This page displays GO annotations in different sections according to the annotation method used to add that annotation to SGD.

Last Reviewed on: 2003-10-28    Molecular Function | Biological Process

Manually curated Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
alditol:NADP+ 1-oxidoreductase activity	ISS: Inferred from Sequence or structural Similarity with EBI:P15121 Assigned on 2008-08-01 IDA: Inferred from Direct Assay Assigned on 2003-09-12	Petrash JM, et al.  (2001) Functional genomic studies of aldo-keto reductases. Chem Biol Interact 130-132(1-3):673-83	SGD
carbonyl reductase (NADPH) activity	IDA: Inferred from Direct Assay Assigned on 2008-12-02	Hwang JY, et al.  (2009) Simultaneous synthesis of 2-phenylethanol and L-homophenylalanine using aromatic transaminase with yeast Ehrlich pathway. Biotechnol Bioeng 102(5):1323-9	SGD
glucose 1-dehydrogenase (NADP+) activity	IDA: Inferred from Direct Assay Assigned on 2008-08-01	Petrash JM, et al.  (2001) Functional genomic studies of aldo-keto reductases. Chem Biol Interact 130-132(1-3):673-83	SGD

Manually curated Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
arabinose catabolic process	IMP: Inferred from Mutant Phenotype Assigned on 2005-01-31 IDA: Inferred from Direct Assay Assigned on 2005-01-31	Traff KL, et al.  (2002) Putative xylose and arabinose reductases in Saccharomyces cerevisiae. Yeast 19(14):1233-41	SGD
cellular response to oxidative stress	IGI: Inferred from Genetic Interaction with SGD:YJR096W, SGD:YDL124W, SGD:GRE3, SGD:GCY1 Assigned on 2008-05-05	Chang Q and Petrash JM  (2008) Disruption of aldo-keto reductase genes leads to elevated markers of oxidative stress and inositol auxotrophy in Saccharomyces cerevisiae. Biochim Biophys Acta 1783(2):237-45	SGD
D-xylose catabolic process	IDA: Inferred from Direct Assay Assigned on 2005-01-31	Traff KL, et al.  (2002) Putative xylose and arabinose reductases in Saccharomyces cerevisiae. Yeast 19(14):1233-41	SGD

* Manually curated GO annotations reflect our best understanding of the basic molecular function, biological process, and cellular component for this gene product. Manually curated annotations are assigned by SGD curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all Manually curated GO annotations for accuracy and completeness. The "Last Reviewed on:" date at the top of this section indicates when these annotations were last reviewed.

Cellular Component

High-throughput Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
cytoplasm	IDA: Inferred from Direct Assay Assigned on 2003-10-28	Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91	SGD
nucleus	IDA: Inferred from Direct Assay Assigned on 2003-10-28	Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91	SGD

** GO annotations from High-throughput experiments are made based on a variety of large scale high-throughput experiments, including genome-wide experiments. Many of these annotations are made based on GO annotations (or mappings to GO annotations) assigned by the authors, rather than SGD curators. While SGD curators read these publications and often work closely with authors to incorporate the information, each individual annotation may not necessarily be reviewed by a curator. GO Annotations from high-throughput experiments will be assigned only when this type of data is available, and thus may not be assigned in all three aspects of the Gene Ontologies.

Molecular Function | Biological Process | Cellular Component

Computational Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
oxidoreductase activity	IEA: Inferred from Electronic Annotation with EBI:IPR018170, EBI:IPR020471 Last updated 2013-03-02	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0560 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB

Computational Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
oxidation-reduction process	IEA: Inferred from Electronic Annotation with EBI:IPR018170, EBI:IPR020471 Last updated 2013-03-02	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0560 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB

Computational Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
cytoplasm	IEA: Inferred from Electronic Annotation with EBI:SL-0086 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:KW-0963 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB

*** Computational GO Annotations are predictions. These annotations are NOT reviewed by a curator. Currently, all computational GO annotations for S. cerevisiae are assigned by an external source (for example, the Gene Ontology Annotation (GOA) project of the European Bioinformatics Institute (EBI)).