This page displays GO annotations in different sections according to the annotation method used to add that annotation to SGD.

Last Reviewed on: 2007-10-29    Molecular Function | Biological Process | Cellular Component

Manually curated Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
single-stranded telomeric DNA binding	IDA: Inferred from Direct Assay Assigned on 2007-10-29	Gao H, et al.  (2007) RPA-like proteins mediate yeast telomere function. Nat Struct Mol Biol 14(3):208-14	SGD

Manually curated Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
negative regulation of telomere maintenance via telomerase	IGI: Inferred from Genetic Interaction with SGD:EST2, SGD:RAD52 Assigned on 2007-11-02 IMP: Inferred from Mutant Phenotype Assigned on 2007-11-02	Petreaca RC, et al.  (2007) The Role of Stn1p in Saccharomyces cerevisiae Telomere Capping Can Be Separated From Its Interaction With Cdc13p. Genetics 177(3):1459-74	SGD
telomere capping	IGI: Inferred from Genetic Interaction with SGD:POL12 Assigned on 2007-10-30 IMP: Inferred from Mutant Phenotype Assigned on 2007-10-30 IPI: Inferred from Physical Interaction with SGD:POL12 Assigned on 2007-10-30	Grossi S, et al.  (2004) Pol12, the B subunit of DNA polymerase alpha, functions in both telomere capping and length regulation. Genes Dev 18(9):992-1006	SGD
	IGI: Inferred from Genetic Interaction with SGD:CDC13 Assigned on 2007-10-30 IMP: Inferred from Mutant Phenotype Assigned on 2007-10-30 IPI: Inferred from Physical Interaction with SGD:CDC13 Assigned on 2007-10-30	Grandin N, et al.  (1997) Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13. Genes Dev 11(4):512-27	SGD

Manually curated Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
nuclear telomere cap complex	IPI: Inferred from Physical Interaction with SGD:CDC13 Assigned on 2007-10-30	Grandin N, et al.  (1997) Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13. Genes Dev 11(4):512-27	SGD
	IPI: Inferred from Physical Interaction with SGD:TEN1 Assigned on 2007-10-30	Grandin N, et al.  (2001) Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13. EMBO J 20(5):1173-83	SGD

* Manually curated GO annotations reflect our best understanding of the basic molecular function, biological process, and cellular component for this gene product. Manually curated annotations are assigned by SGD curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all Manually curated GO annotations for accuracy and completeness. The "Last Reviewed on:" date at the top of this section indicates when these annotations were last reviewed.

There are no High-throughput annotations for STN1

** GO annotations from High-throughput experiments are made based on a variety of large scale high-throughput experiments, including genome-wide experiments. Many of these annotations are made based on GO annotations (or mappings to GO annotations) assigned by the authors, rather than SGD curators. While SGD curators read these publications and often work closely with authors to incorporate the information, each individual annotation may not necessarily be reviewed by a curator. GO Annotations from high-throughput experiments will be assigned only when this type of data is available, and thus may not be assigned in all three aspects of the Gene Ontologies.

Cellular Component

Computational Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
chromosome	IEA: Inferred from Electronic Annotation with EBI:KW-0158 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
chromosome, telomeric region	IEA: Inferred from Electronic Annotation with EBI:SL-0276 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:KW-0779 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB

*** Computational GO Annotations are predictions. These annotations are NOT reviewed by a curator. Currently, all computational GO annotations for S. cerevisiae are assigned by an external source (for example, the Gene Ontology Annotation (GOA) project of the European Bioinformatics Institute (EBI)).