This page displays GO annotations in different sections according to the annotation method used to add that annotation to SGD.

Last Reviewed on: 2003-06-02    Molecular Function | Biological Process | Cellular Component

Manually curated Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
protein binding	IPI: Inferred from Physical Interaction with SGD:TEM1, SGD:SNO4 Assigned on 2003-06-02	Uetz P, et al.  (2000) A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Nature 403(6770):623-7	SGD
	IPI: Inferred from Physical Interaction with SGD:SNZ1 Assigned on 2003-06-02	Padilla PA, et al.  (1998) The highly conserved, coregulated SNO and SNZ gene families in Saccharomyces cerevisiae respond to nutrient limitation. J Bacteriol 180(21):5718-26	SGD
	IPI: Inferred from Physical Interaction with SGD:THI11 Assigned on 2003-06-02	Rodriguez-Navarro S, et al.  (2002) Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6. Yeast 19(14):1261-76	SGD
	IPI: Inferred from Physical Interaction with SGD:SNZ3, SGD:SNO2, SGD:SNZ2, SGD:SNO1 Assigned on 2003-06-02	Ito T, et al.  (2000) Toward a protein-protein interaction map of the budding yeast: A comprehensive system to examine two-hybrid interactions in all possible combinations between the yeast proteins. Proc Natl Acad Sci U S A 97(3):1143-7	SGD

Manually curated Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
pyridoxine metabolic process	IDA: Inferred from Direct Assay Assigned on 2002-05-24	Padilla PA, et al.  (1998) The highly conserved, coregulated SNO and SNZ gene families in Saccharomyces cerevisiae respond to nutrient limitation. J Bacteriol 180(21):5718-26	SGD
	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-05-24	Osmani AH, et al.  (1999) The extremely conserved pyroA gene of Aspergillus nidulans is required for pyridoxine synthesis and is required indirectly for resistance to photosensitizers. J Biol Chem 274(33):23565-9	SGD
	ISS: Inferred from Sequence or structural Similarity Assigned on 2002-05-24	Bean LE, et al.  (2001) Analysis of the pdx-1 (snz-1/sno-1) region of the Neurospora crassa genome: correlation of pyridoxine-requiring phenotypes with mutations in two structural genes. Genetics 157(3):1067-75	SGD
thiamine biosynthetic process	IMP: Inferred from Mutant Phenotype Assigned on 2002-12-05	Rodriguez-Navarro S, et al.  (2002) Functional analysis of yeast gene families involved in metabolism of vitamins B1 and B6. Yeast 19(14):1261-76	SGD

Manually curated Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
cellular_component unknown	ND: No Biological Data Available Assigned on 2003-06-02	SGD  (2002) Use of the ND evidence code for Gene Ontology (GO) terms in SGD ()	SGD

* Manually curated GO annotations reflect our best understanding of the basic molecular function, biological process, and cellular component for this gene product. Manually curated annotations are assigned by SGD curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all Manually curated GO annotations for accuracy and completeness. The "Last Reviewed on:" date at the top of this section indicates when these annotations were last reviewed.

There are no High-throughput annotations for SNZ2

** GO annotations from High-throughput experiments are made based on a variety of large scale high-throughput experiments, including genome-wide experiments. Many of these annotations are made based on GO annotations (or mappings to GO annotations) assigned by the authors, rather than SGD curators. While SGD curators read these publications and often work closely with authors to incorporate the information, each individual annotation may not necessarily be reviewed by a curator. GO Annotations from high-throughput experiments will be assigned only when this type of data is available, and thus may not be assigned in all three aspects of the Gene Ontologies.

Molecular Function | Biological Process

Computational Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
catalytic activity	IEA: Inferred from Electronic Annotation with EBI:IPR013785, EBI:IPR011060 Last updated 2013-03-02	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro

Computational Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
metabolic process	IEA: Inferred from Electronic Annotation with EBI:IPR011060 Last updated 2013-03-02	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
pyridoxal phosphate biosynthetic process	IEA: Inferred from Electronic Annotation with EBI:IPR001852 Last updated 2013-03-02	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
pyridoxine biosynthetic process	IEA: Inferred from Electronic Annotation with EBI:KW-0664 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB

*** Computational GO Annotations are predictions. These annotations are NOT reviewed by a curator. Currently, all computational GO annotations for S. cerevisiae are assigned by an external source (for example, the Gene Ontology Annotation (GOA) project of the European Bioinformatics Institute (EBI)).