This page displays GO annotations in different sections according to the annotation method used to add that annotation to SGD.

Last Reviewed on: 2003-08-14    Molecular Function | Biological Process | Cellular Component

Manually curated Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
protein phosphatase type 2A regulator activity	IGI: Inferred from Genetic Interaction with SGD:CDC55 Assigned on 2008-10-29 IMP: Inferred from Mutant Phenotype Assigned on 2008-10-29	Queralt E and Uhlmann F  (2008) Separase cooperates with Zds1 and Zds2 to activate Cdc14 phosphatase in early anaphase. J Cell Biol 182(5):873-83	SGD

Manually curated Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
cell aging	IMP: Inferred from Mutant Phenotype Assigned on 2003-08-14	Roy N and Runge KW  (2000) Two paralogs involved in transcriptional silencing that antagonistically control yeast life span. Curr Biol 10(2):111-4	SGD
cell shape checkpoint	IGI: Inferred from Genetic Interaction with SGD:CDC55, SGD:ZDS2 Assigned on 2010-11-19	Yasutis K, et al.  (2010) Zds2p Regulates Swe1p-dependent Polarized Cell Growth in Saccharomyces cerevisiae via a Novel Cdc55p Interaction Domain. Mol Biol Cell 21(24):4373-86	SGD
chromatin silencing	IMP: Inferred from Mutant Phenotype Assigned on 2002-11-14	Roy N and Runge KW  (2000) Two paralogs involved in transcriptional silencing that antagonistically control yeast life span. Curr Biol 10(2):111-4	SGD
establishment of cell polarity	IGI: Inferred from Genetic Interaction with SGD:CDC24, SGD:CDC42, SGD:ZDS2 Assigned on 2010-01-06 IMP: Inferred from Mutant Phenotype Assigned on 2010-01-06	Bi E and Pringle JR  (1996) ZDS1 and ZDS2, genes whose products may regulate Cdc42p in Saccharomyces cerevisiae. Mol Cell Biol 16(10):5264-75	SGD
mRNA export from nucleus	IGI: Inferred from Genetic Interaction with SGD:GFD1, SGD:DBP5 Assigned on 2005-01-05 IMP: Inferred from Mutant Phenotype Assigned on 2005-01-05 IPI: Inferred from Physical Interaction with SGD:GFD1, SGD:DBP5 Assigned on 2005-01-05	Estruch F, et al.  (2005) Physical and genetic interactions link the yeast protein Zds1p with mRNA nuclear export. J Biol Chem 280(10):9691-7	SGD
positive regulation of G2/M transition of mitotic cell cycle	IMP: Inferred from Mutant Phenotype Assigned on 2012-01-25	Rossio V and Yoshida S  (2011) Spatial regulation of Cdc55-PP2A by Zds1/Zds2 controls mitotic entry and mitotic exit in budding yeast. J Cell Biol 193(3):445-54	SGD
regulation of protein localization	IMP: Inferred from Mutant Phenotype Assigned on 2008-10-29	Queralt E and Uhlmann F  (2008) Separase cooperates with Zds1 and Zds2 to activate Cdc14 phosphatase in early anaphase. J Cell Biol 182(5):873-83	SGD

Manually curated Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
cellular bud neck	IDA: Inferred from Direct Assay Assigned on 2012-01-25	Rossio V and Yoshida S  (2011) Spatial regulation of Cdc55-PP2A by Zds1/Zds2 controls mitotic entry and mitotic exit in budding yeast. J Cell Biol 193(3):445-54	SGD
cellular bud tip	IDA: Inferred from Direct Assay Assigned on 2002-11-14	Bi E and Pringle JR  (1996) ZDS1 and ZDS2, genes whose products may regulate Cdc42p in Saccharomyces cerevisiae. Mol Cell Biol 16(10):5264-75	SGD
cytoplasm	IDA: Inferred from Direct Assay Assigned on 2012-01-25	Rossio V and Yoshida S  (2011) Spatial regulation of Cdc55-PP2A by Zds1/Zds2 controls mitotic entry and mitotic exit in budding yeast. J Cell Biol 193(3):445-54	SGD
	IPI: Inferred from Physical Interaction Assigned on 2002-11-14	Griffioen G, et al.  (2001) Nucleocytoplasmic distribution of budding yeast protein kinase A regulatory subunit Bcy1 requires Zds1 and is regulated by Yak1-dependent phosphorylation of its targeting domain. Mol Cell Biol 21(2):511-23	SGD
incipient cellular bud site	IDA: Inferred from Direct Assay Assigned on 2010-01-06	Bi E and Pringle JR  (1996) ZDS1 and ZDS2, genes whose products may regulate Cdc42p in Saccharomyces cerevisiae. Mol Cell Biol 16(10):5264-75	SGD
nuclear pore	IPI: Inferred from Physical Interaction with SGD:GFD1, SGD:DBP5 Assigned on 2005-01-05	Estruch F, et al.  (2005) Physical and genetic interactions link the yeast protein Zds1p with mRNA nuclear export. J Biol Chem 280(10):9691-7	SGD

* Manually curated GO annotations reflect our best understanding of the basic molecular function, biological process, and cellular component for this gene product. Manually curated annotations are assigned by SGD curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all Manually curated GO annotations for accuracy and completeness. The "Last Reviewed on:" date at the top of this section indicates when these annotations were last reviewed.

There are no High-throughput annotations for ZDS1

** GO annotations from High-throughput experiments are made based on a variety of large scale high-throughput experiments, including genome-wide experiments. Many of these annotations are made based on GO annotations (or mappings to GO annotations) assigned by the authors, rather than SGD curators. While SGD curators read these publications and often work closely with authors to incorporate the information, each individual annotation may not necessarily be reviewed by a curator. GO Annotations from high-throughput experiments will be assigned only when this type of data is available, and thus may not be assigned in all three aspects of the Gene Ontologies.

Biological Process | Cellular Component

Computational Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
mRNA transport	IEA: Inferred from Electronic Annotation with EBI:KW-0509 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
transport	IEA: Inferred from Electronic Annotation with EBI:KW-0813 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB

Computational Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
cytoplasm	IEA: Inferred from Electronic Annotation with EBI:SL-0086 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:KW-0963 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB

*** Computational GO Annotations are predictions. These annotations are NOT reviewed by a curator. Currently, all computational GO annotations for S. cerevisiae are assigned by an external source (for example, the Gene Ontology Annotation (GOA) project of the European Bioinformatics Institute (EBI)).