae. Biochem Biophys Res Commun 34(3):301-5	SGD

Manually curated Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
'de novo' IMP biosynthetic process	TAS: Traceable Author Statement Assigned on 2005-04-28	Jones EW and Fink GR  (1982) "Regulation of amino acid and nucleotide biosynthesis in yeast." Pp.181-299 in The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, edited by Strathern JN, Jones EW and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press	SGD
purine base metabolic process	IMP: Inferred from Mutant Phenotype Assigned on 2002-10-01 TAS: Traceable Author Statement Assigned on 2002-10-01	Ugolini S and Bruschi CV  (1996) The red/white colony color assay in the yeast Saccharomyces cerevisiae: epistatic growth advantage of white ade8-18, ade2 cells over red ade2 cells. Curr Genet 30(6):485-92	SGD
purine nucleotide biosynthetic process	TAS: Traceable Author Statement Assigned on 2003-12-19	Jones EW and Fink GR  (1982) "Regulation of amino acid and nucleotide biosynthesis in yeast." Pp.181-299 in The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, edited by Strathern JN, Jones EW and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press	SGD

* Manually curated GO annotations reflect our best understanding of the basic molecular function, biological process, and cellular component for this gene product. Manually curated annotations are assigned by SGD curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all Manually curated GO annotations for accuracy and completeness. The "Last Reviewed on:" date at the top of this section indicates when these annotations were last reviewed.

Cellular Component

High-throughput Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
cytoplasm	IDA: Inferred from Direct Assay Assigned on 2003-10-28	Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91	SGD

** GO annotations from High-throughput experiments are made based on a variety of large scale high-throughput experiments, including genome-wide experiments. Many of these annotations are made based on GO annotations (or mappings to GO annotations) assigned by the authors, rather than SGD curators. While SGD curators read these publications and often work closely with authors to incorporate the information, each individual annotation may not necessarily be reviewed by a curator. GO Annotations from high-throughput experiments will be assigned only when this type of data is available, and thus may not be assigned in all three aspects of the Gene Ontologies.

Molecular Function | Biological Process

Computational Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
ATP binding	IEA: Inferred from Electronic Annotation with EBI:IPR016185, EBI:IPR011761, EBI:IPR013816, EBI:IPR013817 Last updated 2009-11-20	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:KW-0067 Last updated 2009-11-20	GOA curators  (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping.	UniProtKB
carboxy-lyase activity	IEA: Inferred from Electronic Annotation with EBI:KW-0210 Last updated 2009-11-20	GOA curators  (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping.	UniProtKB
catalytic activity	IEA: Inferred from Electronic Annotation with EBI:IPR016185, EBI:IPR011761, EBI:IPR013816, EBI:IPR013817 Last updated 2009-11-20	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	UniProtKB
lyase activity	IEA: Inferred from Electronic Annotation with EBI:KW-0456 Last updated 2009-11-20	GOA curators  (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping.	UniProtKB
nucleotide binding	IEA: Inferred from Electronic Annotation with EBI:KW-0547 Last updated 2009-11-20	GOA curators  (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping.	UniProtKB
phosphoribosylaminoimidazole carboxylase activity	IEA: Inferred from Electronic Annotation with EBI:IPR005875, EBI:IPR000031 Last updated 2009-11-20	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	UniProtKB
	IEA: Inferred from Electronic Annotation with IUBMB:4.1.1.21 Last updated 2009-11-20	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB

Computational Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
'de novo' IMP biosynthetic process	IEA: Inferred from Electronic Annotation with EBI:IPR005875, EBI:IPR000031 Last updated 2009-11-20	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	UniProtKB
purine nucleotide biosynthetic process	IEA: Inferred from Electronic Annotation with EBI:KW-0658 Last updated 2009-11-20	GOA curators  (2000) Gene Ontology annotation based on Swiss-Prot keyword mapping.	UniProtKB

*** Computational GO Annotations are predictions. These annotations are NOT reviewed by a curator. Currently, all computational GO annotations for S. cerevisiae are assigned by an external source (for example, the Gene Ontology Annotation (GOA) project of the European Bioinformatics Institute (EBI)).