This page displays GO annotations in different sections according to the annotation method used to add that annotation to SGD.

Last Reviewed on: 2008-06-10    Molecular Function | Biological Process | Cellular Component

Manually curated Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
catalase activity	IDA: Inferred from Direct Assay Assigned on 2008-06-10	Mate MJ, et al.  (1999) Structure of catalase-A from Saccharomyces cerevisiae. J Mol Biol 286(1):135-49	SGD
	IGI: Inferred from Genetic Interaction with SGD:CTT1 Assigned on 2008-06-10 IMP: Inferred from Mutant Phenotype Assigned on 2008-06-10	Cohen G, et al.  (1985) Isolation of the catalase A gene of Saccharomyces cerevisiae by complementation of the cta1 mutation. Mol Gen Genet 200(1):74-9	SGD

Manually curated Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
age-dependent response to reactive oxygen species	IGI: Inferred from Genetic Interaction with SGD:CTT1 Assigned on 2008-06-10 IMP: Inferred from Mutant Phenotype Assigned on 2008-06-10	Nestelbacher R, et al.  (2000) The influence of oxygen toxicity on yeast mother cell-specific aging. Exp Gerontol 35(1):63-70	SGD
hydrogen peroxide catabolic process	IDA: Inferred from Direct Assay Assigned on 2008-06-10	Mate MJ, et al.  (1999) Structure of catalase-A from Saccharomyces cerevisiae. J Mol Biol 286(1):135-49	SGD
	IGI: Inferred from Genetic Interaction with SGD:CTT1 Assigned on 2008-06-10 IMP: Inferred from Mutant Phenotype Assigned on 2008-06-10	Cohen G, et al.  (1985) Isolation of the catalase A gene of Saccharomyces cerevisiae by complementation of the cta1 mutation. Mol Gen Genet 200(1):74-9	SGD
response to reactive oxygen species	IMP: Inferred from Mutant Phenotype Assigned on 2006-12-08	Lushchak VI and Gospodaryov DV  (2005) Catalases protect cellular proteins from oxidative modification in Saccharomyces cerevisiae. Cell Biol Int 29(3):187-92	SGD

Manually curated Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
mitochondrial matrix	IDA: Inferred from Direct Assay Assigned on 2008-06-10	Petrova VY, et al.  (2004) Dual targeting of yeast catalase A to peroxisomes and mitochondria. Biochem J 380(Pt 2):393-400	SGD
peroxisomal matrix	IDA: Inferred from Direct Assay Assigned on 2008-06-10	Thieringer R, et al.  (1991) Peroxisomes in Saccharomyces cerevisiae: immunofluorescence analysis and import of catalase A into isolated peroxisomes. Mol Cell Biol 11(1):510-22	SGD

* Manually curated GO annotations reflect our best understanding of the basic molecular function, biological process, and cellular component for this gene product. Manually curated annotations are assigned by SGD curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all Manually curated GO annotations for accuracy and completeness. The "Last Reviewed on:" date at the top of this section indicates when these annotations were last reviewed.

There are no High-throughput annotations for CTA1

** GO annotations from High-throughput experiments are made based on a variety of large scale high-throughput experiments, including genome-wide experiments. Many of these annotations are made based on GO annotations (or mappings to GO annotations) assigned by the authors, rather than SGD curators. While SGD curators read these publications and often work closely with authors to incorporate the information, each individual annotation may not necessarily be reviewed by a curator. GO Annotations from high-throughput experiments will be assigned only when this type of data is available, and thus may not be assigned in all three aspects of the Gene Ontologies.

Molecular Function | Biological Process | Cellular Component

Computational Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
catalase activity	IEA: Inferred from Electronic Annotation with EBI:IPR018028, EBI:IPR024708, EBI:IPR011614, EBI:IPR024711 Last updated 2013-03-02	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with IUBMB:1.11.1.6 Last updated 2013-03-02	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB
heme binding	IEA: Inferred from Electronic Annotation with EBI:IPR020835, EBI:IPR018028, EBI:IPR002226, EBI:IPR011614, EBI:IPR024711 Last updated 2013-03-02	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
metal ion binding	IEA: Inferred from Electronic Annotation with EBI:KW-0479 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
oxidoreductase activity	IEA: Inferred from Electronic Annotation with EBI:KW-0560 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
peroxidase activity	IEA: Inferred from Electronic Annotation with EBI:KW-0575 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB

Computational Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
hydrogen peroxide catabolic process	IEA: Inferred from Electronic Annotation with EBI:KW-0376 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
oxidation-reduction process	IEA: Inferred from Electronic Annotation with EBI:IPR020835, EBI:IPR018028, EBI:IPR011614, EBI:IPR024711 Last updated 2013-03-02	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0560 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
response to oxidative stress	IEA: Inferred from Electronic Annotation with EBI:IPR018028, EBI:IPR024711 Last updated 2013-03-02	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro

Computational Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
peroxisome	IEA: Inferred from Electronic Annotation with EBI:SL-0204 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:KW-0576 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB

*** Computational GO Annotations are predictions. These annotations are NOT reviewed by a curator. Currently, all computational GO annotations for S. cerevisiae are assigned by an external source (for example, the Gene Ontology Annotation (GOA) project of the European Bioinformatics Institute (EBI)).