This page displays GO annotations in different sections according to the annotation method used to add that annotation to SGD.

Last Reviewed on: 2002-12-06    Molecular Function | Biological Process | Cellular Component

Manually curated Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
GTPase activity	IDA: Inferred from Direct Assay Assigned on 2009-11-13	Roumanie O, et al.  (2001) Functional characterization of the Bag7, Lrg1 and Rgd2 RhoGAP proteins from Saccharomyces cerevisiae. FEBS Lett 506(2):149-56	SGD
signal transducer activity	TAS: Traceable Author Statement Assigned on 2001-01-18	Madden K and Snyder M  (1998) Cell polarity and morphogenesis in budding yeast. Annu Rev Microbiol 52():687-744	SGD

Manually curated Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
budding cell apical bud growth	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	Johnson DI  (1999) Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity. Microbiol Mol Biol Rev 63(1):54-105	SGD
budding cell isotropic bud growth	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	Johnson DI  (1999) Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity. Microbiol Mol Biol Rev 63(1):54-105	SGD
establishment of cell polarity	IMP: Inferred from Mutant Phenotype Assigned on 2013-04-25	Meitinger F, et al.  (2013) A safeguard mechanism regulates Rho GTPases to coordinate cytokinesis with the establishment of cell polarity. PLoS Biol 11(2):e1001495	SGD
invasive growth in response to glucose limitation	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	Johnson DI  (1999) Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity. Microbiol Mol Biol Rev 63(1):54-105	SGD
pheromone-dependent signal transduction involved in conjugation with cellular fusion	IGI: Inferred from Genetic Interaction Assigned on 2002-12-06 IMP: Inferred from Mutant Phenotype Assigned on 2002-12-06	Moskow JJ, et al.  (2000) Role of Cdc42p in pheromone-stimulated signal transduction in Saccharomyces cerevisiae. Mol Cell Biol 20(20):7559-71	SGD
positive regulation of exocytosis	IMP: Inferred from Mutant Phenotype Assigned on 2013-01-18	Zhang X, et al.  (2001) Cdc42 interacts with the exocyst and regulates polarized secretion. J Biol Chem 276(50):46745-50	SGD
	IGI: Inferred from Genetic Interaction with SGD:EXO70 Assigned on 2010-03-15 IPI: Inferred from Physical Interaction with SGD:EXO70 Assigned on 2010-03-15	Wu H, et al.  (2010) The exo70 subunit of the exocyst is an effector for both cdc42 and rho3 function in polarized exocytosis. Mol Biol Cell 21(3):430-42	SGD
pseudohyphal growth	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	Johnson DI  (1999) Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity. Microbiol Mol Biol Rev 63(1):54-105	SGD
regulation of exit from mitosis	IMP: Inferred from Mutant Phenotype Assigned on 2005-03-24	Hofken T and Schiebel E  (2002) A role for cell polarity proteins in mitotic exit. EMBO J 21(18):4851-62	SGD
regulation of exocyst localization	IMP: Inferred from Mutant Phenotype Assigned on 2013-01-18	Zhang X, et al.  (2001) Cdc42 interacts with the exocyst and regulates polarized secretion. J Biol Chem 276(50):46745-50	SGD
regulation of initiation of mating projection growth	IMP: Inferred from Mutant Phenotype Assigned on 2005-07-19	Bidlingmaier S and Snyder M  (2004) Regulation of polarized growth initiation and termination cycles by the polarisome and Cdc42 regulators. J Cell Biol 164(2):207-18	SGD
regulation of vacuole fusion, non-autophagic	IMP: Inferred from Mutant Phenotype Assigned on 2009-11-13	Eitzen G, et al.  (2001) Rho1p and Cdc42p act after Ypt7p to regulate vacuole docking. EMBO J 20(20):5650-6	SGD
Rho protein signal transduction	TAS: Traceable Author Statement Assigned on 2001-01-18	Madden K and Snyder M  (1998) Cell polarity and morphogenesis in budding yeast. Annu Rev Microbiol 52():687-744	SGD

Manually curated Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
cellular bud neck	IDA: Inferred from Direct Assay Assigned on 2012-08-13	Richman TJ, et al.  (2002) Saccharomyces cerevisiae Cdc42p localizes to cellular membranes and clusters at sites of polarized growth. Eukaryot Cell 1(3):458-68	SGD
cellular bud tip	IDA: Inferred from Direct Assay Assigned on 2012-08-13	Ziman M, et al.  (1993) Subcellular localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding protein involved in the control of cell polarity. Mol Biol Cell 4(12):1307-16	SGD
	IDA: Inferred from Direct Assay Assigned on 2012-08-13	Richman TJ, et al.  (2002) Saccharomyces cerevisiae Cdc42p localizes to cellular membranes and clusters at sites of polarized growth. Eukaryot Cell 1(3):458-68	SGD
fungal-type vacuole membrane	IDA: Inferred from Direct Assay Assigned on 2012-08-13	Richman TJ, et al.  (2002) Saccharomyces cerevisiae Cdc42p localizes to cellular membranes and clusters at sites of polarized growth. Eukaryot Cell 1(3):458-68	SGD
incipient cellular bud site	IDA: Inferred from Direct Assay Assigned on 2012-08-13	Ziman M, et al.  (1993) Subcellular localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding protein involved in the control of cell polarity. Mol Biol Cell 4(12):1307-16	SGD
	IDA: Inferred from Direct Assay Assigned on 2012-08-13	Richman TJ, et al.  (2002) Saccharomyces cerevisiae Cdc42p localizes to cellular membranes and clusters at sites of polarized growth. Eukaryot Cell 1(3):458-68	SGD
mating projection tip	IDA: Inferred from Direct Assay Assigned on 2012-08-13	Ziman M, et al.  (1993) Subcellular localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding protein involved in the control of cell polarity. Mol Biol Cell 4(12):1307-16	SGD
nuclear membrane	IDA: Inferred from Direct Assay Assigned on 2012-08-13	Richman TJ, et al.  (2002) Saccharomyces cerevisiae Cdc42p localizes to cellular membranes and clusters at sites of polarized growth. Eukaryot Cell 1(3):458-68	SGD
plasma membrane	IDA: Inferred from Direct Assay Assigned on 2012-08-13	Ziman M, et al.  (1993) Subcellular localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding protein involved in the control of cell polarity. Mol Biol Cell 4(12):1307-16	SGD
	IDA: Inferred from Direct Assay Assigned on 2012-08-13	Richman TJ, et al.  (2002) Saccharomyces cerevisiae Cdc42p localizes to cellular membranes and clusters at sites of polarized growth. Eukaryot Cell 1(3):458-68	SGD

* Manually curated GO annotations reflect our best understanding of the basic molecular function, biological process, and cellular component for this gene product. Manually curated annotations are assigned by SGD curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all Manually curated GO annotations for accuracy and completeness. The "Last Reviewed on:" date at the top of this section indicates when these annotations were last reviewed.

There are no High-throughput annotations for CDC42

** GO annotations from High-throughput experiments are made based on a variety of large scale high-throughput experiments, including genome-wide experiments. Many of these annotations are made based on GO annotations (or mappings to GO annotations) assigned by the authors, rather than SGD curators. While SGD curators read these publications and often work closely with authors to incorporate the information, each individual annotation may not necessarily be reviewed by a curator. GO Annotations from high-throughput experiments will be assigned only when this type of data is available, and thus may not be assigned in all three aspects of the Gene Ontologies.

Molecular Function | Biological Process | Cellular Component

Computational Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
GTP binding	IEA: Inferred from Electronic Annotation with EBI:IPR001806, EBI:IPR005225, EBI:IPR003578 Last updated 2013-03-02	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0342 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
nucleotide binding	IEA: Inferred from Electronic Annotation with EBI:KW-0547 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB

Computational Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
cell cycle	IEA: Inferred from Electronic Annotation with EBI:KW-0131 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
cell division	IEA: Inferred from Electronic Annotation with EBI:KW-0132 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
response to pheromone	IEA: Inferred from Electronic Annotation with EBI:KW-0589 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
small GTPase mediated signal transduction	IEA: Inferred from Electronic Annotation with EBI:IPR001806, EBI:IPR003578 Last updated 2013-03-02	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro

Computational Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
intracellular	IEA: Inferred from Electronic Annotation with EBI:IPR003578 Last updated 2013-03-02	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
membrane	IEA: Inferred from Electronic Annotation with EBI:KW-0472 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
plasma membrane	IEA: Inferred from Electronic Annotation with EBI:SL-0039 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:KW-1003 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB

*** Computational GO Annotations are predictions. These annotations are NOT reviewed by a curator. Currently, all computational GO annotations for S. cerevisiae are assigned by an external source (for example, the Gene Ontology Annotation (GOA) project of the European Bioinformatics Institute (EBI)).