This page displays GO annotations in different sections according to the annotation method used to add that annotation to SGD.

Last Reviewed on: 2007-10-12    Molecular Function | Biological Process | Cellular Component

Manually curated Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
phosphoglucomutase activity	IMP: Inferred from Mutant Phenotype Assigned on 2007-10-09	Oh D and Hopper JE  (1990) Transcription of a yeast phosphoglucomutase isozyme gene is galactose inducible and glucose repressible. Mol Cell Biol 10(4):1415-22	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2007-10-05	DOUGLAS HC  (1961) A mutation in saccharomyces that affects phosphoglucomutase activity and galactose utilization. Biochim Biophys Acta 52:209-11	SGD
	IGI: Inferred from Genetic Interaction with SGD:PGM1 Assigned on 2007-10-09 ISS: Inferred from Sequence or structural Similarity with EBI:P36871 Assigned on 2007-10-09 IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	Boles E, et al.  (1994) A family of hexosephosphate mutases in Saccharomyces cerevisiae. Eur J Biochem 220(1):83-96	SGD

Manually curated Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
cellular calcium ion homeostasis	IGI: Inferred from Genetic Interaction with SGD:PMC1 Assigned on 2007-10-09 IMP: Inferred from Mutant Phenotype Assigned on 2007-10-09	Aiello DP, et al.  (2004) The Ca2+ homeostasis defects in a pgm2Delta strain of Saccharomyces cerevisiae are caused by excessive vacuolar Ca2+ uptake mediated by the Ca2+-ATPase Pmc1p. J Biol Chem 279(37):38495-502	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2007-10-09	Fu L, et al.  (2000) Loss of the major isoform of phosphoglucomutase results in altered calcium homeostasis in Saccharomyces cerevisiae. J Biol Chem 275(8):5431-40	SGD
cellular cation homeostasis	IMP: Inferred from Mutant Phenotype Assigned on 2007-10-09	Mulet JM, et al.  (2004) The trehalose pathway and intracellular glucose phosphates as modulators of potassium transport and general cation homeostasis in yeast. Yeast 21(7):569-82	SGD
galactose catabolic process	IMP: Inferred from Mutant Phenotype Assigned on 2007-10-09	DOUGLAS HC  (1961) A mutation in saccharomyces that affects phosphoglucomutase activity and galactose utilization. Biochim Biophys Acta 52:209-11	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2007-10-11	TSOI A and DOUGLAS HC  (1964) THE EFFECT OF MUTATION OF TWO FORMS OF PHOSPHOGLUCOMUTASE IN SACCHAROMYCES. Biochim Biophys Acta 92:513-20	SGD
	IGI: Inferred from Genetic Interaction with SGD:PGM1 Assigned on 2007-10-12 IMP: Inferred from Mutant Phenotype Assigned on 2007-10-12	Boles E, et al.  (1994) A family of hexosephosphate mutases in Saccharomyces cerevisiae. Eur J Biochem 220(1):83-96	SGD
glucose 1-phosphate metabolic process	IMP: Inferred from Mutant Phenotype Assigned on 2007-10-11	Fu L, et al.  (2000) Loss of the major isoform of phosphoglucomutase results in altered calcium homeostasis in Saccharomyces cerevisiae. J Biol Chem 275(8):5431-40	SGD
	IGI: Inferred from Genetic Interaction with SGD:PGM1 Assigned on 2007-10-11 ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18 IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	Boles E, et al.  (1994) A family of hexosephosphate mutases in Saccharomyces cerevisiae. Eur J Biochem 220(1):83-96	SGD
glucose 6-phosphate metabolic process	ISS: Inferred from Sequence or structural Similarity Assigned on 2001-01-18	Boles E, et al.  (1994) A family of hexosephosphate mutases in Saccharomyces cerevisiae. Eur J Biochem 220(1):83-96	SGD
glycogen biosynthetic process	IGI: Inferred from Genetic Interaction with SGD:UGP1, SGD:PGM1 Assigned on 2007-10-12	Daran JM, et al.  (1997) Physiological and morphological effects of genetic alterations leading to a reduced synthesis of UDP-glucose in Saccharomyces cerevisiae. FEMS Microbiol Lett 153(1):89-96	SGD
trehalose biosynthetic process	IGI: Inferred from Genetic Interaction with SGD:PGM1 Assigned on 2007-10-12	Daran JM, et al.  (1997) Physiological and morphological effects of genetic alterations leading to a reduced synthesis of UDP-glucose in Saccharomyces cerevisiae. FEMS Microbiol Lett 153(1):89-96	SGD
UDP-glucose metabolic process	IGI: Inferred from Genetic Interaction with SGD:PGM1 Assigned on 2007-10-12	Daran JM, et al.  (1997) Physiological and morphological effects of genetic alterations leading to a reduced synthesis of UDP-glucose in Saccharomyces cerevisiae. FEMS Microbiol Lett 153(1):89-96	SGD

Manually curated Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
cytoplasm	IDA: Inferred from Direct Assay Assigned on 2007-10-05	Marchase RB, et al.  (1993) Phosphoglucomutase in Saccharomyces cerevisiae is a cytoplasmic glycoprotein and the acceptor for a Glc-phosphotransferase. J Biol Chem 268(11):8341-9	SGD

* Manually curated GO annotations reflect our best understanding of the basic molecular function, biological process, and cellular component for this gene product. Manually curated annotations are assigned by SGD curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all Manually curated GO annotations for accuracy and completeness. The "Last Reviewed on:" date at the top of this section indicates when these annotations were last reviewed.

There are no High-throughput annotations for PGM2

** GO annotations from High-throughput experiments are made based on a variety of large scale high-throughput experiments, including genome-wide experiments. Many of these annotations are made based on GO annotations (or mappings to GO annotations) assigned by the authors, rather than SGD curators. While SGD curators read these publications and often work closely with authors to incorporate the information, each individual annotation may not necessarily be reviewed by a curator. GO Annotations from high-throughput experiments will be assigned only when this type of data is available, and thus may not be assigned in all three aspects of the Gene Ontologies.

Molecular Function | Biological Process | Cellular Component

Computational Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
intramolecular transferase activity, phosphotransferases	IEA: Inferred from Electronic Annotation with EBI:IPR005846, EBI:IPR005843, EBI:IPR005845, EBI:IPR016055, EBI:IPR005841, EBI:IPR005844 Last updated 2013-03-02	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
isomerase activity	IEA: Inferred from Electronic Annotation with EBI:KW-0413 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
magnesium ion binding	IEA: Inferred from Electronic Annotation with EBI:IPR016066 Last updated 2013-03-02	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
metal ion binding	IEA: Inferred from Electronic Annotation with EBI:KW-0479 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
phosphoglucomutase activity	IEA: Inferred from Electronic Annotation with IUBMB:5.4.2.2 Last updated 2013-03-02	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB

Computational Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
carbohydrate metabolic process	IEA: Inferred from Electronic Annotation with EBI:IPR005846, EBI:IPR005843, EBI:IPR005845, EBI:IPR016055, EBI:IPR005841, EBI:IPR005844 Last updated 2013-03-02	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0119 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
glucose metabolic process	IEA: Inferred from Electronic Annotation with EBI:KW-0313 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB

Computational Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
cytoplasm	IEA: Inferred from Electronic Annotation with EBI:SL-0086 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:KW-0963 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
cytosol	IBA: Inferred from Biological Aspect of Ancestor with PANTHER:PTHR22573_AN0 Last updated 2011-10-06	Gaudet P, et al.  (2011) Annotation inferences using phylogenetic trees.	RefGenome

*** Computational GO Annotations are predictions. These annotations are NOT reviewed by a curator. Currently, all computational GO annotations for S. cerevisiae are assigned by an external source (for example, the Gene Ontology Annotation (GOA) project of the European Bioinformatics Institute (EBI)).