This page displays GO annotations in different sections according to the annotation method used to add that annotation to SGD.

Last Reviewed on: 2007-03-13    Molecular Function | Biological Process

Manually curated Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
succinate-semialdehyde dehydrogenase [NAD(P)+] activity	ISS: Inferred from Sequence or structural Similarity with EBI:P25526 Assigned on 2007-03-12 IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	Coleman ST, et al.  (2001) Expression of a glutamate decarboxylase homologue is required for normal oxidative stress tolerance in Saccharomyces cerevisiae. J Biol Chem 276(1):244-50	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2007-11-06	Ramos F, et al.  (1985) Mutations affecting the enzymes involved in the utilization of 4-aminobutyric acid as nitrogen source by the yeast Saccharomyces cerevisiae. Eur J Biochem 149(2):401-4	SGD

Manually curated Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
cellular response to oxidative stress	IMP: Inferred from Mutant Phenotype Assigned on 2001-01-18	Coleman ST, et al.  (2001) Expression of a glutamate decarboxylase homologue is required for normal oxidative stress tolerance in Saccharomyces cerevisiae. J Biol Chem 276(1):244-50	SGD
gamma-aminobutyric acid catabolic process	IEP: Inferred from Expression Pattern Assigned on 2007-03-13 ISS: Inferred from Sequence or structural Similarity with EBI:P25526 Assigned on 2007-03-13 IMP: Inferred from Mutant Phenotype Assigned on 2007-03-13	Coleman ST, et al.  (2001) Expression of a glutamate decarboxylase homologue is required for normal oxidative stress tolerance in Saccharomyces cerevisiae. J Biol Chem 276(1):244-50	SGD
	IMP: Inferred from Mutant Phenotype Assigned on 2007-11-06	Ramos F, et al.  (1985) Mutations affecting the enzymes involved in the utilization of 4-aminobutyric acid as nitrogen source by the yeast Saccharomyces cerevisiae. Eur J Biochem 149(2):401-4	SGD
glutamate decarboxylation to succinate	IGI: Inferred from Genetic Interaction with SGD:GAD1 Assigned on 2007-03-13 ISS: Inferred from Sequence or structural Similarity with EBI:P25526 Assigned on 2007-03-13 IMP: Inferred from Mutant Phenotype Assigned on 2007-03-13	Coleman ST, et al.  (2001) Expression of a glutamate decarboxylase homologue is required for normal oxidative stress tolerance in Saccharomyces cerevisiae. J Biol Chem 276(1):244-50	SGD

* Manually curated GO annotations reflect our best understanding of the basic molecular function, biological process, and cellular component for this gene product. Manually curated annotations are assigned by SGD curators based on published papers when available, or by curatorial statements if necessary. Curators periodically review all Manually curated GO annotations for accuracy and completeness. The "Last Reviewed on:" date at the top of this section indicates when these annotations were last reviewed.

Cellular Component

High-throughput Cellular Component
Annotation(s)	Evidence	Reference(s)	Assigned By
cytoplasm	IDA: Inferred from Direct Assay Assigned on 2003-10-28	Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91	SGD

** GO annotations from High-throughput experiments are made based on a variety of large scale high-throughput experiments, including genome-wide experiments. Many of these annotations are made based on GO annotations (or mappings to GO annotations) assigned by the authors, rather than SGD curators. While SGD curators read these publications and often work closely with authors to incorporate the information, each individual annotation may not necessarily be reviewed by a curator. GO Annotations from high-throughput experiments will be assigned only when this type of data is available, and thus may not be assigned in all three aspects of the Gene Ontologies.

Molecular Function | Biological Process

Computational Molecular Function
Annotation(s)	Evidence	Reference(s)	Assigned By
oxidoreductase activity	IEA: Inferred from Electronic Annotation with EBI:IPR016161, EBI:IPR015590, EBI:IPR016162, EBI:IPR016160, EBI:IPR016163 Last updated 2013-03-02	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0560 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA: Inferred from Electronic Annotation with EBI:IPR016163 Last updated 2013-03-02	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
succinate-semialdehyde dehydrogenase [NAD(P)+] activity	IEA: Inferred from Electronic Annotation with EBI:IPR010102 Last updated 2013-03-02	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with IUBMB:1.2.1.16 Last updated 2013-03-02	GOA curators and MGI curators  (2001) Gene Ontology annotation based on Enzyme Commission mapping.	UniProtKB

Computational Biological Process
Annotation(s)	Evidence	Reference(s)	Assigned By
gamma-aminobutyric acid catabolic process	IEA: Inferred from Electronic Annotation with EBI:IPR010102 Last updated 2013-03-02	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with UniPathway:UPA00733 Last updated 2013-03-02	UniProt-GOA  (2012) Gene Ontology annotation based on UniPathway vocabulary mapping.	UniPathway
metabolic process	IEA: Inferred from Electronic Annotation with EBI:IPR016161, EBI:IPR015590, EBI:IPR016162, EBI:IPR016160, EBI:IPR016163 Last updated 2013-03-02	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
oxidation-reduction process	IEA: Inferred from Electronic Annotation with EBI:IPR016161, EBI:IPR015590, EBI:IPR016162, EBI:IPR016160, EBI:IPR010102, EBI:IPR016163 Last updated 2013-03-02	DDB, et al.  (2001) Gene Ontology annotation through association of InterPro records with GO terms.	InterPro
	IEA: Inferred from Electronic Annotation with EBI:KW-0560 Last updated 2013-03-02	UniProt-GOA  (2011) Gene Ontology annotation based on manual assignment of UniProtKB keywords in UniProtKB/Swiss-Prot entries.	UniProtKB

*** Computational GO Annotations are predictions. These annotations are NOT reviewed by a curator. Currently, all computational GO annotations for S. cerevisiae are assigned by an external source (for example, the Gene Ontology Annotation (GOA) project of the European Bioinformatics Institute (EBI)).