This page displays GO annotations in different sections according to the annotation method used to add that annotation to SGD.

Last Reviewed on: 2003-06-19    Molecular Function | Biological Process | Cellular Component

Manually curated Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
cyclin-dependent protein serine/threonine kinase inhibitor activity	IDA: Inferred from Direct Assay Assigned on 2007-03-02 IPI: Inferred from Physical Interaction with SGD:CDC28 Assigned on 2007-03-02	Mendenhall MD  (1993) An inhibitor of p34CDC28 protein kinase activity from Saccharomyces cerevisiae. Science 259(5092):216-9	SGD
	IDA: Inferred from Direct Assay Assigned on 2007-03-02	Schwob E, et al.  (1994) The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79(2):233-44	SGD

Manually curated Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
G1/S transition of mitotic cell cycle	IGI: Inferred from Genetic Interaction with SGD:CDC34, SGD:CLB5, SGD:CDC4, SGD:CDC53 Assigned on 2007-08-09 IEP: Inferred from Expression Pattern Assigned on 2007-08-09	Schwob E, et al.  (1994) The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79(2):233-44	SGD
negative regulation of macroautophagy	IMP: Inferred from Mutant Phenotype Assigned on 2010-05-10	Yang Z, et al.  (2010) Positive or negative roles of different cyclin-dependent kinase Pho85-cyclin complexes orchestrate induction of autophagy in Saccharomyces cerevisiae. Mol Cell 38(2):250-64	SGD
regulation of cyclin-dependent protein serine/threonine kinase activity	IEP: Inferred from Expression Pattern Assigned on 2002-03-21 IMP: Inferred from Mutant Phenotype Assigned on 2002-03-21 IDA: Inferred from Direct Assay Assigned on 2002-03-21 IPI: Inferred from Physical Interaction Assigned on 2002-03-21	Schwob E, et al.  (1994) The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae. Cell 79(2):233-44	SGD

Manually curated Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
cytoplasm	IDA: Inferred from Direct Assay Assigned on 2002-05-28	Edgington NP and Futcher B  (2001) Relationship between the function and the location of G1 cyclins in S. cerevisiae. J Cell Sci 114(Pt 24):4599-611	SGD
nucleus	IDA: Inferred from Direct Assay Assigned on 2002-05-28	Edgington NP and Futcher B  (2001) Relationship between the function and the location of G1 cyclins in S. cerevisiae. J Cell Sci 114(Pt 24):4599-611	SGD
	IDA: Inferred from Direct Assay Assigned on 2003-06-19	Blondel M, et al.  (2000) Nuclear-specific degradation of Far1 is controlled by the localization of the F-box protein Cdc4. EMBO J 19(22):6085-97	SGD

* Manually curated GO annotations reflect our best understanding of the basic molecular function, biological process, and cellular component for this gene product. Manually curated annotations are assigned by SGD curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all Manually curated GO annotations for accuracy and completeness. The "Last Reviewed on:" date at the top of this section indicates when these annotations were last reviewed.

There are no High-throughput annotations for SIC1

** GO annotations from High-throughput experiments are made based on a variety of large scale high-throughput experiments, including genome-wide experiments. Many of these annotations are made based on GO annotations (or mappings to GO annotations) assigned by the authors, rather than SGD curators. While SGD curators read these publications and often work closely with authors to incorporate the information, each individual annotation may not necessarily be reviewed by a curator. GO Annotations from high-throughput experiments will be assigned only when this type of data is available, and thus may not be assigned in all three aspects of the Gene Ontologies.

Cellular Component

Computational Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
cytoplasm	IEA: Inferred from Electronic Annotation with EBI:SL-0086 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:KW-0963 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
nucleus	IEA: Inferred from Electronic Annotation with EBI:SL-0191 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:KW-0539 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB

*** Computational GO Annotations are predictions. These annotations are NOT reviewed by a curator. Currently, all computational GO annotations for S. cerevisiae are assigned by an external source (for example, the Gene Ontology Annotation (GOA) project of the European Bioinformatics Institute (EBI)).