This page displays GO annotations in different sections according to the annotation method used to add that annotation to SGD.

Last Reviewed on: 2003-03-25    Molecular Function | Biological Process | Cellular Component

Manually curated Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
molecular_function unknown	ND: No Biological Data Available Assigned on 2002-11-25	SGD  (2002) Use of the ND evidence code for Gene Ontology (GO) terms in SGD ()	SGD

Manually curated Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
chromatin silencing at telomere	IMP: Inferred from Mutant Phenotype Assigned on 2012-12-11	Ghosh S, et al.  (2012) Acetylation of the SUN protein Mps3 by Eco1 regulates its function in nuclear organization. Mol Biol Cell 23(13):2546-59	SGD
establishment of mitotic sister chromatid cohesion	IMP: Inferred from Mutant Phenotype Assigned on 2012-12-11	Ghosh S, et al.  (2012) Acetylation of the SUN protein Mps3 by Eco1 regulates its function in nuclear organization. Mol Biol Cell 23(13):2546-59	SGD
meiotic telomere clustering	IGI: Inferred from Genetic Interaction with SGD:REC8 Assigned on 2008-08-01 IMP: Inferred from Mutant Phenotype Assigned on 2008-08-01	Conrad MN, et al.  (2007) MPS3 mediates meiotic bouquet formation in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 104(21):8863-8	SGD
mitotic sister chromatid cohesion	IMP: Inferred from Mutant Phenotype Assigned on 2005-01-19	Antoniacci LM, et al.  (2004) The spindle pole body assembly component mps3p/nep98p functions in sister chromatid cohesion. J Biol Chem 279(47):49542-50	SGD
nuclear migration involved in conjugation with cellular fusion	IMP: Inferred from Mutant Phenotype Assigned on 2003-03-25	Nishikawa S, et al.  (2003) Nep98p is a component of the yeast spindle pole body and essential for nuclear division and fusion. J Biol Chem 278(11):9938-43	SGD
spindle pole body duplication associated with nuclear envelope	IMP: Inferred from Mutant Phenotype Assigned on 2002-12-28	Jaspersen SL, et al.  (2002) Mps3p is a novel component of the yeast spindle pole body that interacts with the yeast centrin homologue Cdc31p. J Cell Biol 159(6):945-56	SGD
synapsis	IGI: Inferred from Genetic Interaction with SGD:NDJ1 Assigned on 2008-08-01 IMP: Inferred from Mutant Phenotype Assigned on 2008-08-01	Conrad MN, et al.  (2007) MPS3 mediates meiotic bouquet formation in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 104(21):8863-8	SGD
telomere tethering at nuclear periphery	IMP: Inferred from Mutant Phenotype Assigned on 2008-04-14	Bupp JM, et al.  (2007) Telomere anchoring at the nuclear periphery requires the budding yeast Sad1-UNC-84 domain protein Mps3. J Cell Biol 179(5):845-54	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2012-12-11	Ghosh S, et al.  (2012) Acetylation of the SUN protein Mps3 by Eco1 regulates its function in nuclear organization. Mol Biol Cell 23(13):2546-59	SGD

Manually curated Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
half bridge of spindle pole body	IDA: Inferred from Direct Assay Assigned on 2004-10-08	Jaspersen SL, et al.  (2002) Mps3p is a novel component of the yeast spindle pole body that interacts with the yeast centrin homologue Cdc31p. J Cell Biol 159(6):945-56	SGD
integral to membrane	IDA: Inferred from Direct Assay Assigned on 2004-10-08	Jaspersen SL, et al.  (2002) Mps3p is a novel component of the yeast spindle pole body that interacts with the yeast centrin homologue Cdc31p. J Cell Biol 159(6):945-56	SGD
	IDA: Inferred from Direct Assay Assigned on 2003-03-25	Nishikawa S, et al.  (2003) Nep98p is a component of the yeast spindle pole body and essential for nuclear division and fusion. J Biol Chem 278(11):9938-43	SGD
nuclear chromosome, telomeric region	IDA: Inferred from Direct Assay Assigned on 2008-08-01	Conrad MN, et al.  (2007) MPS3 mediates meiotic bouquet formation in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 104(21):8863-8	SGD
nuclear envelope	IDA: Inferred from Direct Assay Assigned on 2008-08-01	Conrad MN, et al.  (2007) MPS3 mediates meiotic bouquet formation in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 104(21):8863-8	SGD
nuclear periphery	IDA: Inferred from Direct Assay Assigned on 2008-04-14	Bupp JM, et al.  (2007) Telomere anchoring at the nuclear periphery requires the budding yeast Sad1-UNC-84 domain protein Mps3. J Cell Biol 179(5):845-54	SGD

* Manually curated GO annotations reflect our best understanding of the basic molecular function, biological process, and cellular component for this gene product. Manually curated annotations are assigned by SGD curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all Manually curated GO annotations for accuracy and completeness. The "Last Reviewed on:" date at the top of this section indicates when these annotations were last reviewed.

There are no High-throughput annotations for MPS3

** GO annotations from High-throughput experiments are made based on a variety of large scale high-throughput experiments, including genome-wide experiments. Many of these annotations are made based on GO annotations (or mappings to GO annotations) assigned by the authors, rather than SGD curators. While SGD curators read these publications and often work closely with authors to incorporate the information, each individual annotation may not necessarily be reviewed by a curator. GO Annotations from high-throughput experiments will be assigned only when this type of data is available, and thus may not be assigned in all three aspects of the Gene Ontologies.

Molecular Function | Biological Process | Cellular Component

Computational Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
ATP binding	IEA: Inferred from Electronic Annotation with EBI:KW-0067 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
nucleotide binding	IEA: Inferred from Electronic Annotation with EBI:KW-0547 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB

Computational Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
cell cycle	IEA: Inferred from Electronic Annotation with EBI:KW-0131 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB

Computational Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
cytoplasm	IEA: Inferred from Electronic Annotation with EBI:KW-0963 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
cytoskeleton	IEA: Inferred from Electronic Annotation with EBI:KW-0206 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
integral to membrane	IEA: Inferred from Electronic Annotation with EBI:KW-0812 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
membrane	IEA: Inferred from Electronic Annotation with EBI:KW-0472 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
nuclear membrane	IEA: Inferred from Electronic Annotation with EBI:SL-0182 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
nucleus	IEA: Inferred from Electronic Annotation with EBI:KW-0539 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
spindle pole body	IEA: Inferred from Electronic Annotation with EBI:SL-0252 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB

*** Computational GO Annotations are predictions. These annotations are NOT reviewed by a curator. Currently, all computational GO annotations for S. cerevisiae are assigned by an external source (for example, the Gene Ontology Annotation (GOA) project of the European Bioinformatics Institute (EBI)).