This page displays GO annotations in different sections according to the annotation method used to add that annotation to SGD.

Last Reviewed on: 2007-05-04    Molecular Function | Biological Process | Cellular Component

Manually curated Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
molecular_function unknown	ND: No Biological Data Available Assigned on 2006-12-21	SGD  (2002) Use of the ND evidence code for Gene Ontology (GO) terms in SGD ()	SGD

Manually curated Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
proteasome assembly	IMP: Inferred from Mutant Phenotype Assigned on 2004-11-15	Ramos PC, et al.  (1998) Ump1p is required for proper maturation of the 20S proteasome and becomes its substrate upon completion of the assembly. Cell 92(4):489-99	SGD
	IGI: Inferred from Genetic Interaction with SGD:PRE7 Assigned on 2007-05-04	Li X, et al.  (2007) beta-Subunit appendages promote 20S proteasome assembly by overcoming an Ump1-dependent checkpoint. EMBO J 26(9):2339-49	SGD
response to DNA damage stimulus	IDA: Inferred from Direct Assay Assigned on 2004-11-16	Mieczkowski P, et al.  (2000) Expression of UMP1 is inducible by DNA damage and required for resistance of S. cerevisiae cells to UV light. Curr Genet 38(2):53-9	SGD
ubiquitin-dependent protein catabolic process	IMP: Inferred from Mutant Phenotype Assigned on 2004-11-16	Ramos PC, et al.  (1998) Ump1p is required for proper maturation of the 20S proteasome and becomes its substrate upon completion of the assembly. Cell 92(4):489-99	SGD

Manually curated Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
cytoplasm	IDA: Inferred from Direct Assay Assigned on 2004-11-15	Lehmann A, et al.  (2002) 20 S proteasomes are imported as precursor complexes into the nucleus of yeast. J Mol Biol 317(3):401-13	SGD
nucleus	IDA: Inferred from Direct Assay Assigned on 2004-11-15	Lehmann A, et al.  (2002) 20 S proteasomes are imported as precursor complexes into the nucleus of yeast. J Mol Biol 317(3):401-13	SGD

* Manually curated GO annotations reflect our best understanding of the basic molecular function, biological process, and cellular component for this gene product. Manually curated annotations are assigned by SGD curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all Manually curated GO annotations for accuracy and completeness. The "Last Reviewed on:" date at the top of this section indicates when these annotations were last reviewed.

There are no High-throughput annotations for UMP1

** GO annotations from High-throughput experiments are made based on a variety of large scale high-throughput experiments, including genome-wide experiments. Many of these annotations are made based on GO annotations (or mappings to GO annotations) assigned by the authors, rather than SGD curators. While SGD curators read these publications and often work closely with authors to incorporate the information, each individual annotation may not necessarily be reviewed by a curator. GO Annotations from high-throughput experiments will be assigned only when this type of data is available, and thus may not be assigned in all three aspects of the Gene Ontologies.

Cellular Component

Computational Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
proteasome complex	IEA: Inferred from Electronic Annotation with EBI:KW-0647 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB

*** Computational GO Annotations are predictions. These annotations are NOT reviewed by a curator. Currently, all computational GO annotations for S. cerevisiae are assigned by an external source (for example, the Gene Ontology Annotation (GOA) project of the European Bioinformatics Institute (EBI)).