This page displays GO annotations in different sections according to the annotation method used to add that annotation to SGD.

Last Reviewed on: 2004-06-10    Molecular Function | Biological Process | Cellular Component

Manually curated Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
molecular_function unknown	ND: No Biological Data Available Assigned on 2002-08-11	SGD  (2002) Use of the ND evidence code for Gene Ontology (GO) terms in SGD ()	SGD

Manually curated Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
maintenance of DNA trinucleotide repeats	IMP: Inferred from Mutant Phenotype Assigned on 2011-04-01	Gellon L, et al.  (2011) New Functions of Ctf18-RFC in Preserving Genome Stability outside Its Role in Sister Chromatid Cohesion. PLoS Genet 7(2):e1001298	SGD
mitotic sister chromatid cohesion	IMP: Inferred from Mutant Phenotype Assigned on 2004-06-10	Mayer ML, et al.  (2001) Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae. Mol Cell 7(5):959-70	SGD
	IGI: Inferred from Genetic Interaction with SGD:CSM3 Assigned on 2008-09-18	Xu H, et al.  (2007) Genetic dissection of parallel sister-chromatid cohesion pathways. Genetics 176(3):1417-29	SGD

Manually curated Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
Ctf18 RFC-like complex	IPI: Inferred from Physical Interaction with SGD:CTF8 Assigned on 2007-07-26	Mayer ML, et al.  (2001) Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae. Mol Cell 7(5):959-70	SGD

* Manually curated GO annotations reflect our best understanding of the basic molecular function, biological process, and cellular component for this gene product. Manually curated annotations are assigned by SGD curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all Manually curated GO annotations for accuracy and completeness. The "Last Reviewed on:" date at the top of this section indicates when these annotations were last reviewed.

Biological Process

High-throughput Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
response to DNA damage stimulus	IMP: Inferred from Mutant Phenotype Assigned on 2006-04-06	Chang M, et al.  (2002) A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage. Proc Natl Acad Sci U S A 99(26):16934-9	SGD

** GO annotations from High-throughput experiments are made based on a variety of large scale high-throughput experiments, including genome-wide experiments. Many of these annotations are made based on GO annotations (or mappings to GO annotations) assigned by the authors, rather than SGD curators. While SGD curators read these publications and often work closely with authors to incorporate the information, each individual annotation may not necessarily be reviewed by a curator. GO Annotations from high-throughput experiments will be assigned only when this type of data is available, and thus may not be assigned in all three aspects of the Gene Ontologies.

Biological Process

Computational Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
DNA replication	IEA: Inferred from Electronic Annotation with EBI:KW-0235 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB

*** Computational GO Annotations are predictions. These annotations are NOT reviewed by a curator. Currently, all computational GO annotations for S. cerevisiae are assigned by an external source (for example, the Gene Ontology Annotation (GOA) project of the European Bioinformatics Institute (EBI)).