This page displays GO annotations in different sections according to the annotation method used to add that annotation to SGD.

Last Reviewed on: 2005-11-11    Molecular Function | Biological Process | Cellular Component

Manually curated Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
nucleoside-triphosphatase activity	IGI: Inferred from Genetic Interaction with SGD:NPP2, SGD:NPP1 Assigned on 2005-11-11 IMP: Inferred from Mutant Phenotype Assigned on 2005-11-11	Kennedy EJ, et al.  (2005) Pho5p and newly identified nucleotide pyrophosphatases/ phosphodiesterases regulate extracellular nucleotide phosphate metabolism in Saccharomyces cerevisiae. Eukaryot Cell 4(11):1892-901	SGD
nucleoside-triphosphate diphosphatase activity	IGI: Inferred from Genetic Interaction with SGD:NPP2, SGD:NPP1 Assigned on 2005-11-11 IMP: Inferred from Mutant Phenotype Assigned on 2005-11-11	Kennedy EJ, et al.  (2005) Pho5p and newly identified nucleotide pyrophosphatases/ phosphodiesterases regulate extracellular nucleotide phosphate metabolism in Saccharomyces cerevisiae. Eukaryot Cell 4(11):1892-901	SGD

Manually curated Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
cellular response to phosphate starvation	IEP: Inferred from Expression Pattern Assigned on 2005-11-11 IMP: Inferred from Mutant Phenotype Assigned on 2005-11-11	Kennedy EJ, et al.  (2005) Pho5p and newly identified nucleotide pyrophosphatases/ phosphodiesterases regulate extracellular nucleotide phosphate metabolism in Saccharomyces cerevisiae. Eukaryot Cell 4(11):1892-901	SGD
phosphate-containing compound metabolic process	IMP: Inferred from Mutant Phenotype Assigned on 2005-11-11	Kennedy EJ, et al.  (2005) Pho5p and newly identified nucleotide pyrophosphatases/ phosphodiesterases regulate extracellular nucleotide phosphate metabolism in Saccharomyces cerevisiae. Eukaryot Cell 4(11):1892-901	SGD

Manually curated Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
fungal-type cell wall	IDA: Inferred from Direct Assay Assigned on 2001-09-26	Haguenauer-Tsapis R, et al.  (1986) A deletion that includes the segment coding for the signal peptidase cleavage site delays release of Saccharomyces cerevisiae acid phosphatase from the endoplasmic reticulum. Mol Cell Biol 6(2):723-9	SGD

* Manually curated GO annotations reflect our best understanding of the basic molecular function, biological process, and cellular component for this gene product. Manually curated annotations are assigned by SGD curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all Manually curated GO annotations for accuracy and completeness. The "Last Reviewed on:" date at the top of this section indicates when these annotations were last reviewed.

Biological Process

High-throughput Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
regulation of cell size	IMP: Inferred from Mutant Phenotype Assigned on 2006-07-14	Jorgensen P, et al.  (2002) Systematic identification of pathways that couple cell growth and division in yeast. Science 297(5580):395-400	SGD

** GO annotations from High-throughput experiments are made based on a variety of large scale high-throughput experiments, including genome-wide experiments. Many of these annotations are made based on GO annotations (or mappings to GO annotations) assigned by the authors, rather than SGD curators. While SGD curators read these publications and often work closely with authors to incorporate the information, each individual annotation may not necessarily be reviewed by a curator. GO Annotations from high-throughput experiments will be assigned only when this type of data is available, and thus may not be assigned in all three aspects of the Gene Ontologies.

Molecular Function | Biological Process | Cellular Component

Computational Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
acid phosphatase activity	IEA: Inferred from Electronic Annotation with EBI:IPR000560 Last updated 2013-03-02	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with IUBMB:3.1.3.2 Last updated 2013-03-02	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB
hydrolase activity	IEA: Inferred from Electronic Annotation with EBI:KW-0378 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
phosphatase activity	IEA: Inferred from Electronic Annotation with EBI:IPR016274 Last updated 2013-03-02	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro

Computational Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
dephosphorylation	IEA: Inferred from Electronic Annotation with EBI:IPR016274 Last updated 2013-03-02	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	GOC

Computational Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
extracellular region	IEA: Inferred from Electronic Annotation with EBI:SL-0243 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries.	UniProtKB
	IEA: Inferred from Electronic Annotation with EBI:KW-0964 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB

*** Computational GO Annotations are predictions. These annotations are NOT reviewed by a curator. Currently, all computational GO annotations for S. cerevisiae are assigned by an external source (for example, the Gene Ontology Annotation (GOA) project of the European Bioinformatics Institute (EBI)).