This page displays GO annotations in different sections according to the annotation method used to add that annotation to SGD.

Last Reviewed on: 2007-04-03    Molecular Function | Biological Process | Cellular Component

Manually curated Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
chaperone binding	IMP: Inferred from Mutant Phenotype Assigned on 2004-07-23 IPI: Inferred from Physical Interaction Assigned on 2004-07-23	Fang Y, et al.  (1998) SBA1 encodes a yeast hsp90 cochaperone that is homologous to vertebrate p23 proteins. Mol Cell Biol 18(7):3727-34	SGD

Manually curated Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
positive regulation of telomere maintenance via telomerase	IMP: Inferred from Mutant Phenotype Assigned on 2007-04-03 IDA: Inferred from Direct Assay Assigned on 2007-04-03	Toogun OA, et al.  (2007) The p23 molecular chaperone promotes functional telomerase complexes through DNA dissociation. Proc Natl Acad Sci U S A 104(14):5765-70	SGD
protein folding	IMP: Inferred from Mutant Phenotype Assigned on 2002-11-18 IPI: Inferred from Physical Interaction Assigned on 2002-11-18	Fang Y, et al.  (1998) SBA1 encodes a yeast hsp90 cochaperone that is homologous to vertebrate p23 proteins. Mol Cell Biol 18(7):3727-34	SGD
regulation of telomerase activity	IMP: Inferred from Mutant Phenotype Assigned on 2007-04-03 IDA: Inferred from Direct Assay Assigned on 2007-04-03	Toogun OA, et al.  (2007) The p23 molecular chaperone promotes functional telomerase complexes through DNA dissociation. Proc Natl Acad Sci U S A 104(14):5765-70	SGD

Manually curated Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
cytoplasm	IDA: Inferred from Direct Assay Assigned on 2002-08-22	Knoblauch R and Garabedian MJ  (1999) Role for Hsp90-associated cochaperone p23 in estrogen receptor signal transduction. Mol Cell Biol 19(5):3748-59	SGD
nucleus	IDA: Inferred from Direct Assay Assigned on 2002-08-22	Knoblauch R and Garabedian MJ  (1999) Role for Hsp90-associated cochaperone p23 in estrogen receptor signal transduction. Mol Cell Biol 19(5):3748-59	SGD

* Manually curated GO annotations reflect our best understanding of the basic molecular function, biological process, and cellular component for this gene product. Manually curated annotations are assigned by SGD curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all Manually curated GO annotations for accuracy and completeness. The "Last Reviewed on:" date at the top of this section indicates when these annotations were last reviewed.

There are no High-throughput annotations for SBA1

** GO annotations from High-throughput experiments are made based on a variety of large scale high-throughput experiments, including genome-wide experiments. Many of these annotations are made based on GO annotations (or mappings to GO annotations) assigned by the authors, rather than SGD curators. While SGD curators read these publications and often work closely with authors to incorporate the information, each individual annotation may not necessarily be reviewed by a curator. GO Annotations from high-throughput experiments will be assigned only when this type of data is available, and thus may not be assigned in all three aspects of the Gene Ontologies.

There are no Computational annotations for SBA1

*** Computational GO Annotations are predictions. These annotations are NOT reviewed by a curator. Currently, all computational GO annotations for S. cerevisiae are assigned by an external source (for example, the Gene Ontology Annotation (GOA) project of the European Bioinformatics Institute (EBI)).